YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|481953, gi\|438212
Organism:	Plasmodium falciparum
Length:	910 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|481953, gi|438212.

Description	E-value	Query Range	Subject Range
gi\|68076635 - gi\|68076635\|ref\|XP_680237.1\| glucose-6-phosphatedehydrogenase-6- phosphogluconolactonase [Plasmodium... gi\|56501142 - gi\|56501142\|emb\|CAH98723.1\| glucose-6-phosphatedehydrogenase-6-phosphogluconolactonase, putative [Pl...	838.0	[0..1]	[908..1]
gi\|12381848 - gi\|12381848\|emb\|CAC24715.1\| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium ...	834.0	[0..1]	[908..1]
gi\|23482572 - gi\|23482572\|gb\|EAA18517.1\| Glucose-6-phosphate dehydrogenase, putative [Plasmodium yoelii yoelii] gi\|82705395 - gi\|82705395\|ref\|XP_726952.1\| glucose-6-phosphate dehydrogenase [Plasmodium yoelii yoelii str. 17XNL]	831.0	[0..1]	[908..1]
gi\|1090520, gi\|1... - gi\|160297\|gb\|AAA65930.1\| glucose-6-phosphate dehydrogenase, gi\|1090520\|prf\|\|2019249A glucose-6-phosp...	744.0	[0..188]	[910..12]
G6PD_CRIGR - Glucose-6-phosphate 1-dehydrogenase OS=Cricetulus griseus GN=G6PD PE=2 SV=3	669.0	[0..333]	[891..26]
G6PD_RAT - Glucose-6-phosphate 1-dehydrogenase OS=Rattus norvegicus GN=G6pdx PE=1 SV=3	669.0	[0..333]	[891..26]
gi\|74009187 - gi\|74009187\|ref\|XP_538209.2\| PREDICTED: similar to Glucose-6-phosphate 1-dehydrogenase (G6PD) [Canis...	667.0	[0..331]	[891..54]
gi\|163846094, gi... - gi\|76260057\|ref\|ZP_00767698.1\| Glucose-6-phosphate dehydrogenase [Chloroflexus aurantiacus J-10-fl],... gi\|222523829, gi... - gi\|222523829\|ref\|YP_002568299.1\| glucose-6-phosphate 1-dehydrogenase [Chloroflexus sp. Y-400-fl], gi...	667.0	[0..322]	[887..6]
gi\|109389365, gi... - gi\|119593090\|gb\|EAW72684.1\| glucose-6-phosphate dehydrogenase, isoform CRA_c [Homo sapiens], gi\|1093...	665.0	[0..333]	[891..56]
gi\|74138546 - gi\|74138546\|dbj\|BAE38077.1\| unnamed protein product [Mus musculus]	664.0	[0..333]	[891..26]

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Predicted Domain #1

Region A:
Residues: [1-297]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYENFVKSA EEINNLHNVN YLETKDLNDF NWKAAYYICK EIYDKQQINK DGYVVIGLSG  60
   61 GRTPIDVYKN MCLIKDIKID KSKLIFFIID ERYKSDDHKF SNYNNIKFLF HNLNINEKEQ 120
  121 LYKPDTTKSI VDCILDYNDK IKIMIEKYKK VDIAILGMGS DFHIASLFPN IFYNIYMNNY 180
  181 QNNYIYNEKT LDFINNDQDN DNLKYLKEYV YFTTTNQFDV RKRITVSLNL LANASSKIFL 240
  241 LNSKDKLDLW KNMLIKSYIE VNYNLYPATY LIDTSCTNEN VNINNNNNNN NKNKNNY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.221849
Match:	1ne7A
Description:	HUMAN GLUCOSAMINE-6-PHOSPHATE DEAMINASE ISOMERASE AT 1.75 A RESOLUTION COMPLEXED WITH N-ACETYL-GLUCOSAMINE-6-PHOSPHATE AND 2-DEOXY-2-AMINO-GLUCITOL-6-PHOSPHATE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ribose-5-phosphate isomerase activity	2.9184163250889	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	2.10773292255613	bayes_pls_golite062009
catalytic activity	1.68776709414398	bayes_pls_golite062009
transferase activity, transferring sulfur-containing groups	1.65060457499831	bayes_pls_golite062009
intramolecular oxidoreductase activity	1.63493703669467	bayes_pls_golite062009
6-phosphogluconolactonase activity	1.1599825493677	bayes_pls_golite062009
isomerase activity	0.61588631681492	bayes_pls_golite062009
binding	9.84508048393007E-4	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [298-910]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CYSNTTVISC GYENYTKSIE EIYDSKYALS LYSNSLNKEE LLTIIIFGCS GDLAKKKIYP  60
   61 ALFKLFCNNS LPKDLLIIGF ARTVQDFDTF FDKIVIYLKR CLLCYEDWSI SKKKDLLNGF 120
  121 KNRCRYFVGN YSSSESFENF NKYLTTIEEE EAKKKYYATC YKMNGSDYNI SNNVAEDNIS 180
  181 IDDENKTNEY FQMCTPKNCP DNVFSSNYNF PYVINRMLYL ALPPHIFVST LKNYKKNCLN 240
  241 SKGTDKILLE KPFGNDLDSF KMLSKQILEN FNEQQIYRID HYLGKDMVSG LLKLKFTNTF 300
  301 LLSLMNRHFI KCIKITLKET KGVYGRGQYF DPYGIIRDVM QNHMLQLLTL ITMEDPIDLN 360
  361 DESVKNEKIK ILKSIPSIKL EDTIIGQYEK AENFKEDENN DDESKKNHSY HDDPHIDKNS 420
  421 ITPTFCTCIL YINSINWYGV PIIFKSGKGL NKDICEIRIQ FHNIMGSSDE NMNNNEFVII 480
  481 LQPVEAIYLK MMIKKTGCEE MEEVQLNLTV NEKNKKINVP EAYETLLLEC FKGHKKKFIS 540
  541 DEELYESWRI FTPLLKELQE KQVKPLKYSF GSSGPKEVFG LVKKYYNYGK NYTHRPEFVR 600
  601 KSSFYEDDLL DIN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1qkiA
Description:	Glucose 6-phosphate dehydrogenase, N-terminal domain; Glucose 6-phosphate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glucose-6-phosphate dehydrogenase activity	2.90814647084155	bayes_pls_golite062009
catalytic activity	2.16785883389468	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.3919444853018	bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	1.37368669593547	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.27605103494323	bayes_pls_golite062009
aspartate-semialdehyde dehydrogenase activity	1.23689472371927	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.241113029381333	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	0.240794684270136	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: