YRC Public Data Repository - Protein Structure Prediction

Protein:	ZTA1
Organism:	Saccharomyces cerevisiae
Length:	334 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ZTA1.

Description	E-value	Query Range	Subject Range
QOR_YEAST - Probable quinone oxidoreductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ZTA1 PE=... ZTA1 - NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has si...	6.0E-92	[1..334]	[1..334]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-90	[8..330]	[1..322]
gi\|15234529, gi\|... - pir\|\|T05166 quinone reductase homolog F18E5.200 - Arabidopsis thaliana, gi\|7268955\|emb\|CAB81265.1\| p...	3.0E-89	[9..331]	[1..324]
gi\|15155807, gi\|... - gi\|15888165\|ref\|NP_353846.1\| hypothetical protein AGR_C_1508 [Agrobacterium tumefaciens str. C58], g... gi\|25282962 - pir\|\|F97459 probable quinone oxidoreductase [imported] - Agrobacterium tumefaciens (strain C58, Cere...	5.0E-89	[2..333]	[15..348]
gi\|2983768, gi\|1... - gi\|2983768\|gb\|AAC07327.1\| alcohol dehydrogenase [Aquifex aeolicus VF5], gi\|15606558\|ref\|NP_213938.1\|... gi\|7427649 - pir\|\|C70418 probable alcohol dehydrogenase (EC 1.1.1.-) - Aquifex aeolicus	6.0E-87	[9..332]	[1..342]
gi\|17429203 - gi\|17429203\|emb\|CAD15891.1\| probable nadph:quinone reductase, zeta-crystallin homolog oxidoreductase... gi\|17546903 - gi\|17546903\|ref\|NP_520305.1\| NADPH:quinone reductase, zeta-crystallin homolog oxidoreductase protein...	7.0E-87	[8..330]	[1..322]
gi\|13699908 - gi\|13699908\|dbj\|BAB41213.1\| zeta-crystallin [Hyla japonica]	2.0E-86	[2..332]	[1..329]
gi\|17982195, gi\|... - gi\|17986585\|ref\|NP_539219.1\| quinone oxidoreductase [Brucella melitensis 16M], gi\|17982195\|gb\|AAL514... gi\|25283017 - pir\|\|AH3289 NADPH2:quinone reductase (EC 1.6.5.5) [imported] - Brucella melitensis (strain 16M)	2.0E-86	[1..333]	[3..336]
gi\|4378174 - gi\|4378174\|gb\|AAD19419.1\| unknown [Zymomonas mobilis] gi\|56552668, gi\|... - gi\|56552668\|ref\|YP_163507.1\| NADPH:quinone oxidoreductase [Zymomonas mobilis subsp. mobilis ZM4], gi...	2.0E-86	[8..334]	[1..328]
gi\|13470724, gi\|... - gi\|14021467\|dbj\|BAB48079.1\| quinone oxidoreductase [Mesorhizobium loti MAFF303099], gi\|13470724\|ref\|...	6.0E-86	[8..330]	[1..323]

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Predicted Domain #1

Region A:
Residues: [1-130]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKCTIPEQQK VILIDEIGGY DVIKYEDYPV PSISEEELLI KNKYTGVNYI ESYFRKGIYP  60
   61 CEKPYVLGRE ASGTVVAKGK GVTNFEVGDQ VAYISNSTFA QYSKISSQGP VMKLPKGTSD 120
  121 EELKLYAAGL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [302-334]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIYKTYPLRD YRTAAADIES RKTVGKLVLE IPQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	530.156545
Match:	1qorA_
Description:	Quinone oxidoreductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ethanol binding	3.52197234018599	bayes_pls_golite062009
NAD or NADH binding	3.39892156245282	bayes_pls_golite062009
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
methylglyoxal reductase (NADH-dependent) activity	3.00190838171391	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	2.94416173750168	bayes_pls_golite062009
retinol binding	2.90377414635828	bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent	2.26153457113968	bayes_pls_golite062009
NADPH:quinone reductase activity	2.16668841986245	bayes_pls_golite062009
alcohol binding	2.01620480773869	bayes_pls_golite062009
all-trans retinal binding	1.96535395605564	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	1.81250968237368	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
DNA binding	1.61355789916908	bayes_pls_golite062009
transcription regulator activity	1.55390653047158	bayes_pls_golite062009
nucleic acid binding	1.48478425318425	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
chaperone binding	1.19079350615542	bayes_pls_golite062009
retinol dehydrogenase activity	1.16811519855038	bayes_pls_golite062009
binding	0.982999356179965	bayes_pls_golite062009
transcription factor activity	0.91090893050278	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.905392379451071	bayes_pls_golite062009
RNA binding	0.843556706364142	bayes_pls_golite062009
structural molecule activity	0.75267483298133	bayes_pls_golite062009
protein binding	0.507836099271263	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	0.44080203587472	bayes_pls_golite062009
molecular transducer activity	0.435382281024944	bayes_pls_golite062009
signal transducer activity	0.435382281024944	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.331998750763528	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.261132005311306	bayes_pls_golite062009
receptor activity	0.219998435023684	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.216422278300306	bayes_pls_golite062009
cation transmembrane transporter activity	0.200409117794759	bayes_pls_golite062009
passive transmembrane transporter activity	0.166857973838454	bayes_pls_golite062009
channel activity	0.166857973838454	bayes_pls_golite062009
substrate-specific channel activity	0.14195924411997	bayes_pls_golite062009
G-protein coupled receptor activity	0.135469305070471	bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity	0.124826575912808	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	0.118312276550651	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.0992243118937675	bayes_pls_golite062009
ion channel activity	0.0487923057681532	bayes_pls_golite062009
ion transmembrane transporter activity	0.0361234153211201	bayes_pls_golite062009
transmembrane receptor activity	0.0180992866169776	bayes_pls_golite062009
gated channel activity	0.015794644474568	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [131-301]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQVLTALSFT NEAYHVKKGD YVLLFAAAGG VGLILNQLLK MKGAHTIAVA STDEKLKIAK  60
   61 EYGAEYLINA SKEDILRQVL KFTNGKGVDA SFDSVGKDTF EISLAALKRK GVFVSFGNAS 120
  121 GLIPPFSITR LSPKNITLVR PQLYGYIADP EEWKYYSDEF FGLVNSKKLN I

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	530.156545
Match:	1qorA_
Description:	Quinone oxidoreductase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: