YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30258882, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	333 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30258882, gi|....

Description	E-value	Query Range	Subject Range
gi\|85669109, gi\|... - gi\|85706336\|ref\|ZP_01037430.1\| pyruvate dehydrogenase complex, E1 component, alpha subunit [Roseovar...	8.0E-69	[10..333]	[8..330]
gi\|47553647, gi\|... - gi\|47569679\|ref\|ZP_00240354.1\| 2-oxoisovalerate dehydrogenase, E1 component, alpha subunit [Bacillus... gi\|42739208, gi\|... - gi\|42783280\|ref\|NP_980527.1\| 3-methyl-2-oxobutanoate dehydrogenase, alpha subunit [Bacillus cereus A...	1.0E-68	[1..333]	[1..333]
gi\|114704544, gi... - gi\|114704544\|ref\|ZP_01437452.1\| pyruvate dehydrogenase alpha2 subunit protein [Fulvimarina pelagi HT...	2.0E-68	[6..333]	[46..372]
gi\|35213414, gi\|... - gi\|37522413\|ref\|NP_925790.1\| pyruvate dehydrogenase E1 alpha-subunit [Gloeobacter violaceus PCC 7421...	2.0E-68	[10..333]	[8..329]
gi\|66267554, gi\|... - gi\|66267554\|gb\|AAH94760.1\| PDHA2 protein [Homo sapiens], gi\|34192185\|gb\|AAH30697.2\| PDHA2 protein [H...	3.0E-68	[4..332]	[63..387]
gi\|55622948 - gi\|55622948\|ref\|XP_526637.1\| PREDICTED: pyruvate dehydrogenase (lipoamide) alpha 2 [Pan troglodytes]	5.0E-68	[4..332]	[97..421]
gi\|53796599 - ref\|ZP_00357546.1\| COG1071: Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) compon... gi\|76261293, gi\|... - gi\|76261293\|ref\|ZP_00768908.1\| Dehydrogenase, E1 component [Chloroflexus aurantiacus J-10-fl], gi\|76... gi\|222527177, gi... - gi\|222527177\|ref\|YP_002571648.1\| Pyruvate dehydrogenase (acetyl-transferring) [Chloroflexus sp. Y-40...	5.0E-68	[12..333]	[1..320]
gi\|83954327, gi\|... - gi\|83954327\|ref\|ZP_00963047.1\| pyruvate dehydrogenase complex, E1 component, alpha subunit [Sulfitob...	9.0E-68	[6..332]	[4..329]
gi\|83406095, gi\|... - gi\|83406095\|gb\|AAI11210.1\| Pyruvate dehydrogenase (lipoamide) alpha 2 [Bos taurus], gi\|116004359\|ref...	1.0E-67	[1..332]	[44..371]

Back

Predicted Domain #1

Region A:
Residues: [1-333]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEVKEKRHE ELGLSDEQVL EMFRTMLLAR KIDERMWLLN RAGKIPFVIS CQGQEAAQVG  60
   61 AAFALDREKD YALPYYRDMG VVLAFGMTAK ELMLSGFAKA GDPNSGGRQM PGHFGQKKNR 120
  121 IVTGSSPVTT QVPHAVGIAL AGKMEKKDLV TFVTFGEGSS NQGDFHEGAN FAGVHKLPVI 180
  181 FMCENNKYAI SIPVEKQLAC KNVSDRAIGY GMPGYTVDGN DPLAVYKAVK EAADRGRRGE 240
  241 GPTLIETVSY RLTAHSSDDD DRVYRDKEEV EEAKKNDSIV TFAAYLKEVG VLTEESEKQM 300
  301 LDEIMHIVNE ATEYAENAPY AAPEDALKHV YAE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.69897
Match:	1um9A
Description:	branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8 in apo-form
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pyruvate dehydrogenase activity	11.3856674722026	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	11.0549577473177	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	10.8180381281695	bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	7.00951713446616	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	4.89064211833637	bayes_pls_golite062009
acetolactate synthase activity	4.51986503762195	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	3.8269109174531	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	2.61614462349133	bayes_pls_golite062009
catalytic activity	2.25537597692103	bayes_pls_golite062009
oxidoreductase activity	1.85833680148029	bayes_pls_golite062009
transketolase activity	1.53492491341322	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	0.667418924427388	bayes_pls_golite062009
pyruvate decarboxylase activity	0.198062360371269	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: