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View Structure Prediction Details

Protein: chn-PC
Organism: Drosophila melanogaster
Length: 1214 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for chn-PC.

Description E-value Query
Range		 Subject
Range
gi|109458488 - gi|109458488|ref|XP_574414.2| PREDICTED: similar to Zinc finger protein 208 [Rattus norvegicus]
 1022.0 [0..8] [1037..306]

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Predicted Domain #1
Region A:
Residues: [1-145] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATLIPVNGG HPAASGQSSN VEATYEDMFK EITRKLYGEE TGNGLHTLGT PVAQVATSGP  60
   61 TAVPEGEQRS FTNLQQLDRS AAPSIEYESS AAGASGNNVA TTQANVIQQQ QQQQQQAESG 120
  121 NSVVVTASSG ATVVPAPSVA AVGGF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [146-384] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSEDHLSTAF GLAALMQNGF AAGQAGLLKA GEQQQRWAQD GSGLVAAAAA EPQLVQWTSG  60
   61 GKLQSYAHVN QQQQQQQQPH QSTPKSKKHR QEHAAELIYA SPSTSANAAQ NLAQSTPTSA 120
  121 PSNSSGGSTS SSGGGGGRKK AAQAAAAAAA ANGVHIQKRY ACTHCPYSTD RRDLYTRHEN 180
  181 IHKDEKPFQC YACLKQFNRA DHVKKHFLRM HRELQYDINK TRRHVSAGSG SSGSGSSGS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.522879
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #3
Region A:
Residues: [385-462] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSHHSGGRGN VTINSAGVNI DNAFLEAQRH PTSSSMSIVE TIEAVASATD MPLAQLKQEK  60
   61 MDDGAGVVLP LHVGVMQQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.0
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [463-610] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVASSSSGSS GSHGGNGNGG SGSGLLKPKR EKRFTCCYCP WSGADKWGLK RHLNTHTKPF  60
   61 VCLLCDYKAA RSERLATHVL KVHNKRACSK CSYLADTQEE YQAHMSDVHG NVGNANGGGG 120
  121 AVTIYTTTTN EGVAGGGGGG GGGISGNI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.0
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription activator activity 3.52873291636993 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
sequence-specific DNA binding 2.53101891154822 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
protein binding 2.05530362750351 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [611-676] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGGGPLQEII VNPSSMVGWR LSANGSLIPP HDLLTGGLPN AATQKRGSER LFQYLEAEGS  60
   61 DPEDYA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.69897
Match: 1bboA
Description: HIGH-RESOLUTION SOLUTION STRUCTURE OF THE DOUBLE CYS2*HIS2 ZINC FINGER FROM THE HUMAN ENHANCER BINDING PROTEIN MBP-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription activator activity 3.52873291636993 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
sequence-specific DNA binding 2.53101891154822 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
protein binding 2.05530362750351 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [677-760] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLLKMDAISR NTASVAQDFH KAGGVHELKI PANHQLLFNN KLPSQWTTRE AAALLYSLSN  60
   61 MGGGSASSVS GSQRQKFGMR ARQH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [761-949] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STGEDDENTP SSASSSSFSG DEFNMSATSP LKLSRHAIKL EKMDEMDAKD MGPTKAMMAT  60
   61 AFLEAANYEQ TAIELLASKR KIKVENDNDE DQENQQHQPH QQHHSQQQQQ QRLQLIKSSP 120
  121 AYKLNNNNNN NSNNNNYYKD KTSHRNAVHH HRQDDKENNK TKSPGTAAVS VAAAAATSPP 180
  181 SISGPSNQT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [950-1077] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFLTQMEYQN LNRIGTQFQN YVKDIINKYY AAETPLMLAA AAAALPTATT TGQQQQPELD  60
   61 IENLSPSKRR RLLSETEEYI EYLRNKEDIT LTIAPKVQPP APVTSLLKRQ LDLSTPRRSP 120
  121 KKAAPAHS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1078-1214] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSASNASRKS LNQLATLLPL LADAASQQEY LAAPLDFSKK SSSRKQAQPK KIRLTPEAVV  60
   61 TLLRDKYLNR MVRQRLGCLK CNQLRKNSSI SFNYHTLGSL ALHKYWRHGR LGSSSTRREK 120
  121 LQAALQKRIS RGQADKC

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle