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View Structure Prediction Details

Protein: alp-1
Organism: Caenorhabditis elegans
Length: 684 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for alp-1.

Description E-value Query
Range
Subject
Range
gi|76678552 - gi|76678552|ref|XP_583095.2| PREDICTED: similar to Zinc finger protein 268 (Zinc finger protein HZF3...
624.0 [0..57] [683..595]

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Predicted Domain #1
Region A:
Residues: [1-84]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERVTVRMAR SDRRTPWGFG VTEAPDGAVL IVNVIGGSLA DRAGLRNGDV VDRLEDLDNL  60
   61 DINAVDRLLV TAHEKIELIV TRQP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.522879
Match: 2uzcA
Description: No description for 2uzcA was found.

Predicted Domain #2
Region A:
Residues: [85-200]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGAATRIWRP EVTENTGPGQ DQTPYRVNLQ HSSDTRPPQG FNNSALPFET DQRVKHMQYN  60
   61 SPLGIYSDKS AAEQYVQQTQ GLGDNSGARA AAQRQDEPAY LRSETLRLLK EQEHGS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.22
Match: 1b8tA
Description: Cysteine-rich (intestinal) protein, CRP, CRIP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 3.16654971622305 bayes_pls_golite062009
binding 2.6699388818827 bayes_pls_golite062009
cytoskeletal protein binding 2.30646484446275 bayes_pls_golite062009
actin filament binding 1.88094478345266 bayes_pls_golite062009
transcription regulator activity 1.80598348040519 bayes_pls_golite062009
DNA binding 1.58803093726843 bayes_pls_golite062009
nucleic acid binding 1.40621128284718 bayes_pls_golite062009
protein binding 1.20339329058617 bayes_pls_golite062009
transcription factor activity 1.01977665301102 bayes_pls_golite062009
receptor activity 1.00000843633623 bayes_pls_golite062009
transporter activity 0.893102092384062 bayes_pls_golite062009
signal transducer activity 0.73994900849782 bayes_pls_golite062009
molecular transducer activity 0.73994900849782 bayes_pls_golite062009
transmembrane transporter activity 0.7072042577999 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.524388539161846 bayes_pls_golite062009
substrate-specific transporter activity 0.489535882040485 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 0.464305581802767 bayes_pls_golite062009
sequence-specific DNA binding 0.296594390687774 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.256518766904171 bayes_pls_golite062009
myosin binding 0.184990294745195 bayes_pls_golite062009
transcription activator activity 0.176489516931245 bayes_pls_golite062009
transcription factor binding 0.0944194708411399 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [201-418]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGGAGTTLSN HPNPSGLPVC FMCTRPILGV MARAAGKNLH GDCLSCATCG NSLRNVGHHF  60
   61 IEDKFYCDIH GTQRKHGGRP GMDPNIFVKS SPTAAQPVHI QDSPRAAYHP QVNTARPVSV 120
  121 SPAPSAGSKT VTTHYHTPKT QGILSPGQRG VPTAAFGADL SKSVTYGGGV GPGGTHYDSN 180
  181 RLSPAPSQYS TQSRNQSQQH YQQHVVQAPP PVPSNPPP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.3
Match: 2dfyX
Description: No description for 2dfyX was found.

Predicted Domain #4
Region A:
Residues: [419-489]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNDTTAEDSR NFLASRLGQV MIDENKKAGG SNGSSQHHNQ QGSSYTKTSF ERTTTETRPQ  60
   61 QNTGAPRAGD F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.30103
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [490-684]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGTGHLTTTT TTQQNGGRAP FCESCKQQIR GAFVLATGKS WCPEHFVCAN SSCRRRLLEC  60
   61 GFVEEDGQKF CESCFEQHIA PRCNKCSKPI ISDCLNALQK KWHPTCFTCA HCQKPFGNSA 120
  121 FYLEQGLPYC EQDWNALFTT KCVSCRYPIE AGDRWVEALG NAFHSNCFTC ARCNHNLEGE 180
  181 SFFAKNGQPF CRLHA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.09691
Match: 2i13A
Description: No description for 2i13A was found.

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