YRC Public Data Repository - Protein Structure Prediction

Protein:	FOL1_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	686 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FOL1_SCHPO.

Description	E-value	Query Range	Subject Range
FOL1_PNECA - Folic acid synthesis protein fol1 OS=Pneumocystis carinii GN=fol1 PE=1 SV=1	663.0	[0..4]	[683..37]
gi\|23953859 - gi\|23953859\|gb\|AAN38834.1\| folic acid synthesis protein [Pneumocystis carinii f. sp. macaca]	646.0	[0..6]	[683..41]
gi\|55793070 - gi\|55793070\|gb\|AAV65581.1\| folic acid synthesis protein [synthetic construct]	640.0	[0..6]	[683..39]
gi\|49645561 - gi\|49645561\|emb\|CAG83619.1\| YALI0A02541p [Yarrowia lipolytica] gi\|50543060, gi\|... - gi\|50543060\|ref\|XP_499696.1\| YALI0A02541p [Yarrowia lipolytica], gi\|49645561\|emb\|CAG83619.1\| YALI0A0...	543.0	[0..6]	[685..23]
gi\|46435705, gi\|... - gi\|68483778\|ref\|XP_714164.1\| likely multifunctional folic acid biosynthesis enzyme [Candida albicans... orf19.8210 - FOL1 CGDID:CAL0000317 Assembly 19, Contig19-20057 (26147, 23781) CDS, reverse complemented, translat...	539.0	[0..3]	[683..2]
gi\|49077970, gi\|... - gi\|71022175\|ref\|XP_761318.1\| hypothetical protein UM05171.1 [Ustilago maydis 521], ref\|XP_402786.1\| ...	529.0	[0..6]	[684..12]
FOL1 - Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihyd... FOL1_YEAST - Folic acid synthesis protein FOL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FOL1 P... gi\|190409229 - gi\|190409229\|gb\|EDV12494.1\| dihydro-6-hydroxymethylpterin pyrophosphokinase [Saccharomyces cerevisia...	516.0	[0..4]	[683..20]
gi\|45199166, gi\|... - gi\|45199166\|ref\|NP_986195.1\| AFR647Cp [Ashbya gossypii ATCC 10895], gi\|44985306\|gb\|AAS54019.1\| AFR64... gi\|44985306 - gi\|44985306\|gb\|AAS54019.1\| AFR647Cp [Ashbya gossypii ATCC 10895]	498.0	[0..5]	[684..34]

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Predicted Domain #1

Region A:
Residues: [1-124]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLIHDTVVV ENLNTFAVVG QDQWKRKEPQ PVQIDVYMRN NVQLAGEKDE LKSTIHYGIA  60
   61 SKLLRKEIEG SFFTTPKDLV NKIASLCFED VIDTSHVSIK LTLPKCVLRS KNGLHYYAER 120
  121 ERNS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.154902
Match:	1dhnA
Description:	1.65 ANGSTROM RESOLUTION STRUCTURE OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTP cyclohydrolase I activity	4.1430878480831	bayes_pls_golite062009
cyclohydrolase activity	3.66553359909123	bayes_pls_golite062009
GTP cyclohydrolase activity	3.44912994722205	bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity	2.77658228107642	bayes_pls_golite062009
dihydroneopterin aldolase activity	2.51107306055654	bayes_pls_golite062009
catalytic activity	2.20788162511962	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.73101699306211	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.974891318710762	bayes_pls_golite062009
binding	0.641976427105342	bayes_pls_golite062009
oxidoreductase activity	0.0783540825826956	bayes_pls_golite062009
protein binding	0.045916344848404	bayes_pls_golite062009
urate oxidase activity	0.0294957696532921	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [125-244]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSNFVDRIEF SDLELATILG IHAFERQEKQ RVCLNISFAN TEVEALEIAR AIAEYVEQSA  60
   61 FLTIEALVVN LSKYLCFTKN LDDISIKAEK PSAITFANAS AVQIYRTRSY FLQESLHKYE 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.0
Match:	2cg8A
Description:	No description for 2cg8A was found.

Predicted Domain #3

Region A:
Residues: [245-686]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STKNKIAYLS FGSNIGDKFE QIQTALSMLH KIEGIRVLDV SPLYETEPMY YKDQPSFLNG  60
   61 VCKIETRMSP INLLRACQSI EQEMGRIKTI LKGPRCIDLD IVLYEDCVYE SEVLTIPHLG 120
  121 LQEREFVLRP LLALSPDLVH PYTHQPLQEA LDKLPSQGIR LYSSFDNKKI INGALTMGIL 180
  181 NVTPDSFSDG GKVSQNNILE KAKSMVGDGA SILDIGGQST KPGADPVSVE EELRRVIPMI 240
  241 SLLRSSGITV PISIDTYYSK VAKLAIEAGA NIINDVTGGM GDEKMLPLAA SLQVPICIMH 300
  301 MRGTPETMKA LSIYEKDIVE EVAVELSSRV EAAVQSGVHR YNIILDPGFG FAKTPKQSAG 360
  361 LLGRLHELMK KPQFKDMHWL SGPSRKGFTG YFTGDASPKD RIWGTSACVT ASVLQGVSIV 420
  421 RVHDTKEMSK VVGMANAIRY VP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	98.39794
Match:	2bmbA
Description:	X-ray structure of the bifunctional 6-hydroxymethyl-7,8- dihydroxypterin pyrophosphokinase dihydropteroate synthase from Sacchromyces cerevisiae
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: