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View Structure Prediction Details

Protein: gi|4688975
Organism: Plasmodium falciparum
Length: 909 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|4688975.

Description E-value Query
Range
Subject
Range
gi|7437043 - gi|7437043|pir||T10101 aconitate hydratase (EC 4.2.1.3) - cucurbit
gi|868003 - gi|868003|dbj|BAA06108.1| aconitase [Cucurbita cv. Kurokawa Amakuri]
ACOC_CUCMA - Aconitate hydratase, cytoplasmic OS=Cucurbita maxima PE=2 SV=1
1115.0 [0..12] [906..1]
ACOC_ORYSJ - Putative aconitate hydratase, cytoplasmic OS=Oryza sativa subsp. japonica GN=Os08g0191100 PE=3 SV=1
ACOC_ORYSA - Putative aconitate hydratase, cytoplasmic (EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase) - Oryza sat...
1112.0 [0..12] [904..1]
gi|11066033 - gi|11066033|gb|AAG28426.1|AF194945_1 cytosolic aconitase [Nicotiana tabacum]
1111.0 [0..12] [906..1]
gi|30407706 - gi|30407706|gb|AAP30039.1| aconitase [Lycopersicon pennellii]
1109.0 [0..12] [905..1]
ACO2M_ARATH - Aconitate hydratase 2, mitochondrial OS=Arabidopsis thaliana GN=ACO2 PE=1 SV=2
1107.0 [0..11] [906..92]
gi|3309243 - gi|3309243|gb|AAC26045.1| aconitase-iron regulated protein 1 [Citrus limon]
1094.0 [0..20] [906..11]
gi|108706066, gi... - gi|115450595|ref|NP_001048898.1| Os03g0136900 [Oryza sativa (japonica cultivar-group)], gi|113547369...
1092.0 [0..28] [906..107]

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Predicted Domain #1
Region A:
Residues: [1-909]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHFRRCIRKY CINKKIVNPF EHVQRTLNEK NYYYYDINEL HDSRIKSLPY SIRVLLESAV  60
   61 RNCDNLKVSE KNVETILGWK ENCKKKKEVP FMPTRVLLQD LTGVPCIVDL ATMRDTAEKL 120
  121 GCDAERINPL IPVDLVIDHS VQVDYSRRED ALELNEKKEY ERNLERFKFL KWGMNSFKNM 180
  181 LILPPGSGIV HQINLEYLAH CVFNKDNLLY PDSVVGTDSH TTMINGLGIL GWGVGGIEAE 240
  241 ATMLGLPISM TLPEVVGINV VGKLSDYLLS TDIVLYITSF LRKEVGVVNK YVEFFGTGLK 300
  301 DLKLADRATI SNMAPEYGAT VGFFPVDDIT LEYLLQTGRD KEKVELIREY LMKNSMFNTY 360
  361 KDNVEYTDVY TLDLSKLNLS LSGPKRPHDN VLLSELHKDF TMCLESPIGF KGYNIAKEER 420
  421 EKKISFVCSK DGKEYVLSQG SVVLCAITSC TNTSNSSSMI AAGLLAKKAI EEFGLKSLPY 480
  481 IKSSLSPGSK TVQKYLEAGG LLKYLEQLGF YNVGYGCMTC IGNSGHLDEE VEEVINKNDL 540
  541 IVSSVLSGNR NFEGRVHPLI KANYLASPVL VVLFSIIGNV NVDLSNYTFN YKGKKINALD 600
  601 LIPRKEEIEE YESTYIKPEM YTEIYKNIKY VNKYWNDIQI KKNKLYEWDK NSTYIHKPPY 660
  661 FENMTLEIEK IQDIKDAHVL LFLGDSITTD HISPAGMIHK TSEAYKFLKT KNIKDQDLNT 720
  721 YGARRGNDEV MIRGTFANIR LINKLCPDKG PNTIHIPTNQ LMSVYQAAMK YKQDNIDVII 780
  781 IAGKEYGCGS SRDWAAKGPN LLGVKAVIAE SYERIHRSNL IGMSVLPLQF INNQSPQYYN 840
  841 MDGTEKFTIL LNDGNIKAQQ TIKVQMNQKG KIIIFDVLCR IDTEIEERYF RNGGILKYVL 900
  901 RSLVNEANK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 2b3xA
Description: Structure of an orthorhombic crystal form of human cytosolic aconitase (IRP1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
3-isopropylmalate dehydratase activity 11.6597692115322 bayes_pls_golite062009
aconitate hydratase activity 5.86356477922338 bayes_pls_golite062009
structural constituent of ribosome 2.93956285477489 bayes_pls_golite062009
catalytic activity 2.4040324437254 bayes_pls_golite062009
nucleic acid binding 2.25736437672211 bayes_pls_golite062009
carbon-oxygen lyase activity 2.08349115784849 bayes_pls_golite062009
hydro-lyase activity 2.04845291489052 bayes_pls_golite062009
lyase activity 2.0080619912194 bayes_pls_golite062009
metal cluster binding 1.70706327499066 bayes_pls_golite062009
iron-sulfur cluster binding 1.70706327499066 bayes_pls_golite062009
binding 1.67914740974449 bayes_pls_golite062009
DNA binding 1.6436451615422 bayes_pls_golite062009
iron-responsive element binding 1.1980380564483 bayes_pls_golite062009
iron ion binding 1.12961684198784 bayes_pls_golite062009
4 iron, 4 sulfur cluster binding 1.11810757572823 bayes_pls_golite062009
mRNA binding 1.0310744464034 bayes_pls_golite062009
structural molecule activity 0.870913754566634 bayes_pls_golite062009
RNA binding 0.42311333660604 bayes_pls_golite062009
transition metal ion binding 0.342428816025605 bayes_pls_golite062009
protein binding 0.232638130896339 bayes_pls_golite062009
cation binding 0.0272064751959212 bayes_pls_golite062009
metal ion binding 0.0272064751959212 bayes_pls_golite062009
ion binding 0.0228992031160024 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle