YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: ILS1
Organism: Saccharomyces cerevisiae
Length: 1072 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ILS1.

Description E-value Query
Range		 Subject
Range
IARS - isoleucyl-tRNA synthetase
 0.0 [1..1071] [6..1075]
gi|207347903 - gi|207347903|gb|EDZ73931.1| YBL076Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|151946322 - gi|151946322|gb|EDN64544.1| isoleucyl-tRNA synthetase [Saccharomyces cerevisiae YJM789]
ILS1 - Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A
SYIC_YEAST - Isoleucine--tRNA ligase, cytoplasmic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ILS...
 0.0 [1..1072] [1..1072]
gi|149728, gi|68525 - gi|68525|pir||SYEXI isoleucine-tRNA ligase (EC 6.1.1.5) [validated] - Methanobacterium thermoautotro...
SYI_METTM - Isoleucine--tRNA ligase OS=Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 /...
 0.0 [1..1070] [3..1042]
SYI_METTH - Isoleucine--tRNA ligase OS=Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JC...
gi|7437550 - pir||H69049 isoleucine-tRNA ligase (EC 6.1.1.5) - Methanobacterium thermoautotrophicum (strain Delta...
 0.0 [1..1072] [3..1044]
SYI_METBF - Isoleucine--tRNA ligase OS=Methanosarcina barkeri (strain Fusaro / DSM 804) GN=ileS PE=3 SV=1
gi|7648799 - gi|7648799|gb|AAF65673.1|AF208389_1 isoleucyl-tRNA synthetase [Methanosarcina barkeri]
 0.0 [1..1071] [2..1057]
SYI_CHLMU - Isoleucine--tRNA ligase OS=Chlamydia muridarum GN=ileS PE=3 SV=1
SYI_CHLMU - Isoleucine--tRNA ligase OS=Chlamydia muridarum (strain MoPn / Nigg) GN=ileS PE=3 SV=1
 0.0 [5..1070] [4..1032]
irs-1 - isoleucyl-tRNA synthetase status:Partially_confirmed UniProt:Q21926 protein_id:CAA94369.1
 0.0 [1..1043] [4..1034]
SYI_CHLTR - Isoleucine--tRNA ligase OS=Chlamydia trachomatis (strain D/UW-3/Cx) GN=ileS PE=3 SV=1
SYI_CHLTR - Isoleucine--tRNA ligase OS=Chlamydia trachomatis GN=ileS PE=3 SV=1
 0.0 [5..1072] [4..1034]

Back

Predicted Domain #1
Region A:
Residues: [1-40] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSESNAHFSF PKEEEKVLSL WDEIDAFHTS LELTKDKPEF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [53-80] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHYGHILAST IKDIVPRYAT MTGHHVER

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [131-142] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKTIGRLGRW ID

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [592-891] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGIVLAADGR KMSKSLKNYP DPSIVLNKYG ADALRLYLIN SPVLKAESLK FKEEGVKEVV  60
   61 SKVLLPWWNS FKFLDGQIAL LKKMSNIDFQ YDDSVKSDNV MDRWILASMQ SLVQFIHEEM 120
  121 GQYKLYTVVP KLLNFIDELT NWYIRFNRRR LKGENGVEDC LKALNSLFDA LFTFVRAMAP 180
  181 FTPFLSESIY LRLKEYIPEA VLAKYGKDGR SVHFLSYPVV KKEYFDEAIE TAVSRMQSVI 240
  241 DLGRNIREKK TISLKTPLKT LVILHSDESY LKDVEALKNY IIEELNVRDV VITSDEAKYG 300
  301

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2680.0
Match: 1ile__
Description: Isoleucyl-tRNA synthetase (IleRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ligase activity, forming aminoacyl-tRNA and related compounds 7.16276509815667 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 7.16276509815667 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 7.13957775963187 bayes_pls_golite062009
valine-tRNA ligase activity 7.13767629265822 bayes_pls_golite062009
leucine-tRNA ligase activity 7.03538514482698 bayes_pls_golite062009
isoleucine-tRNA ligase activity 6.38633897147986 bayes_pls_golite062009
ligase activity 6.11211476973434 bayes_pls_golite062009
glutamate-tRNA ligase activity 2.63681738794687 bayes_pls_golite062009
methionine-tRNA ligase activity 2.56893064485672 bayes_pls_golite062009
catalytic activity 2.37674226834122 bayes_pls_golite062009
tyrosine-tRNA ligase activity 1.88984817882585 bayes_pls_golite062009
arginine-tRNA ligase activity 1.50161401062914 bayes_pls_golite062009
tryptophan-tRNA ligase activity 1.14187887833901 bayes_pls_golite062009
cysteine-tRNA ligase activity 0.844943947059557 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.625793556381714 bayes_pls_golite062009
binding 0.485102284225571 bayes_pls_golite062009
nucleic acid binding 0.449504767632354 bayes_pls_golite062009
nucleotidyltransferase activity 0.2293846471193 bayes_pls_golite062009
glutamine-tRNA ligase activity 0.118292082006187 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [41-52] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFFDGPPFAT GT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [81-84] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RFGW

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [125-130] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TYASDW

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [143-147] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDNDY

[Run NCBI BLAST on this sequence.]

Region E:
Residues: [420-454] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKNIVPQMLD SVMKSHWVPN TIKEKRFANW IANAR

[Run NCBI BLAST on this sequence.]

Region F:
Residues: [539-591] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQHYPFENTE KFDERVPANF ISEGLDQTRG WFYTLAVLGT HLFGSVPYKN VIV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2680.0
Match: 1ile__
Description: Isoleucyl-tRNA synthetase (IleRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [85-124] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTHGVPIEHI IDKKLGITGK DDVFKYGLEN YNNECRSIVM

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [148-174] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTMYPSFMES TWWAFKQLHE KGQVYRG

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [415-419] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AWFVR

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [455-538] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DWNVSRNRYW GTPIPLWVSD DFEEVVCVGS IKELEELTGV RNITDLHRDV IDKLTIPSKQ  60
   61 GKGDLKRIEE VFDCWFESGS MPYA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2680.0
Match: 1ile__
Description: Isoleucyl-tRNA synthetase (IleRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [175-200] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FKVMPYSTGL TTPLSNFEAQ QNYKDV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [396-414] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSYPFCWRSD TPLLYRSVP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2680.0
Match: 1ile__
Description: Isoleucyl-tRNA synthetase (IleRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [201-395] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDPAVTIGFN VIGQEKTQLV AWTTTPWTLP SNLSLCVNAD FEYVKIYDET RDRYFILLES  60
   61 LIKTLYKKPK NEKYKIVEKI KGSDLVGLKY EPLFPYFAEQ FHETAFRVIS DDYVTSDSGT 120
  121 GIVHNAPAFG EEDNAACLKN GVISEDSVLP NAIDDLGRFT KDVPDFEGVY VKDADKLIIK 180
  181 YLTNTGNLLL ASQIR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2680.0
Match: 1ile__
Description: Isoleucyl-tRNA synthetase (IleRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [892-1072] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VEYKAVADWP VLGKKLKKDA KKVKDALPSV TSEQVREYLE SGKLEVAGIE LVKGDLNAIR  60
   61 GLPESAVQAG QETRTDQDVL IIMDTNIYSE LKSEGLAREL VNRIQKLRKK CGLEATDDVL 120
  121 VEYELVKDTI DFEAIVKEHF DMLSKTCRSD IAKYDGSKTD PIGDEEQSIN DTIFKLKVFK 180
  181 L

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle