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View Structure Prediction Details

Protein: PSK1
Organism: Saccharomyces cerevisiae
Length: 1356 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PSK1.

Description E-value Query
Range		 Subject
Range
PSK1 - One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein...
 0.0 [1..1356] [1..1356]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [1..1356] [1..1358]
KPCA_RAT - Protein kinase C alpha type OS=Rattus norvegicus GN=Prkca PE=1 SV=3
gi|56914 - gi|56914|emb|CAA30266.1| unnamed protein product [Rattus rattus]
 0.0 [943..1354] [199..597]
PRKCA - protein kinase C, alpha
gi|190692009, gi... - gi|254071371|gb|ACT64445.1| protein kinase C, alpha protein [synthetic construct], gi|190692009|gb|A...
HGNC:9393|MIM:17... - kinase C, alpha
 0.0 [943..1354] [199..597]
KPCA_BOVIN - Protein kinase C alpha type OS=Bos taurus GN=PRKCA PE=1 SV=3
 0.0 [943..1354] [199..597]
KPCA_RABIT - Protein kinase C alpha type OS=Oryctolagus cuniculus GN=PRKCA PE=2 SV=3
 0.0 [943..1354] [199..597]
gi|226574, gi|55132 - gi|55132|emb|CAA36907.1| protein kinase C [Mus musculus], gi|226574|prf||1602247A protein kinase C m...
 0.0 [943..1354] [199..597]
CDPK2_ARATH - Calcium-dependent protein kinase 2 OS=Arabidopsis thaliana GN=CPK2 PE=1 SV=1
 0.0 [907..1356] [18..446]
gi|4325024 - gi|4325024|gb|AAD17221.1| cAMP-dependent protein kinase catalytic subunit [Metarhizium anisopliae]
 0.0 [888..1354] [6..465]

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Predicted Domain #1
Region A:
Residues: [1-590] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPYIGASNLS EHSFVNLKEK HAITHKGTSS SVASLQTPPS PDQENHIDNE LENYDTSLSD  60
   61 VSTPNKKEGD EFQQSLRDTF ASFRKTKPPP PLDFEQPRLP STASSSVDST VSSPLTDEDI 120
  121 KELEFLPNES THSYSYNPLS PNSLAVRLRI LKRSLEIIIQ NPSMLLEPTP DDLPPLKEFA 180
  181 GRRSSLPRTS ASANHLMNRN KSQIWNTTSA TLNAFVNNTS SSSAASSALS NKKPGTPVFP 240
  241 NLDPTHSQTF HRANSLAYLP SILPEQDPLL KHNNSLFRGD YGNNISPERP SFRQPFKDQT 300
  301 SNLRNSSLLN ERAYQEDETF LPHHGPSMDL LNEQRANLKS LLNLLNETLE KNTSERASDL 360
  361 HMISLFNLNK LMLGDPKKNN SERDKRTEKL KKILLDSLAE PFFEHYNFIG DNPIADTDEL 420
  421 KEEIDEFTGS GDTTAITDIR PQQDYGRILR TFTSTKNSAP QAIFTCSQED PWQFRAANDL 480
  481 ACLVFGISQN AIRALTLMDL IHTDSRNFVL HKLLSTEGQE MVFTGEIIGI VQPETLSSSK 540
  541 VVWASFWAKR KNGLLVCVFE KVPCDYVDVL LNLDDFGAEN IVDKCELLSD

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.46
Match: 1qhbA
Description: Haloperoxidase (bromoperoxidase)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [591-912] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPTLSSSSTL SLPKMASSPT GSKLEYSLER KILEKSYTKP TSTENRNGDE NQLDGDSHSE  60
   61 PSLSSSPVRS KKSVKFANDI KDVKSISQSL AKLMDDVRNG VVFDPDDDLL PMPIKVCNHI 120
  121 NETRYFTLNH LSYNIPCAVS STVLEDELKL KIHSLPYQAG LFIVDSHTLD IVSSNKSILK 180
  181 NMFGYHFAEL VGKSITEIIP SFPKFLQFIN DKYPALDITL HKNKGLVLTE HFFRKIQAEI 240
  241 MGDRKSFYTS VGIDGLHRDG CEIKIDFQLR VMNSKVILLW VTHSRDVVFE EYNTNPSQLK 300
  301 MLKESELSLM SSASSSASSS KK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [913-1054] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSRISTGTL KDMSNLSTYE DLAHRTNKLK YEIGDDSRAH SQSTLSEQEQ VPLENDKDSG  60
   61 EMMLADPEMK HKLELARIYS RDKSQFVKEG NFKVDENLII SKISLSPSTE SLADSKSSGK 120
  121 GLSPLEEEKL IDENATENGL AG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.045757
Match: 1dsyA_
Description: C2 domain from protein kinase c (alpha)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [1055-1151] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPKDEDGIIM TNKRGNQPVS TFLRTPEKNI GAQKHVKKFS DFVSLQKMGE GAYGKVNLCI  60
   61 HKKNRYIVVI KMIFKERILV DTWVRDRKLG TIPSEIQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1167-1186] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLDFFEDDDY YYIETPVHGE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 319.9897
Match: 1fotA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1152-1166] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IMATLNKKPH ENILR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1187-1356] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGCIDLFDLI EFKTNMTEFE AKLIFKQVVA GIKHLHDQGI VHRDIKDENV IVDSKGFVKI  60
   61 IDFGSAAYVK SGPFDVFVGT IDYAAPEVLG GNPYEGQPQD IWAIGILLYT VVFKENPFYN 120
  121 IDEILEGDLK FNNAEEVSED CIELIKSILN RCVPKRPTID DINNDKWLVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 319.9897
Match: 1fotA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.27604928641749 bayes_pls_golite062009
DNA binding 3.83861939247274 bayes_pls_golite062009
nucleic acid binding 3.43738039086015 bayes_pls_golite062009
transcription factor activity 3.18442852449976 bayes_pls_golite062009
binding 3.0194696248926 bayes_pls_golite062009
transcription factor binding 2.22314179303094 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.13819142609078 bayes_pls_golite062009
transcription activator activity 1.8593473738006 bayes_pls_golite062009
protein kinase activity 1.64278494326255 bayes_pls_golite062009
protein binding 1.60673447924806 bayes_pls_golite062009
sequence-specific DNA binding 1.54935001412565 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.34369087457971 bayes_pls_golite062009
kinase activity 1.27787411134399 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.26593567694405 bayes_pls_golite062009
transcription cofactor activity 1.06445298547053 bayes_pls_golite062009
transcription coactivator activity 0.934727986222767 bayes_pls_golite062009
enzyme binding 0.902069383016175 bayes_pls_golite062009
protein heterodimerization activity 0.865848090169615 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.614755150740891 bayes_pls_golite062009
histone acetyltransferase binding 0.609670492126344 bayes_pls_golite062009
transferase activity 0.534003294436004 bayes_pls_golite062009
protein dimerization activity 0.3832620238984 bayes_pls_golite062009
substrate-specific transporter activity 0.184733508317397 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.119454387636252 bayes_pls_golite062009
transcription repressor activity 0.104316215089923 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.0413435093582974 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [906-1091] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SASSSKKSSS RISTGTLKDM SNLSTYEDLA HRTNKLKYEI GDDSRAHSQS TLSEQEQVPL  60
   61 ENDKDSGEMM LADPEMKHKL ELARIYSRDK SQFVKEGNFK VDENLIISKI SLSPSTESLA 120
  121 DSKSSGKGLS PLEEEKLIDE NATENGLAGS PKDEDGIIMT NKRGNQPVST FLRTPEKNIG 180
  181 AQKHVK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.69897
Match: 1dsyA
Description: C2 domain from protein kinase c (alpha)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.77482286467294 bayes_pls_golite062009
lipid binding 1.47484095830847 bayes_pls_golite062009
protein binding 1.33917246836907 bayes_pls_golite062009
phospholipid binding 0.98776359922762 bayes_pls_golite062009
calcium-dependent phospholipid binding 0.368277796845269 bayes_pls_golite062009
profilin binding 0.32399339703241 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1092-1356] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFSDFVSLQK MGEGAYGKVN LCIHKKNRYI VVIKMIFKER ILVDTWVRDR KLGTIPSEIQ  60
   61 IMATLNKKPH ENILRLLDFF EDDDYYYIET PVHGETGCID LFDLIEFKTN MTEFEAKLIF 120
  121 KQVVAGIKHL HDQGIVHRDI KDENVIVDSK GFVKIIDFGS AAYVKSGPFD VFVGTIDYAA 180
  181 PEVLGGNPYE GQPQDIWAIG ILLYTVVFKE NPFYNIDEIL EGDLKFNNAE EVSEDCIELI 240
  241 KSILNRCVPK RPTIDDINND KWLVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 111.0
Match: 2fh9A
Description: No description for 2fh9A was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle