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View Structure Prediction Details

Protein: ATCU_ECOLI
Organism: Escherichia coli
Length: 834 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATCU_ECOLI.

Description E-value Query
Range
Subject
Range
gi|94972021, gi|... - gi|94972021|ref|YP_594061.1| heavy metal translocating P-type ATPase [Deinococcus geothermalis DSM 1...
696.0 [0..1] [833..1]
gi|42782808, gi|... - gi|42782808|ref|NP_980055.1| heavy metal-transporting ATPase [Bacillus cereus ATCC 10987], gi|427387...
695.0 [0..3] [833..5]
gi|145408869, gi... - gi|82499630|ref|ZP_00885070.1| ATPase, E1-E2 type:Copper ion-binding:Copper-translocating P-type ATP...
693.0 [0..3] [834..2]
gi|56419437, gi|... - gi|56419437|ref|YP_146755.1| heavy metal-transporting ATPase [Geobacillus kaustophilus HTA426], gi|5...
691.0 [0..3] [831..5]
COPA_BACSU - Copper-exporting P-type ATPase A OS=Bacillus subtilis GN=copA PE=1 SV=1
gi|2635863, gi|1... - gi|2635863|emb|CAB15355.1| yvgX [Bacillus subtilis subsp. subtilis str. 168], gi|16080403|ref|NP_391...
690.0 [0..3] [831..6]
gi|29374937, gi|... - gi|29374937|ref|NP_814090.1| copper-translocating P-type ATPase [Enterococcus faecalis V583], gi|293...
689.0 [0..3] [832..2]
gi|242258479, gi... - gi|242258479|ref|ZP_04803277.1| copper-translocating P-type ATPase [Thermoanaerobacter sp. X513], gi...
gi|241903577, gi... - gi|241903577|ref|ZP_04788299.1| copper-translocating P-type ATPase [Thermoanaerobacter brockii subsp...
gi|76588523, gi|... - gi|76796112|ref|ZP_00778480.1| ATPase, E1-E2 type:Copper ion-binding:Copper-translocating P-type ATP...
gi|114844533, gi... - gi|167039429|ref|YP_001662414.1| copper-translocating P-type ATPase [Thermoanaerobacter sp. X514], g...
686.0 [0..1] [831..1]
gi|20808818 - gi|20808818|ref|NP_623989.1| Cation transport ATPase [Thermoanaerobacter tengcongensis MB4]
gi|20517469, gi|... - gi|20808818|ref|NP_623989.1| cation transport ATPase [Thermoanaerobacter tengcongensis MB4], gi|2051...
683.0 [0..1] [831..1]
COPA_STAAS - Copper-exporting P-type ATPase A OS=Staphylococcus aureus (strain MSSA476) GN=copA PE=3 SV=1
COPA_STAAW - Copper-exporting P-type ATPase A OS=Staphylococcus aureus (strain MW2) GN=copA PE=3 SV=1
gi|251812995, gi... - gi|251812995|ref|ZP_04827468.1| copper-transporting ATPase copA [Staphylococcus aureus subsp. aureus...
682.0 [0..2] [833..4]

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Predicted Domain #1
Region A:
Residues: [1-181]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQTIDLTLD GLSCGHCVKR VKESLEQRPD VEQADVSITE AHVTGTASAE QLIETIKQAG  60
   61 YDASVSHPKA KPLAESSIPS EALTAVSEAL PAATADDDDS QQLLLSGMSC ASCVTRVQNA 120
  121 LQSVPGVTQA RVNLAERTAL VMGSASPQDL VQAVEKAGYG AEAIEDDAKR RERQQETAVA 180
  181 T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.154902
Match: 1p6tA
Description: Structure characterization of the water soluble region of P-type ATPase CopA from Bacillus subtilis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
copper chaperone activity 9.82063669832995 bayes_pls_golite062009
copper-dependent protein binding 9.4886676850819 bayes_pls_golite062009
metallochaperone activity 8.74818422646376 bayes_pls_golite062009
superoxide dismutase copper chaperone activity 7.67724993505658 bayes_pls_golite062009
copper ion transmembrane transporter activity 6.91184156399207 bayes_pls_golite062009
copper ion binding 5.41725082570189 bayes_pls_golite062009
metal ion transmembrane transporter activity 5.4007166857771 bayes_pls_golite062009
copper-exporting ATPase activity 5.04749761961029 bayes_pls_golite062009
copper-transporting ATPase activity 5.03252922496602 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 4.79570221435856 bayes_pls_golite062009
cation transmembrane transporter activity 4.61622753861072 bayes_pls_golite062009
ion transmembrane transporter activity 4.52484959112186 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.12792340516867 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 4.10264569844449 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 3.70964017127302 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 3.27250923701445 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 2.98847682261773 bayes_pls_golite062009
metal ion binding 2.69806984896689 bayes_pls_golite062009
cation binding 2.69806984896689 bayes_pls_golite062009
ion binding 2.69078950610234 bayes_pls_golite062009
transition metal ion binding 2.52520930681159 bayes_pls_golite062009
transporter activity 2.43435890488191 bayes_pls_golite062009
transmembrane transporter activity 2.32163502360862 bayes_pls_golite062009
binding 2.31155280022787 bayes_pls_golite062009
substrate-specific transporter activity 2.28845421748925 bayes_pls_golite062009
primary active transmembrane transporter activity 1.62116507842838 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 1.61680623728503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 1.59572740343301 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 1.5925429451548 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 1.59219836319916 bayes_pls_golite062009
active transmembrane transporter activity 1.53883152283038 bayes_pls_golite062009
hydrolase activity 1.26149508477113 bayes_pls_golite062009
ATPase activity 1.12732384636594 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.1123150216263 bayes_pls_golite062009
pyrophosphatase activity 1.04872000948037 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.03270166246194 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.02977205960797 bayes_pls_golite062009
ATPase activity, coupled 1.02520458852568 bayes_pls_golite062009
protein binding 0.889287086236279 bayes_pls_golite062009
cation-transporting ATPase activity 0.75722873989123 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [182-252]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRFRWQAIV ALAVGIPVMV WGMIGDNMMV TADNRSLWLV IGLITLAVMV FAGGHFYRSA  60
   61 WKSLLNGAAT M

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [253-834]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTLVALGTGV AWLYSMSVNL WPQWFPMEAR HLYYEASAMI IGLINLGHML EARARQRSSK  60
   61 ALEKLLDLTP PTARLVTDEG EKSVPLAEVQ PGMLLRLTTG DRVPVDGEIT QGEAWLDEAM 120
  121 LTGEPIPQQK GEGDSVHAGT VVQDGSVLFR ASAVGSHTTL SRIIRMVRQA QSSKPEIGQL 180
  181 ADKISAVFVP VVVVIALVSA AIWYFFGPAP QIVYTLVIAT TVLIIACPCA LGLATPMSII 240
  241 SGVGRAAEFG VLVRDADALQ RASTLDTVVF DKTGTLTEGK PQVVAVKTFA DVDEAQALRL 300
  301 AAALEQGSSH PLARAILDKA GDMQLPQVNG FRTLRGLGVS GEAEGHALLL GNQALLNEQQ 360
  361 VGTKAIEAEI TAQASQGATP VLLAVDGKAV ALLAVRDPLR SDSVAALQRL HKAGYRLVML 420
  421 TGDNPTTANA IAKEAGIDEV IAGVLPDGKA EAIKHLQSEG RQVAMVGDGI NDAPALAQAD 480
  481 VGIAMGGGSD VAIETAAITL MRHSLMGVAD ALAISRATLH NMKQNLLGAF IYNSIGIPVA 540
  541 AGILWPFTGT LLNPVVAGAA MALSSITVVS NANRLLRFKP KE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 96.154902
Match: 1mhsA
Description: Proton ATPase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle