YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: clp-1
Organism: Caenorhabditis elegans
Length: 780 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for clp-1.

Description E-value Query
Range
Subject
Range
gi|49900979 - gi|49900979|gb|AAH75862.1| CAPN1 protein [Homo sapiens]
589.0 [0..312] [780..56]

Back

Predicted Domain #1
Region A:
Residues: [1-254]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADDEEEIIQ KVEVKPDEFN GLIGSIAGNL IRDKVGGAGG DILGGLASNF FGGGGGGGGG  60
   61 GGGGGFGGGN GGFGGGSNYD QGGNGNSGDQ QKRKRDMAKD LIGGIFDNVV NRKGKKEQDN 120
  121 YGGGGNYGGG GGNQGGGGGG GFNFNDIGGL INSMGGGGGG GQRQGGGGGG FGDILGGIGS 180
  181 LIGGGGGGQY NGGGGNVNPN NLNGGMVNVI GNLIGEAAHR FLGVDPGTGR IIGAVAGNVI 240
  241 MGLGGKDNSL GNIG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.39794
Match: 2quaA
Description: No description for 2quaA was found.

Predicted Domain #2
Region A:
Residues: [255-320]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVILDNIISG KFRRDVDPFV RPGPDPDRGG GGSGPSPISP RPTTEPQDFY ELRDQCLESK  60
   61 RLFEDP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [321-780]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QFLANDSSLF FSKRPPKRVE WLRPGEITRE PQLITEGHSR FDVIQGELGD CWLLAAAANL  60
   61 TLKDELFYRV VPPDQSFTEN YAGIFHFQFW QYGKWVDVVI DDRLPTSNGE LLYMHSASNN 120
  121 EFWSALLEKA YAKLFGSYEA LKGGTTSEAL EDMTGGLTEF IDLKNPPRNL MQMMMRGFEM 180
  181 GSLFGCSIEA DPNVWEAKMS NGLVKGHAYS ITGCRIVDGP NGQTCILRIR NPWGNEQEWN 240
  241 GPWSDNSREW RSVPDSVKQD MGLKFDHDGE FWMSFDDFMR NFEKMEICNL GPDVMDEVYQ 300
  301 MTGVKAAGMV WAANTHDGAW VRNQTAGGCR NYINTFANNP QFRVQLTDSD PDDDDELCTV 360
  361 IFAVLQKYRR NLKQDGLDNV PIGFAVYDAG NNRGRLSKQF FAANKSAMRS AAFINLREMT 420
  421 GRFRVPPGNY VVVPSTFEPN EEAEFMLRVY TNGFIESEEL 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 163.0
Match: 1kfuL
Description: Calpain large subunit, C-terminal domain (domain IV); Calpain large subunit, middle domain (domain III); Calpain large subunit, catalytic domain (domain II)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.19059336788201 bayes_pls_golite062009
cysteine-type peptidase activity 3.05412701733177 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.93596559605971 bayes_pls_golite062009
endopeptidase activity 2.91734319991078 bayes_pls_golite062009
hydrolase activity 2.43328552376748 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
protein binding 1.92445772322782 bayes_pls_golite062009
binding 1.92046698500094 bayes_pls_golite062009
transporter activity 1.21845572420504 bayes_pls_golite062009
cytoskeletal protein binding 1.19670958990587 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.07520173658976 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
transmembrane transporter activity 1.00091316610003 bayes_pls_golite062009
signal transducer activity 0.9347662946007 bayes_pls_golite062009
molecular transducer activity 0.9347662946007 bayes_pls_golite062009
calcium ion binding 0.687204894708051 bayes_pls_golite062009
ubiquitin-specific protease activity 0.495368836247989 bayes_pls_golite062009
substrate-specific transporter activity 0.484449686814032 bayes_pls_golite062009
transcription regulator activity 0.354062437867002 bayes_pls_golite062009
nucleic acid binding 0.313326619937245 bayes_pls_golite062009
DNA binding 0.306964954191276 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.246369226539662 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
active transmembrane transporter activity 0.193338880082314 bayes_pls_golite062009
tubulin binding 0.11107511867058 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle