YRC Public Data Repository - Protein Structure Prediction

Protein:	EG10618
Organism:	Escherichia coli K-12
Length:	1486 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EG10618.

Description	E-value	Query Range	Subject Range
MUKB_ECOL6 - Chromosome partition protein MukB OS=Escherichia coli O6 GN=mukB PE=3 SV=1 gi\|227838863, gi... - gi\|227884111\|ref\|ZP_04001916.1\| cell division protein MukB [Escherichia coli 83972], gi\|227838863\|gb... MUKB_ECOL6 - Chromosome partition protein MukB OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=...	549.0	[0..1]	[1486..1]
gi\|75512080, gi\|... - gi\|75512080\|ref\|ZP_00734665.1\| COG3096: Uncharacterized protein involved in chromosome partitioning ... gi\|83585867, gi\|... - gi\|83585867\|ref\|ZP_00924507.1\| COG3096: Uncharacterized protein involved in chromosome partitioning ... gi\|253977153, gi... - gi\|254287846\|ref\|YP_003053594.1\| cell division protein MukB [Escherichia coli BL21(DE3)], gi\|2539771... gi\|242376739, gi... - gi\|251784466\|ref\|YP_002998770.1\| hypothetical protein B21_00935 [Escherichia coli BL21], gi\|24237673... MUKB_ECOLC - Chromosome partition protein MukB OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=mukB... gi\|254161038, gi... - gi\|254161038\|ref\|YP_003044146.1\| cell division protein MukB [Escherichia coli B str. REL606], gi\|253...	548.0	[0..1]	[1486..1]
gi\|254591523, gi... - gi\|254792123\|ref\|YP_003076960.1\| predicted bifunctional chromosome partitioning protein and nucleoti... gi\|208807903, gi... - gi\|208807903\|ref\|ZP_03250240.1\| chromosome partition protein MukB [Escherichia coli O157:H7 str. EC4... MUKB_ECO57 - Chromosome partition protein MukB OS=Escherichia coli O157:H7 GN=mukB PE=3 SV=1 gi\|189372659, gi... - gi\|189372659\|gb\|EDU91075.1\| chromosome partition protein MukB [Escherichia coli O157:H7 str. EC869],... gi\|208737833, gi... - gi\|208822348\|ref\|ZP_03262667.1\| chromosome partition protein MukB [Escherichia coli O157:H7 str. EC4... gi\|208731445, gi... - gi\|208814797\|ref\|ZP_03255976.1\| chromosome partition protein MukB [Escherichia coli O157:H7 str. EC4... gi\|217325399, gi... - gi\|217325399\|ref\|ZP_03441483.1\| chromosome partition protein MukB [Escherichia coli O157:H7 str. TW1... MUKB_ECO5E - Chromosome partition protein MukB OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=mukB PE=3 SV... MUKB_ECO8A - Chromosome partition protein MukB OS=Escherichia coli O8 (strain IAI1) GN=mukB PE=3 SV=1 gi\|25308123 - pir\|\|G90754 kinesin-like cell division protein MukB [imported] - Escherichia coli (strain O157:H7, s... gi\|168751188, gi... - gi\|188014730\|gb\|EDU52852.1\| chromosome partition protein MukB [Escherichia coli O157:H7 str. EC4113]... gi\|75229870, gi\|... - gi\|75229870\|ref\|ZP_00716393.1\| COG3096: Uncharacterized protein involved in chromosome partitioning ... gi\|189366817, gi... - gi\|189366817\|gb\|EDU85233.1\| chromosome partition protein MukB [Escherichia coli O157:H7 str. EC4501]... gi\|13360466, gi\|... - gi\|15830261\|ref\|NP_309034.1\| cell division protein MukB [Escherichia coli O157:H7 str. Sakai], gi\|13... gi\|189355940, gi... - gi\|189355940\|gb\|EDU74359.1\| chromosome partition protein MukB [Escherichia coli O157:H7 str. EC4401]... gi\|168784122, gi... - gi\|188998648\|gb\|EDU67634.1\| chromosome partition protein MukB [Escherichia coli O157:H7 str. EC4076]... gi\|189361130, gi... - gi\|189361130\|gb\|EDU79549.1\| chromosome partition protein MukB [Escherichia coli O157:H7 str. EC4486]...	548.0	[0..1]	[1486..1]
MUKB_ECOSE - Chromosome partition protein MukB OS=Escherichia coli (strain SE11) GN=mukB PE=3 SV=1 MUKB_ECO55 - Chromosome partition protein MukB OS=Escherichia coli (strain 55989 / EAEC) GN=mukB PE=3 SV=1 MUKB_ECO24 - Chromosome partition protein MukB OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=mukB PE=3 ...	548.0	[0..1]	[1486..1]
gi\|192955930, gi... - gi\|75234393\|ref\|ZP_00718754.1\| COG3096: Uncharacterized protein involved in chromosome partitioning ...	548.0	[0..1]	[1486..1]
gi\|190907652, gi... - gi\|75240999\|ref\|ZP_00724888.1\| COG3096: Uncharacterized protein involved in chromosome partitioning ... MUKB_ECOL5 - Chromosome partition protein MukB OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=mukB PE=3 SV...	548.0	[0..1]	[1486..1]
MUKB_ECOK1 - Chromosome partition protein MukB OS=Escherichia coli O1:K1 / APEC GN=mukB PE=3 SV=1 gi\|226898298, gi... - gi\|237707088\|ref\|ZP_04537569.1\| cell division protein MukB [Escherichia sp. 3_2_53FAA], gi\|226898298... MUKB_ECOUT - Chromosome partition protein MukB OS=Escherichia coli (strain UTI89 / UPEC) GN=mukB PE=3 SV=1 MUKB_ECO45 - Chromosome partition protein MukB OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=mukB PE=3 SV=1	548.0	[0..1]	[1486..1]
gi\|12514096, gi\|... - gi\|15800785\|ref\|NP_286799.1\| cell division protein MukB [Escherichia coli O157:H7 EDL933], gi\|125140... gi\|25308126 - pir\|\|E85618 hypothetical protein mukB [imported] - Escherichia coli (strain O157:H7, substrain EDL9...	548.0	[0..1]	[1486..1]
gi\|75257360, gi\|... - gi\|75257360\|ref\|ZP_00728876.1\| COG3096: Uncharacterized protein involved in chromosome partitioning ...	548.0	[0..1]	[1486..1]
MUKB_SHISS - Chromosome partition protein MukB OS=Shigella sonnei (strain Ss046) GN=mukB PE=3 SV=1	548.0	[0..1]	[1486..1]

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Predicted Domain #1

Region A:
Residues: [1-168]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIERGKFRSL TLINWNGFFA RTFDLDELVT TLSGGNGAGK STTMAAFVTA LIPDLTLLHF  60
   61 RNTTEAGATS GSRDKGLHGK LKAGVCYSML DTINSRHQRV VVGVRLQQVA GRDRKVDIKP 120
  121 FAIQGLPMSV QPTQLVTETL NERQARVLPL NELKDKLEAM EGVQFKQF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.221849
Match:	1qhlA
Description:	Cell division protein MukB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA-dependent ATPase activity	2.58390156971125	bayes_pls_golite062009
binding	2.0681607836408	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.94405657559372	bayes_pls_golite062009
pyrophosphatase activity	1.87046999221652	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.85030653553169	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.84811666933472	bayes_pls_golite062009
DNA helicase activity	1.72320119360938	bayes_pls_golite062009
ATP-dependent DNA helicase activity	1.52935820732225	bayes_pls_golite062009
structure-specific DNA binding	1.20578879155031	bayes_pls_golite062009
DNA clamp loader activity	1.18022389527356	bayes_pls_golite062009
motor activity	1.14667913749579	bayes_pls_golite062009
hydrolase activity	0.985656549643169	bayes_pls_golite062009
chromatin binding	0.741267272072522	bayes_pls_golite062009
protein-DNA loading ATPase activity	0.707571682109441	bayes_pls_golite062009
helicase activity	0.66186162189254	bayes_pls_golite062009
microtubule motor activity	0.60036517876321	bayes_pls_golite062009
cytoskeletal protein binding	0.500462538667228	bayes_pls_golite062009
catalytic activity	0.458437698837681	bayes_pls_golite062009
protein binding	0.378225828131122	bayes_pls_golite062009
purine nucleotide binding	0.370109410491501	bayes_pls_golite062009
nucleotide binding	0.367488441096941	bayes_pls_golite062009
purine ribonucleotide binding	0.348507955395744	bayes_pls_golite062009
ribonucleotide binding	0.348454114797054	bayes_pls_golite062009
centromeric DNA binding	0.322818640526369	bayes_pls_golite062009
ATP-dependent helicase activity	0.26149028591882	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.26149028591882	bayes_pls_golite062009
actin binding	0.00482938540552702	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [169-488]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSITDYHSLM FDLGIIARRL RSASDRSKFY RLIEASLYGG ISSAITRSLR DYLLPENSGV  60
   61 RKAFQDMEAA LRENRMTLEA IRVTQSDRDL FKHLISEATN YVAADYMRHA NERRVHLDKA 120
  121 LEFRRELHTS RQQLAAEQYK HVDMARELAE HNGAEGDLEA DYQAASDHLN LVQTALRQQE 180
  181 KIERYEADLD ELQIRLEEQN EVVAEAIERQ QENEARAEAA ELEVDELKSQ LADYQQALDV 240
  241 QQTRAIQYNQ AIAALNRAKE LCHLPDLTAD CAAEWLETFQ AKELEATEKM LSLEQKMSMA 300
  301 QTAHSQFEQA YQLVVAINGP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.69897
Match:	1c1gA
Description:	Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [489-768]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LARNEAWDVA RELLREGVDQ RHLAEQVQPL RMRLSELEQR LREQQEAERL LADFCKRQGK  60
   61 NFDIDELEAL HQELEARIAS LSDSVSNARE ERMALRQEQE QLQSRIQSLM QRAPVWLAAQ 120
  121 NSLNQLSEQC GEEFTSSQDV TEYLQQLLER EREAIVERDE VGARKNAVDE EIERLSQPGG 180
  181 SEDQRLNALA ERFGGVLLSE IYDDVSLEDA PYFSALYGPS RHAIVVPDLS QVTEHLEGLT 240
  241 DCPEDLYLIE GDPQSFDDSV FSVDELEKAV VVKIADRQWR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [769-1028]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSRFPEVPLF GRAARESRIE SLHAEREVLS ERFATLSFDV QKTQRLHQAF SRFIGSHLAV  60
   61 AFESDPEAEI RQLNSRRVEL ERALSNHEND NQQQRIQFEQ AKEGVTALNR ILPRLNLLAD 120
  121 DSLADRVDEI RERLDEAQEA ARFVQQFGNQ LAKLEPIVSV LQSDPEQFEQ LKEDYAYSQQ 180
  181 MQRDARQQAF ALTEVVQRRA HFSYSDSAEM LSGNSDLNEK LRERLEQAEA ERTRAREALR 240
  241 GHAAQLSQYN QVLASLKSSY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.522879
Match:	2i1jA
Description:	No description for 2i1jA was found.

Predicted Domain #5

Region A:
Residues: [1029-1486]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTKKELLNDL QRELQDIGVR ADSGAEERAR IRRDELHAQL SNNRSRRNQL EKALTFCEAE  60
   61 MDNLTRKLRK LERDYFEMRE QVVTAKAGWC AVMRMVKDNG VERRLHRREL AYLSADDLRS 120
  121 MSDKALGALR LAVADNEHLR DVLRMSEDPK RPERKIQFFV AVYQHLRERI RQDIIRTDDP 180
  181 VEAIEQMEIE LSRLTEELTS REQKLAISSR SVANIIRKTI QREQNRIRML NQGLQNVSFG 240
  241 QVNSVRLNVN VRETHAMLLD VLSEQHEQHQ DLFNSNRLTF SEALAKLYQR LNPQIDMGQR 300
  301 TPQTIGEELL DYRNYLEMEV EVNRGSDGWL RAESGALSTG EAIGTGMSIL VMVVQSWEDE 360
  361 SRRLRGKDIS PCRLLFLDEA ARLDARSIAT LFELCERLQM QLIIAAPENI SPEKGTTYKL 420
  421 VRKVFQNTEH VHVVGLRGFA PQLPETLPGT DEAPSQAS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.45
Match:	1w1wA
Description:	Sc Smc1hd:Scc1-C complex, ATPgS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA-dependent ATPase activity	2.36983712933522	bayes_pls_golite062009
binding	2.00435458244286	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.66824971329829	bayes_pls_golite062009
pyrophosphatase activity	1.59870547004658	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.57961205729121	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.57748131423105	bayes_pls_golite062009
DNA helicase activity	1.51954235333573	bayes_pls_golite062009
ATP-dependent DNA helicase activity	1.3221413719082	bayes_pls_golite062009
structure-specific DNA binding	1.12089515412415	bayes_pls_golite062009
DNA clamp loader activity	0.977237730484575	bayes_pls_golite062009
motor activity	0.934327429601554	bayes_pls_golite062009
hydrolase activity	0.811278135971081	bayes_pls_golite062009
chromatin binding	0.748204320980307	bayes_pls_golite062009
protein-DNA loading ATPase activity	0.499964948268718	bayes_pls_golite062009
cytoskeletal protein binding	0.482433345604081	bayes_pls_golite062009
helicase activity	0.431828833187431	bayes_pls_golite062009
protein binding	0.409258528033042	bayes_pls_golite062009
catalytic activity	0.400036839701206	bayes_pls_golite062009
microtubule motor activity	0.381564091226657	bayes_pls_golite062009
centromeric DNA binding	0.248124491570334	bayes_pls_golite062009
purine nucleotide binding	0.15435325982346	bayes_pls_golite062009
nucleotide binding	0.153440379095025	bayes_pls_golite062009
purine ribonucleotide binding	0.130523976113733	bayes_pls_golite062009
ribonucleotide binding	0.130518519278213	bayes_pls_golite062009
ATP-dependent helicase activity	0.0304447040261648	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.0304447040261648	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: