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View Structure Prediction Details

Protein: unc-62
Organism: Caenorhabditis elegans
Length: 490 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-62.

Description E-value Query
Range
Subject
Range
unc-62 - homeobox protein status:Confirmed UniProt:Q9N5D6 protein_id:AAF39974.1
324.0 [0..1] [490..75]

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Predicted Domain #1
Region A:
Residues: [1-166]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGAPTSTPM MHHEMGEAMK RDKESIYAHP LYPLLVLLFE KCELATSTPR DTSRDGSTSS  60
   61 DVCSSASFKD DLNEFVRHTQ ENADKQYYVP NPQLDQIMLQ SIQMLRFHLL ELEKVHELCD 120
  121 NFCNRYVVCL KGKMPLDIVG DERASSSQPP MSPGSMGHLG HSSSPS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [167-302]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGGATPMHY PPPYEPQSVP LPENAGVMGG HPMEGSSMAY SMAGMAAAAA SSSSSSNQAG  60
   61 DHPLANGGTL HSTAGASQTL LPIAVSSPST CSSGGLRQDS TPLSGETPMG HANGNSMDSI 120
  121 SEAGDEFSVC GSNDDG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [303-386]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDSVLSDSAN GSQNGKRKVP KVFSKEAITK FRAWLFHNLT HPYPSEEQKK QLAKETGLTI  60
   61 LQVNNWFINA RRRIVQPMID QNNR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.69897
Match: 1pufA
Description: Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 1.62959077995642 bayes_pls_golite062009
binding 1.48969201384255 bayes_pls_golite062009
DNA binding 1.2137926921894 bayes_pls_golite062009
nucleic acid binding 1.02805703044131 bayes_pls_golite062009
transcription factor activity 0.89626527070971 bayes_pls_golite062009
sequence-specific DNA binding 0.06790788268651 bayes_pls_golite062009
protein binding 0.012115247005138 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [387-490]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGRSGQMNVC KNRRRNRSEQ SPGPSPDSGS DSGANYSPDP SSLAASTAMP YPAEFYMQRT  60
   61 MPYGGFPSFT NPAMPFMNPM MGFQVAPTVD ALSQQWVDLS APHE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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Created and Maintained by: Michael Riffle