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View Structure Prediction Details

Protein: gi|25289087, gi|...
Organism: Salmonella enterica subsp. enterica serovar Typhi
Length: 703 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|25289087, gi|....

Description E-value Query
Range
Subject
Range
gi|207858979, gi... - gi|207858979|ref|YP_002245630.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
gi|238910217 - gi|238910217|ref|ZP_04654054.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophospha...
gi|200388608, gi... - gi|200388608|ref|ZP_03215220.1| RelA/SpoT family protein [Salmonella enterica subsp. enterica serova...
gi|205354656, gi... - gi|205354656|ref|YP_002228457.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
gi|197364559, gi... - gi|197364559|ref|YP_002144196.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
gi|16422311, gi|... - gi|16767027|ref|NP_462642.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
gi|197937024, gi... - gi|198242508|ref|YP_002217702.1| GTP pyrophosphokinase [Salmonella enterica subsp. enterica serovar ...
gi|194711882, gi... - gi|194736380|ref|YP_002116685.1| GTP pyrophosphokinase [Salmonella enterica subsp. enterica serovar ...
lcl|NC_016856.1_... - [gene=spoT] [protein=bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrop...
gi|56415632, gi|... - gi|56415632|ref|YP_152707.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
gi|197215292, gi... - gi|197251589|ref|YP_002148673.1| GTP pyrophosphokinase [Salmonella enterica subsp. enterica serovar ...
gi|194449048, gi... - gi|194449048|ref|YP_002047773.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
gi|194471826, gi... - gi|194471826|ref|ZP_03077810.1| GTP pyrophosphokinase [Salmonella enterica subsp. enterica serovar K...
gi|168818426, gi... - gi|205344372|gb|EDZ31136.1| GTP pyrophosphokinase [Salmonella enterica subsp. enterica serovar Welte...
gi|194445787, gi... - gi|194445787|ref|YP_002042991.1| GTP pyrophosphokinase [Salmonella enterica subsp. enterica serovar ...
gi|205350323, gi... - gi|205350323|gb|EDZ36954.1| GTP pyrophosphokinase [Salmonella enterica subsp. enterica serovar Hadar...
gi|195632329, gi... - gi|195632329|gb|EDX50813.1| GTP pyrophosphokinase [Salmonella enterica subsp. enterica serovar Newpo...
gi|168235357, gi... - gi|197291311|gb|EDY30663.1| RelA/SpoT family protein [Salmonella enterica subsp. enterica serovar Sc...
gi|168241922, gi... - gi|205338906|gb|EDZ25670.1| RelA/SpoT family protein [Salmonella enterica subsp. enterica serovar He...
gi|205325687, gi... - gi|205325687|gb|EDZ13526.1| GTP pyrophosphokinase [Salmonella enterica subsp. enterica serovar Saint...
gi|168233267, gi... - gi|205332543|gb|EDZ19307.1| RelA/SpoT family protein [Salmonella enterica subsp. enterica serovar Ke...
gi|160867068, gi... - gi|161505721|ref|YP_001572833.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
gi|161616824, gi... - gi|161616824|ref|YP_001590789.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
gi|62129869, gi|... - gi|62182236|ref|YP_218653.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
0.0 [1..703] [1..703]
gi|81243289, gi|... - gi|82779141|ref|YP_405490.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
0.0 [1..703] [1..702]
gi|124528991, gi... - gi|124528991|ref|ZP_01700137.1| metal dependent phosphohydrolase [Escherichia coli B], gi|124500130|...
gi|24054163, gi|... - gi|24114920|ref|NP_709430.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
gi|168779806, gi... - gi|189002275|gb|EDU71261.1| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [Escherichia coli O157...
SPOT_SHIFL - Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase OS=Shigella flexneri GN=spoT PE=3 SV=1
gi|189374284, gi... - gi|189374284|gb|EDU92700.1| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [Escherichia coli O157...
SPOT_ECO57 - Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase OS=Escherichia coli O157:H7 GN=spoT PE=3 SV...
gi|168798620, gi... - gi|189378740|gb|EDU97156.1| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [Escherichia coli O157...
gi|30043335, gi|... - gi|30065074|ref|NP_839245.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
gi|170018120, gi... - gi|170018120|ref|YP_001723074.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
gi|15804191, gi|... - gi|15804191|ref|NP_290230.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
gi|13364000, gi|... - gi|15833779|ref|NP_312552.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
gi|170517691, gi... - gi|170679973|ref|YP_001745950.1| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [Escherichia coli...
EG10966 - bifunctional (p)ppGpp synthetase II / guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase / ppG...
gi|110617220, gi... - gi|110807672|ref|YP_691192.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate...
gi|195936211 - gi|195936211|ref|ZP_03081593.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophospha...
gi|208809066, gi... - gi|208809066|ref|ZP_03251403.1| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [Escherichia coli ...
gi|208735324, gi... - gi|208814047|ref|ZP_03255376.1| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [Escherichia coli ...
gi|188016940, gi... - gi|188016940|gb|EDU55062.1| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [Escherichia coli O157...
gi|189359047, gi... - gi|189359047|gb|EDU77466.1| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [Escherichia coli O157...
gi|168759771, gi... - gi|189369840|gb|EDU88256.1| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [Escherichia coli O157...
gi|168766071, gi... - gi|189364357|gb|EDU82776.1| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [Escherichia coli O157...
gi|168772381, gi... - gi|187771785|gb|EDU35629.1| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [Escherichia coli O157...
gi|218434381, gi... - gi|218707284|ref|YP_002414803.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
gi|254595005, gi... - gi|254795605|ref|YP_003080442.1| bifunctional (p)ppGpp synthetase II and guanosine-3',5'-bis pyropho...
gi|208740042, gi... - gi|208819919|ref|ZP_03260239.1| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [Escherichia coli ...
gi|226838816, gi... - gi|254038851|ref|ZP_04872903.1| guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [Escherichi...
gi|209162363, gi... - gi|209400963|ref|YP_002273130.1| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [Escherichia coli...
gi|209914382, gi... - gi|209921123|ref|YP_002295207.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
gi|215488945, gi... - gi|215488945|ref|YP_002331376.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
EG10966 - bifunctional (p)ppGpp synthetase II / guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase / ppG...
gi|217322802, gi... - gi|217326581|ref|ZP_03442665.1| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [Escherichia coli ...
gi|218362981, gi... - gi|218556213|ref|YP_002389126.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
SPOT_ECOLI - Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) ((ppGpp)ase) (Penta-phosphate ...
gi|218697371, gi... - gi|218697371|ref|YP_002405038.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
gi|218702419, gi... - gi|218702419|ref|YP_002410048.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
gi|73857592, gi|... - gi|74314115|ref|YP_312534.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
gi|81247492, gi|... - gi|82546081|ref|YP_410028.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
gi|75258191, gi|... - gi|75258191|ref|ZP_00729639.1| COG0317: Guanosine polyphosphate pyrophosphohydrolases/synthetases [E...
gi|188494223, gi... - gi|75514287|ref|ZP_00736595.1| COG0317: Guanosine polyphosphate pyrophosphohydrolases/synthetases [E...
gi|85676393, gi|... - gi|89110362|ref|AP_004142.1| bifunctional (p)ppGpp synthetase II and guanosine-3',5'-bis pyrophospha...
gi|83588503, gi|... - gi|83588503|ref|ZP_00927127.1| COG0317: Guanosine polyphosphate pyrophosphohydrolases/synthetases [E...
gi|75179691, gi|... - gi|75179691|ref|ZP_00699678.1| COG0317: Guanosine polyphosphate pyrophosphohydrolases/synthetases [S...
gi|194420599, gi... - gi|83571437|ref|ZP_00922877.1| COG0317: Guanosine polyphosphate pyrophosphohydrolases/synthetases [S...
gi|190902152, gi... - gi|75229041|ref|ZP_00715625.1| COG0317: Guanosine polyphosphate pyrophosphohydrolases/synthetases [E...
gi|193070400, gi... - gi|75234808|ref|ZP_00719111.1| COG0317: Guanosine polyphosphate pyrophosphohydrolases/synthetases [E...
gi|157078900, gi... - gi|75188408|ref|ZP_00701675.1| COG0317: Guanosine polyphosphate pyrophosphohydrolases/synthetases [E...
gi|75197553, gi|... - gi|75197553|ref|ZP_00707623.1| COG0317: Guanosine polyphosphate pyrophosphohydrolases/synthetases [E...
0.0 [1..703] [1..702]
gi|37524291, gi|... - gi|37524291|ref|NP_927635.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
0.0 [1..703] [1..705]
gi|91213168, gi|... - gi|91213168|ref|YP_543154.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
gi|190909368, gi... - gi|75242571|ref|ZP_00726315.1| COG0317: Guanosine polyphosphate pyrophosphohydrolases/synthetases [E...
gi|226902708, gi... - gi|237703444|ref|ZP_04533925.1| guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [Escherichi...
gi|218367491, gi... - gi|218560722|ref|YP_002393635.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
gi|110643891, gi... - gi|110643891|ref|YP_671621.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate...
gi|26110727, gi|... - gi|26250297|ref|NP_756337.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
0.0 [1..703] [1..702]
gi|75208678, gi|... - gi|75208678|ref|ZP_00708975.1| COG0317: Guanosine polyphosphate pyrophosphohydrolases/synthetases [E...
0.0 [1..703] [1..702]
gi|25289086 - pir||AG0005 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase (EC 3.1.7.2) [imported] - Yersinia pes...
gi|45434759, gi|... - gi|45439904|ref|NP_991443.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
gi|22124023, gi|... - gi|22124023|ref|NP_667446.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
gi|15978153, gi|... - gi|218927259|ref|YP_002345134.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
gi|51594393, gi|... - gi|51594393|ref|YP_068584.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate ...
Q66GE7|Q66GE7_YERPS - Guanosine-3',5'-bisbis(Diphosphate) 3'-pyrophosphydrolase - Yersinia pseudotuberculosis
gi|229690279, gi... - gi|229841969|ref|ZP_04462124.1| guanosine-3',5'-bisbis(diphosphate) 3'-pyrophosphydrolase [Yersinia ...
gi|229839887, gi... - gi|229839887|ref|ZP_04460046.1| guanosine-3',5'-bisbis(diphosphate) 3'-pyrophosphydrolase [Yersinia ...
gi|229836149, gi... - gi|229836149|ref|ZP_04456317.1| guanosine-3',5'-bisbis(diphosphate) 3'-pyrophosphydrolase [Yersinia ...
gi|165922010, gi... - gi|165926150|ref|ZP_02221982.1| guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [Yersinia p...
gi|165989604, gi... - gi|166011458|ref|ZP_02232356.1| guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [Yersinia p...
gi|166205143, gi... - gi|166213741|ref|ZP_02239776.1| guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [Yersinia p...
gi|167048468, gi... - gi|167402093|ref|ZP_02307570.1| guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [Yersinia p...
gi|166962709, gi... - gi|167418715|ref|ZP_02310468.1| guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [Yersinia p...
gi|167426657, gi... - gi|167426657|ref|ZP_02318410.1| guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [Yersinia p...
gi|162419160, gi... - gi|77634083|ref|ZP_00796192.1| COG0317: Guanosine polyphosphate pyrophosphohydrolases/synthetases [Y...
gi|117671878, gi... - gi|77630893|ref|ZP_00793479.1| COG0317: Guanosine polyphosphate pyrophosphohydrolases/synthetases [Y...
gi|167468214 - gi|167468214|ref|ZP_02332918.1| guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [Yersinia p...
gi|169752919, gi... - gi|170026385|ref|YP_001722890.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
gi|186893380, gi... - gi|186893380|ref|YP_001870492.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
gi|89102582, gi|... - gi|89102582|ref|ZP_01175205.1| COG0317: Guanosine polyphosphate pyrophosphohydrolases/synthetases [Y...
gi|108781408, gi... - gi|108809495|ref|YP_653411.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate...
gi|229678620, gi... - gi|229904502|ref|ZP_04519613.1| guanosine-3',5'-bisbis(diphosphate) 3'-pyrophosphydrolase [Yersinia ...
gi|150260898, gi... - gi|150260898|ref|ZP_01917626.1| guanosine-3',5'-bisbis(diphosphate) 3'-pyrophosphydrolase [Yersinia ...
gi|145601107, gi... - gi|145601107|ref|YP_001165183.1| bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosph...
0.0 [1..703] [1..702]
gi|73671332 - gi|73671332|gb|AAZ80077.1| SpoT [Escherichia coli]
gi|73671332|gb|A... - SpoT [Escherichia coli]
0.0 [1..703] [1..704]
gi|20516195, gi|... - gi|20807650|ref|NP_622821.1| guanosine polyphosphate pyrophosphohydrolase/synthetase [Thermoanaeroba...
gi|20807650 - gi|20807650|ref|NP_622821.1| Guanosine polyphosphate pyrophosphohydrolase/synthetase [Thermoanaeroba...
0.0 [3..702] [1..717]
gi|238715125, gi... - gi|77958430|ref|ZP_00822463.1| COG0317: Guanosine polyphosphate pyrophosphohydrolases/synthetases [Y...
0.0 [1..703] [1..700]

Back

Predicted Domain #1
Region A:
Residues: [1-383]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYLFESLNQL IQTYLPEDQI KRLRQAYLVA RDAHEGQTRS SGEPYITHPV AVACILAEMK  60
   61 LDYETLMAAL LHDVIEDTPA TYQDMEQLFG KSVAELVEGV SKLDKLKFRD KKEAQAENFR 120
  121 KMIMAMVQDI RVILIKLADR THNMRTLGSL RPDKRRRIAR ETLEIYSPLA HRLGIHHIKT 180
  181 ELEELGFEAL YPNRYRVIKE VVRAARGNRK EMIQKILSEI EGRLQEAGIP CRVSGREKHL 240
  241 YSIYCKMVLK EQRFHSIMDI YAFRVIVHDS DTCYRVLGQM HSLYKPRPGR VKDYIAIPKA 300
  301 NGYQSLHTSM IGPHGVPVEV QIRTEDMDQM AEMGVAAHWA YKEHGETSTT AQIRAQRWMQ 360
  361 SLLELQQSAG SSFEFIESVK SDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 134.0
Match: 1vj7A
Description: Crystal structure of the bifunctional catalytic fragment of RelSeq, the RelA/SpoT homolog from Streptococcus equisimilis.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTP diphosphokinase activity 1.5953523101767 bayes_pls_golite062009
cyclic-nucleotide phosphodiesterase activity 1.53556412385088 bayes_pls_golite062009
3',5'-cyclic-nucleotide phosphodiesterase activity 1.52960140313397 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.17940277430091 bayes_pls_golite062009
guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity 1.1479499593037 bayes_pls_golite062009
diphosphoric monoester hydrolase activity 1.1479499593037 bayes_pls_golite062009
catalytic activity 1.122769147009 bayes_pls_golite062009
nucleotidyltransferase activity 0.92178707322923 bayes_pls_golite062009
hydrolase activity 0.89382287998944 bayes_pls_golite062009
phosphoric diester hydrolase activity 0.874654356902841 bayes_pls_golite062009
transferase activity 0.63270331673446 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.262138492248739 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.196287846714023 bayes_pls_golite062009
3',5'-cyclic-AMP phosphodiesterase activity 0.0897894719596 bayes_pls_golite062009
3',5'-cyclic-GMP phosphodiesterase activity 0.0229959143092802 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [384-621]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FPDEIYVFTP EGRIVELPAG ATPVDFAYAV HTDIGHACVG ARVDRQPYPL SQPLSSGQTV  60
   61 EIITAPGARP NAAWLNFVVS SKARAKIRQL LKNLKRDDSV SLGRRLLNHA LGGSRKLAEI 120
  121 PQENIQRELD RMKLATLDDL LAEIGLGNAM SVVVAKNLQQ GEAVVPTVAQ SNHGHLPIKG 180
  181 ADGVLITFAK CCRPIPGDPI IAHVSPGKGL VIHHESCRNI RGYQKEPEKF MAVEWDKE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.154902
Match: 1qf6A
Description: Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [622-703]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEQEFITEIK VEMFNHQGAL ANLTAAINTT TSNIQSLNTE EKDGRVYSTF IRLTARDRVH  60
   61 LANIMRKIRV MPDVIKVTRN RN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.522879
Match: 2f1fA
Description: Crystal structure of the regulatory subunit of acetohydroxyacid synthase isozyme III from E. coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transferase activity, transferring aldehyde or ketonic groups 1.58611270031811 bayes_pls_golite062009
catalytic activity 1.01569611874813 bayes_pls_golite062009
binding 0.162590183060409 bayes_pls_golite062009
transferase activity 0.07375530569672 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle