YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30254298, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	609 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30254298, gi|....

Description	E-value	Query Range	Subject Range
gi\|42779846, gi\|... - gi\|42779846\|ref\|NP_977093.1\| sodium/hydrogen exchanger family protein [Bacillus cereus ATCC 10987], ...	1.0E-68	[1..609]	[1..609]
gi\|30018876, gi\|... - gi\|30018876\|ref\|NP_830507.1\| Na+/H+ antiporter NapA [Bacillus cereus ATCC 14579], gi\|29894418\|gb\|AAP... gi\|228657332, gi... - gi\|229126125\|ref\|ZP_04255146.1\| Na+/H+ antiporter [Bacillus cereus BDRD-Cer4], gi\|228657332\|gb\|EEL13...	2.0E-68	[1..609]	[7..615]
gi\|47554505, gi\|... - gi\|47568829\|ref\|ZP_00239523.1\| Na+/H+ antiporter, putative [Bacillus cereus G9241], gi\|47554505\|gb\|E...	3.0E-68	[1..609]	[1..609]
gi\|89203017, gi\|... - gi\|89203017\|ref\|ZP_01181718.1\| TrkA-N:TrkA-C:Sodium/hydrogen exchanger [Bacillus cereus subsp. cytot...	4.0E-68	[1..609]	[1..609]
gi\|75762632, gi\|... - gi\|75762632\|ref\|ZP_00742477.1\| Na+/H+ antiporter napA [Bacillus thuringiensis serovar israelensis AT...	5.0E-68	[1..609]	[36..644]
gi\|163938623, gi... - gi\|89207986\|ref\|ZP_01186512.1\| TrkA-N:TrkA-C:Sodium/hydrogen exchanger [Bacillus weihenstephanensis ...	5.0E-68	[1..609]	[1..609]
gi\|75909294, gi\|... - gi\|75909294\|ref\|YP_323590.1\| Sodium/hydrogen exchanger [Anabaena variabilis ATCC 29413], gi\|75703019...	1.0E-64	[6..609]	[7..665]
gi\|17229538, gi\|... - gi\|17229538\|ref\|NP_486086.1\| hypothetical protein alr2046 [Nostoc sp. PCC 7120], gi\|17131137\|dbj\|BAB... gi\|25534468 - pir\|\|AH2061 hypothetical protein alr2046 [imported] - Nostoc sp. (strain PCC 7120)	1.0E-64	[6..609]	[7..665]
gi\|186682968, gi... - gi\|23123962\|ref\|ZP_00105985.1\| COG0475: Kef-type K+ transport systems, membrane components [Nostoc p...	5.0E-64	[6..607]	[7..663]
gi\|68555006, gi\|... - gi\|94309253\|ref\|YP_582463.1\| sodium/hydrogen exchanger [Ralstonia metallidurans CH34], gi\|93353105\|g...	2.0E-62	[4..608]	[17..671]

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Predicted Domain #1

Region A:
Residues: [1-196]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEHHTSVLSL MVVVAIAFFV PLLLQRFKLK ALPVVVAEII AGIFVGKSGF NIIEPDMWLQ  60
   61 VLSTLGFIFL MFLSGLEIDF SIFKQKGKKN TTNEPNTFQA ASVIFLFIFI LSYALSLLFV 120
  121 WLGFVDNAMF MTLIISTISL GVVVPTLKEN NLGKTAIGQI ILLVAVIADL VTMILLAVFV 180
  181 GLNSESGQSM WLLLLL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [197-293]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGAGIVIYFV AKRFKNIPYL DSLKAGSVQI DTRAVFALIL ILVGLSESVG AENILGAFLA  60
   61 GVLVSLLSPN EDMVEKLDSI GYGFFIPIFF VMVGVNL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [294-609]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVWSIFKEPS SMLMIPILIV GLFISKLIPS LVLRKWYPRN IVLGSAILLT STLSLVIAAA  60
   61 QIGEKLGIIS PSLSASLILS AVITCIFAPI LFKKMFPKVE TPKPKVSIIG ASRITLPLSL 120
  121 DLKREDYDVT LYMMRQNKIN DEEAKSHDFP IVKLDDITIA SLTEQTAFHA DRVVVATSDD 180
  181 EQNLLLAEHA KELGVEHVIA SVEDPLLQEK ATQEHIAVFS TINSTRILLR ALIDKPSLVR 240
  241 LITTANETVR EVELRSNKYN GVALRRLPFL GDVLVIQIYR GNKALIPHGD TRLQHGDTLL 300
  301 VTGSKEHIDT LKSILE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.221849
Match:	1lnqA
Description:	Potassium channel-related protein MthK
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
voltage-gated potassium channel activity	6.21910668359976	bayes_pls_golite062009
potassium channel activity	6.16173403398462	bayes_pls_golite062009
metal ion transmembrane transporter activity	5.93188092092616	bayes_pls_golite062009
voltage-gated cation channel activity	5.77180396865088	bayes_pls_golite062009
voltage-gated ion channel activity	5.59799302047339	bayes_pls_golite062009
voltage-gated channel activity	5.57395404746816	bayes_pls_golite062009
cation channel activity	5.49362429102263	bayes_pls_golite062009
cation transmembrane transporter activity	5.13805155650973	bayes_pls_golite062009
ion transmembrane transporter activity	5.04374327766634	bayes_pls_golite062009
ion channel activity	4.88752793243149	bayes_pls_golite062009
gated channel activity	4.87650815860853	bayes_pls_golite062009
substrate-specific channel activity	4.76774891791883	bayes_pls_golite062009
channel activity	4.7460548761362	bayes_pls_golite062009
passive transmembrane transporter activity	4.7460548761362	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	4.64120459994573	bayes_pls_golite062009
inward rectifier potassium channel activity	4.10787296124574	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	3.88411419181428	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	2.96809690970616	bayes_pls_golite062009
ligand-gated ion channel activity	2.94075163359893	bayes_pls_golite062009
ligand-gated channel activity	2.94075163359893	bayes_pls_golite062009
transporter activity	2.93091397928047	bayes_pls_golite062009
transmembrane transporter activity	2.82224868778929	bayes_pls_golite062009
substrate-specific transporter activity	2.79688978937497	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.13014428099026	bayes_pls_golite062009
potassium ion transmembrane transporter activity	0.320891299670562	bayes_pls_golite062009
active transmembrane transporter activity	0.239024094835991	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: