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View Structure Prediction Details

Protein: EDS1
Organism: Saccharomyces cerevisiae
Length: 919 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EDS1.

Description E-value Query
Range
Subject
Range
EDS1 - Putative zinc cluster protein; YBR033W is not an essential gene
EDS1_YEAST - Transcriptional regulatory protein EDS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
0.0 [1..919] [1..919]
YCN3_SCHPO - Uncharacterized transcriptional regulatory protein C320.03 OS=Schizosaccharomyces pombe (strain 972 ...
SPCC320.03 - transcription factor
3.0E-45 [35..390] [56..488]
XLNR_ASPFN - Xylanolytic transcriptional activator xlnR OS=Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / ...
XLNR_ASPOR - Xylanolytic transcriptional activator xlnR OS=Aspergillus oryzae GN=xlnR PE=1 SV=2
XLNR_ASPOR - Xylanolytic transcriptional activator xlnR OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) GN=xln...
3.0E-44 [3..335] [61..428]
TCNA_TRYCR - Sialidase OS=Trypanosoma cruzi GN=TCNA PE=2 SV=1
6.0E-44 [5..350] [723..1075]
SLP1_CLOTM, SLAP... - (Q06852) Cell surface glycoprotein 1 precursor (Outer layer protein B) (S-layer protein 1), Cell sur...
9.0E-39 [5..400] [930..1308]
XLNR_ASPNG - Transcriptional activator xlnR OS=Aspergillus niger GN=xlnR PE=4 SV=1
1.0E-37 [1..321] [1..312]
gi|14669834 - gi|14669834|dbj|BAB62022.1| xylanolytic transcriptional activator [Aspergillus kawachii]
4.0E-36 [14..321] [7..312]

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Predicted Domain #1
Region A:
Residues: [1-134]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHHVPNLYG TPIRDPHERK RNSASMGEVN QSVSSRNCER GSEKGTKQRK KASHACDQCR  60
   61 RKRIKCRFDK HTGVCQGCLE VGEKCQFIRV PLKRGPAKKR GSVVSIEKFS SDNDPLQYRP 120
  121 RTHSYPMNSG NNYL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.69897
Match: 1hwtC_
Description: Hap1 (Cyp1); HAP1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.625108569999163 bayes_pls_golite062009
nucleic acid binding 0.297563906361978 bayes_pls_golite062009
DNA binding 0.187456195219132 bayes_pls_golite062009
transcription regulator activity 0.0382143741325586 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [135-221]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSLARNSSFP SISSLFVPSI TAQSQQFVKV PYDDIKRRSS LAILGSDSSI STEFGGNYRL  60
   61 DENLNVRQEG KDIVAKGMIT PVEEMGA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [222-393]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSSNVRRQGS QSLPIQEQRA SPYINPFISG RSRLSSLSYT SEATTSEGNT QGKNQCMLTP  60
   61 NSVRSIEKER LNSLTAGFPN KKLGTDGRSD KWDKNSTWKP VYRSSNPSHP STEKNVSLNQ 120
  121 EASAKPLMLG TYRQFDATSF YKVLGIYYNF FHINFPVIPI NKSKFTDMLD PE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [394-447]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPNVIDEIRQ INNEIIQCFK TALEVLVFCK IKQRRSSKST KSWSRDSLCD FQKG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [448-807]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYYIQNFNKC IADCFQSLIT IKPVLKQNSS VIPSRIKFIY FSTIIVLNFI LILAGEESSL  60
   61 LLGPSVGVFN EFQAHKLFLP FQNTSPMLLL NSNEESGDEI LDYAVLFKRL YILLNILDTL 120
  121 QSFRLGQPKL INLNFGSAIE TYFSDKTGHN QVVEKAPVAL DNILRNLKLG EFITYFVLNR 180
  181 KSLQVNVPHH LLFTNQTDYG EFAVEKGEHD NIAGKFETLL KKKEILIRKL LNIEQKNDHI 240
  241 LENCCNSDAE MKNIGELVCS MITLVSGILD SITNMNAENS VDLDSKPLPN AYFAQDSEEE 300
  301 LMSPTQSITS NLASEENTRC TTKDLMGTVS IFMLPMVEEC YNIISLIGPI PTTLISLYIR 360
  361 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.04
Match: 1b8fA
Description: Histidine ammonia-lyase (HAL)
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [808-919]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGNMAKGIND RIMTLSTALN ELVQITALFN TLEPFRKNAH DRAKRYYVSA TSSTGCYESV  60
   61 MKSMYSGKCA ASNASNVAPS EEENKKILKK FADIGWKLMD DSELGCCCCF FN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle