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View Structure Prediction Details

Protein: ECM21
Organism: Saccharomyces cerevisiae
Length: 1117 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ECM21.

Description E-value Query
Range
Subject
Range
gi|190408919 - gi|190408919|gb|EDV12184.1| extracellular matrix protein 21 [Saccharomyces cerevisiae RM11-1a]
ECM21_YEAST - Protein ECM21 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ECM21 PE=1 SV=2
ECM21 - Protein involved in regulating the endocytosis of plasma membrane proteins; identified as a substrat...
gi|151946300 - gi|151946300|gb|EDN64522.1| conserved protein [Saccharomyces cerevisiae YJM789]
0.0 [41..1117] [1..1077]
ALY1_SCHPO - Putative arrestin-related trafficking adapter C839.02 OS=Schizosaccharomyces pombe (strain 972 / ATC...
SPBC839.02 - arrestin Aly1 related
1.0E-25 [550..639] [231..316]

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Predicted Domain #1
Region A:
Residues: [1-507]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPFITSRPVA KNSSHSLSET DLNQSKGQPF QPSPTKKLGS MQQRRRSSTI RHALSSLLGG  60
   61 ANVHSPAVLN NTTKGGNNNG NIRSSNTDAQ LLGKKQNKQP PPNARRHSTT AIQGSISDSA 120
  121 TTTPRSSTSD TNRRTSGRLS VDQEPRISGG RYSQIEEDST VLDFDDDHNS SAVVSSDLSS 180
  181 TSLTRLANSK KFNEQFLIEY LTARGLLGPK TVLSNEYLKI SISTSGESVF LPTISSNDDE 240
  241 YLSRLNGLND GTDDAEADFF MDGIDQQEGN TPSLATTAAA TESGGSINEN RDTLLRENNS 300
  301 GDHPGSGSEL NTRSVEIDSS MVSYSIAVIV SVKKPTRFTD MQLELCSRVK VFWNTGVPPT 360
  361 KTFNEEFYNA ASMKWNLNDE NFDLFVPLSI SPDDQMIENN SNDRQMRLFK NIPTEERLYL 420
  421 DKTKTKASLL NAIDVNKTHL YQPGDYVFLV PVVFSNHIPE TIYLPSARVS YRLRLATKAI 480
  481 NRKGFYRQDS NSPQPIVSPD SSSSLSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [508-703]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTSSLKLTET ESAQAHRRIS NTLFSKVKNH LHMSSHQLKN EESGEEDIFA EYPIKVIRTP  60
   61 PPVAVSTANK PIYINRVWTD SLSYEISFAQ KYVSLNSEVP IKIKLAPICK NVCVKRIHVS 120
  121 ITERVTFVSK GYEYEYDQTD PVAKDPYNPY YLDFASKRRK ERSVSLFEIR TKEKGTRALR 180
  181 EEIVENSFND NLLSYS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [704-1117]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFDDDSDSKG NPKERLGITE PIIIETKLKF PKYEDLDKRT AKIIPPYGID AYTSIPNPEH  60
   61 AVANGPSHRR PSVIGFLSGH KGSKSHEENE KPVYDPKFHQ TIIKSNSGLP VKTHTRLNTP 120
  121 KRGLYLDSLH FSNVYCRHKL EIMLRISKPD PECPSKLRHY EVLIDTPIFL VSEQCNSGNM 180
  181 ELPTYDMATM EGKGNQVPLS MNSDFFGNTC PPPPTFEEAI SVPASPIVSP MGSPNIMASY 240
  241 DPDLLSIQQL NLSRTTSVSG PSGYSDDAGV PNVNRNSISN ANAMNGSISN SAFVSGNSGQ 300
  301 GVARARATSV NDRSRFNNLD KLLSTPSPVN RSHNSSPTNG LSQANGTVRI PNATTENSKD 360
  361 KQNEFFKKGY TLANVKDDEE QEGIVSSSSA DSLLSHGNEP PRYDEIVPLM SDEE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [387-878]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLSISPDDQM IENNSNDRQM RLFKNIPTEE RLYLDKTKTK ASLLNAIDVN KTHLYQPGDY  60
   61 VFLVPVVFSN HIPETIYLPS ARVSYRLRLA TKAINRKGFY RQDSNSPQPI VSPDSSSSLS 120
  121 STTSSLKLTE TESAQAHRRI SNTLFSKVKN HLHMSSHQLK NEESGEEDIF AEYPIKVIRT 180
  181 PPPVAVSTAN KPIYINRVWT DSLSYEISFA QKYVSLNSEV PIKIKLAPIC KNVCVKRIHV 240
  241 SITERVTFVS KGYEYEYDQT DPVAKDPYNP YYLDFASKRR KERSVSLFEI RTKEKGTRAL 300
  301 REEIVENSFN DNLLSYSPFD DDSDSKGNPK ERLGITEPII IETKLKFPKY EDLDKRTAKI 360
  361 IPPYGIDAYT SIPNPEHAVA NGPSHRRPSV IGFLSGHKGS KSHEENEKPV YDPKFHQTII 420
  421 KSNSGLPVKT HTRLNTPKRG LYLDSLHFSN VYCRHKLEIM LRISKPDPEC PSKLRHYEVL 480
  481 IDTPIFLVSE QC

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.29
Match: 1jsyA
Description: Arrestin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.80286284844302 bayes_pls_golite062009
protein binding 1.608080422834 bayes_pls_golite062009
transporter activity 1.10239137184953 bayes_pls_golite062009
transmembrane transporter activity 0.949536954960448 bayes_pls_golite062009
substrate-specific transporter activity 0.781060752903079 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.660409340901077 bayes_pls_golite062009
ion transmembrane transporter activity 0.56446678342098 bayes_pls_golite062009
cation transmembrane transporter activity 0.486294295028555 bayes_pls_golite062009
channel activity 0.465630241372545 bayes_pls_golite062009
passive transmembrane transporter activity 0.465630241372545 bayes_pls_golite062009
substrate-specific channel activity 0.455589501590218 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.44519612509266 bayes_pls_golite062009
potassium channel activity 0.423464159542763 bayes_pls_golite062009
cation channel activity 0.406614358442595 bayes_pls_golite062009
voltage-gated cation channel activity 0.402494949667906 bayes_pls_golite062009
voltage-gated ion channel activity 0.39571309893169 bayes_pls_golite062009
ion channel activity 0.395022246697853 bayes_pls_golite062009
voltage-gated channel activity 0.387394052239826 bayes_pls_golite062009
voltage-gated potassium channel activity 0.326855275194847 bayes_pls_golite062009
gated channel activity 0.266124158878986 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [879-1117]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSGNMELPTY DMATMEGKGN QVPLSMNSDF FGNTCPPPPT FEEAISVPAS PIVSPMGSPN  60
   61 IMASYDPDLL SIQQLNLSRT TSVSGPSGYS DDAGVPNVNR NSISNANAMN GSISNSAFVS 120
  121 GNSGQGVARA RATSVNDRSR FNNLDKLLST PSPVNRSHNS SPTNGLSQAN GTVRIPNATT 180
  181 ENSKDKQNEF FKKGYTLANV KDDEEQEGIV SSSSADSLLS HGNEPPRYDE IVPLMSDEE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle