YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|33238768, gi\|...
Organism:	Prochlorococcus marinus subsp. marinus str. CCMP1375
Length:	400 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|33238768, gi|....

Description	E-value	Query Range	Subject Range
gi\|22298621, gi\|... - gi\|22298621\|ref\|NP_681868.1\| adenine glycosylase [Thermosynechococcus elongatus BP-1], gi\|22294801\|d...	258.0	[0..23]	[390..15]
gi\|84519058, gi\|... - gi\|84519058\|ref\|ZP_01006407.1\| A/G-specific DNA glycosylase [Prochlorococcus marinus str. MIT 9211],...	250.0	[0..6]	[392..6]
gi\|53762849, gi\|... - gi\|81299484\|ref\|YP_399692.1\| A/G-specific DNA-adenine glycosylase [Synechococcus elongatus PCC 7942]... gi\|56750865, gi\|... - gi\|56750865\|ref\|YP_171566.1\| mutator MutT protein [Synechococcus elongatus PCC 6301], gi\|56685824\|db...	250.0	[0..15]	[389..1]
gi\|72002893, gi\|... - gi\|72383043\|ref\|YP_292398.1\| A/G-specific DNA-adenine glycosylase [Prochlorococcus marinus str. NATL...	241.0	[0..21]	[397..7]
gi\|86608236, gi\|... - gi\|86608236\|ref\|YP_476998.1\| A/G-specific adenine glycosylase [Synechococcus sp. JA-2-3B'a(2-13)], g... gi\|86608236 - gi\|86608236\|ref\|YP_476998.1\| A/G-specific adenine glycosylase [Cyanobacteria bacterium Yellowstone B...	238.0	[0..24]	[392..1]
gi\|33864651, gi\|... - gi\|33864651\|ref\|NP_896210.1\| putative adenine glycosylase [Synechococcus sp. WH 8102], gi\|33632174\|e...	237.0	[0..23]	[389..18]
gi\|83757907, gi\|... - gi\|83816513\|ref\|YP_446225.1\| A/G-specific adenine glycosylase [Salinibacter ruber DSM 13855], gi\|837...	234.0	[0..28]	[390..1]
gi\|86605515, gi\|... - gi\|86605515\|ref\|YP_474278.1\| A/G-specific adenine glycosylase [Synechococcus sp. JA-3-3Ab], gi\|86554... gi\|86605515 - gi\|86605515\|ref\|YP_474278.1\| A/G-specific adenine glycosylase [Cyanobacteria bacterium Yellowstone A...	228.0	[0..21]	[394..1]
gi\|78211651, gi\|... - gi\|78211651\|ref\|YP_380430.1\| A/G-specific DNA-adenine glycosylase [Synechococcus sp. CC9605], gi\|781...	226.0	[0..23]	[391..29]
gi\|78168021, gi\|... - gi\|78183727\|ref\|YP_376161.1\| Mutator MutT [Synechococcus sp. CC9902], gi\|78168021\|gb\|ABB25118.1\| A/G...	225.0	[0..47]	[398..3]

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Predicted Domain #1

Region A:
Residues: [1-400]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGFRVSQDNY ALEVFESMNQ IEDMRSSLLN WFKLNGRHWI PWKVKSDGNV PKIQEKLPVY  60
   61 PIWVAEVMLQ QTQLKVVLPY WEKWMRTFPI LPDFAHALDH EVLLLWQGLG YYSRAHRMHQ 120
  121 ASKKLLDIIG HADSLDPDSW PSDIDSWIAL PGIGRNTAAS IISSAFNVPA SLLDGNVKRI 180
  181 LARLIGSKKI LSKDSARLWK LSDLLLDNHE PRNFNQALMD LGSTVCTIKS PKCCCCPWKK 240
  241 YCLAYHQGNP TEFPIKGPKK LLPDFVIGIG LIFNDLGEIL IAQRKSNQSM GGMWEFPGGK 300
  301 QEEGESIEYT IIRELQEELG IKVRVGNILL EFDHSYTHKK LHFVVYFCEL ISGVPKPLAS 360
  361 LQLKWVKSHE LVNYPFPAAN KKMISALKKY LLLSKDSEAL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.0
Match:	1rrqA
Description:	MutY adenine glycosylase in complex with DNA containing an A:oxoG pair
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA-(apurinic or apyrimidinic site) lyase activity	3.71152530486175	bayes_pls_golite062009
MutLbeta complex binding	3.54991362477413	bayes_pls_golite062009
MutSbeta complex binding	3.54991362477413	bayes_pls_golite062009
oxidized base lesion DNA N-glycosylase activity	2.49872706126491	bayes_pls_golite062009
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	2.21048599823382	bayes_pls_golite062009
damaged DNA binding	2.00388798014411	bayes_pls_golite062009
hydrolase activity	1.97832429767892	bayes_pls_golite062009
DNA binding	1.70910448624199	bayes_pls_golite062009
alkylbase DNA N-glycosylase activity	1.5832578018127	bayes_pls_golite062009
catalytic activity	1.49075808737475	bayes_pls_golite062009
oxidized purine base lesion DNA N-glycosylase activity	1.32985950765371	bayes_pls_golite062009
oxidized pyrimidine base lesion DNA N-glycosylase activity	1.2016453685638	bayes_pls_golite062009
nucleic acid binding	1.06392208444166	bayes_pls_golite062009
DNA-3-methyladenine glycosylase I activity	1.06383943982125	bayes_pls_golite062009
transcription regulator activity	0.953912155797942	bayes_pls_golite062009
uracil DNA N-glycosylase activity	0.879508131574476	bayes_pls_golite062009
structure-specific DNA binding	0.85419760398899	bayes_pls_golite062009
binding	0.804982034963737	bayes_pls_golite062009
purine-specific mismatch base pair DNA N-glycosylase activity	0.68578837518217	bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity	0.661651574677137	bayes_pls_golite062009
double-stranded DNA binding	0.57099109384393	bayes_pls_golite062009
pyrophosphatase activity	0.546676461152337	bayes_pls_golite062009
transcription factor activity	0.181268475863531	bayes_pls_golite062009
carbon-oxygen lyase activity	0.0676784802238829	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.00783582682768413	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: