YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30257197, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	481 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30257197, gi|....

Description	E-value	Query Range	Subject Range
gi\|49329327, gi\|... - gi\|49477771\|ref\|YP_036679.1\| penicillin-binding protein [Bacillus thuringiensis serovar konkukian st...	0.0	[1..481]	[1..481]
gi\|52142924, gi\|... - gi\|52142924\|ref\|YP_083905.1\| penicillin-binding protein [Bacillus cereus E33L], gi\|51976393\|gb\|AAU17...	0.0	[1..481]	[1..481]
gi\|190563450, gi... - gi\|190565423\|ref\|ZP_03018343.1\| putative penicillin-binding protein [Bacillus anthracis Tsiankovskii... gi\|170130361, gi... - gi\|170704560\|ref\|ZP_02895026.1\| putative penicillin-binding protein [Bacillus anthracis str. A0389],... gi\|172084241, gi... - gi\|177649167\|ref\|ZP_02932169.1\| putative penicillin-binding protein [Bacillus anthracis str. A0174],... gi\|229268036, gi... - gi\|229603628\|ref\|YP_002866887.1\| putative penicillin-binding protein [Bacillus anthracis str. A0248]... gi\|167637834, gi... - gi\|167637834\|ref\|ZP_02396113.1\| putative penicillin-binding protein [Bacillus anthracis str. A0193],... gi\|65319878 - gi\|65319878\|ref\|ZP_00392837.1\| COG1680: Beta-lactamase class C and other penicillin binding proteins... gi\|170670515, gi... - gi\|170685155\|ref\|ZP_02876379.1\| putative penicillin-binding protein [Bacillus anthracis str. A0465],... gi\|165869032, gi... - gi\|165869032\|ref\|ZP_02213692.1\| putative penicillin-binding protein [Bacillus anthracis str. A0488],... gi\|167632641, gi... - gi\|167632641\|ref\|ZP_02390968.1\| putative penicillin-binding protein [Bacillus anthracis str. A0442],...	0.0	[20..481]	[2..463]
gi\|42781640, gi\|... - gi\|42781640\|ref\|NP_978887.1\| penicillin-binding protein, putative [Bacillus cereus ATCC 10987], gi\|4...	0.0	[1..481]	[1..481]
gi\|25489448 - pir\|\|C83739 hypothetical protein BH0715 [imported] - Bacillus halodurans (strain C-125) gi\|15613278, gi\|... - gi\|15613278\|ref\|NP_241581.1\| hypothetical protein BH0715 [Bacillus halodurans C-125], gi\|10173329\|db...	0.0	[23..480]	[20..477]
gi\|89207507, gi\|... - gi\|89207507\|ref\|ZP_01186047.1\| Beta-lactamase [Bacillus weihenstephanensis KBAB4], gi\|89154568\|gb\|EA...	1.0E-97	[1..481]	[1..481]
gi\|251811870, gi... - gi\|251811870\|ref\|ZP_04826343.1\| beta-lactamase [Staphylococcus epidermidis BCM-HMP0060], gi\|25180466... gi\|27316473, gi\|... - gi\|27468925\|ref\|NP_765562.1\| beta-lactamase [Staphylococcus epidermidis ATCC 12228], gi\|27316473\|gb\|...	6.0E-92	[1..472]	[1..488]
gi\|57636040, gi\|... - gi\|57865382\|ref\|YP_189575.1\| fmtA-like protein [Staphylococcus epidermidis RP62A], gi\|57636040\|gb\|AA...	4.0E-91	[1..472]	[1..488]
gi\|90427028, gi\|... - gi\|90583887\|ref\|ZP_01239636.1\| Beta-lactamase [Staphylococcus aureus subsp. aureus JH1], gi\|90427028... FLP_STAAM - Protein flp OS=Staphylococcus aureus (strain Mu50 / ATCC 700699) GN=flp PE=3 SV=1 FLP_STAAN - Protein flp OS=Staphylococcus aureus (strain N315) GN=flp PE=1 SV=1 gi\|255007216 - gi\|255007216\|ref\|ZP_05145817.2\| hypothetical protein SauraM_12125 [Staphylococcus aureus subsp. aure... gi\|253314777 - gi\|253314777\|ref\|ZP_04837990.1\| hypothetical protein SauraC_01120 [Staphylococcus aureus subsp. aure... gi\|25506359 - pir\|\|B99946 hypothetical protein SA2230 [imported] - Staphylococcus aureus (strain N315) gi\|148268878, gi... - gi\|148268878\|ref\|YP_001247821.1\| beta-lactamase [Staphylococcus aureus subsp. aureus JH9], gi\|147741... gi\|156722891, gi... - gi\|156980756\|ref\|YP_001443015.1\| hypothetical protein SAHV_2425 [Staphylococcus aureus subsp. aureus... gi\|269204074\|ref... - fmtA-like protein [Staphylococcus aureus subsp. aureus ED98]	6.0E-88	[4..478]	[10..484]
gi\|251813117, gi... - gi\|251813117\|ref\|ZP_04827590.1\| beta-lactamase [Staphylococcus aureus subsp. aureus TCH70], gi\|25180... FLP_STAAS - Protein flp OS=Staphylococcus aureus (strain MSSA476) GN=flp PE=3 SV=1	7.0E-88	[4..478]	[10..484]

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Predicted Domain #1

Region A:
Residues: [1-381]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNAIYKVFL ICILCNVFML CITHPKVYAQ QNVKVTLDKY IEKFIKEQNI PGAAVAIVHN  60
   61 KEVFFTKTMG VTGESEKKVT SKTPFAIGSI SKSLTALAIV KLIEDKKIKL EDPVQRYLPW 120
  121 FKLKNPQISS TITIQHLLTH TSGINTYEGL ALSDKQSKSS TALKENVMKL SNVKVTAPPG 180
  181 EKYQYSNANY IVLGALIEEV TNETYSSYME KYIFQPLNMN GAAASKENAY EKGYLTGYQS 240
  241 WFGIPRKSVV SYDNTGAPYG YITANLEDMI QYIMFLNRPE DAQLLKQENI HLYLSPLYKI 300
  301 NSEKSYGFGL RTTNINESET MIWHSGSTPD ARAELFTLNE SGWSGVILTN KNHVLEETAL 360
  361 SVLKKGIISI LNGEEPVDIP K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.69897
Match:	1rgyA
Description:	Citrobacter freundii GN346 Class C beta-Lactamase Complexed with Transition-State Analog of Cefotaxime
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
beta-lactamase activity	6.11754430606414	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	4.78031291375234	bayes_pls_golite062009
serine-type D-Ala-D-Ala carboxypeptidase activity	3.37745387761459	bayes_pls_golite062009
penicillin binding	3.16077730467133	bayes_pls_golite062009
serine-type carboxypeptidase activity	3.02516915958448	bayes_pls_golite062009
serine-type exopeptidase activity	2.98959517344587	bayes_pls_golite062009
carboxypeptidase activity	2.34154596924818	bayes_pls_golite062009
catalytic activity	2.2253600206851	bayes_pls_golite062009
drug binding	2.00354593744547	bayes_pls_golite062009
hydrolase activity	1.60399436620363	bayes_pls_golite062009
peptidase activity	1.19806036181576	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.93520664618869	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.9301046317358	bayes_pls_golite062009
serine hydrolase activity	0.7685205097747	bayes_pls_golite062009
serine-type peptidase activity	0.76747998716775	bayes_pls_golite062009
exopeptidase activity	0.373099549833319	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [382-481]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIPLTQIILL VVTLILFIIS IMLIKKYKHM KTVKKVIWLF IGSLSLLLSI IFIPLFTYST  60
   61 SSPWRTIKIF APDVALFTSI SVTLLAVNGL ISIFIALRRK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: