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View Structure Prediction Details

Protein: HGNC:9210|MIM:17...
Organism: SPECIES UNKNOWN
Length: 291 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HGNC:9210|MIM:17....

Description E-value Query
Range
Subject
Range
gi|114588000 - gi|114588000|ref|XP_526244.2| PREDICTED: POU domain, class 1, transcription factor 1 (Pit1, growth h...
4.0E-49 [1..291] [1..291]
gi|307335, gi|311926 - gi|311926|emb|CAA51017.1| transcription factor [Homo sapiens], gi|307335|gb|AAA60093.1| Pit-1/GHF-1 ...
4.0E-49 [1..291] [1..291]
PIT1_MACMU - Pituitary-specific positive transcription factor 1 OS=Macaca mulatta GN=POU1F1 PE=2 SV=2
1.0E-48 [1..291] [1..291]
gi|55741453 - ref|NP_001006950.1| POU domain, class 1, transcription factor 1 [Canis familiaris]
PIT1_CANLF - Pituitary-specific positive transcription factor 1 OS=Canis lupus familiaris GN=POU1F1 PE=2 SV=1
4.0E-48 [1..291] [1..291]
gi|47523414, gi|... - gi|6638252|gb|AAB65789.2| POU-domain transcriptional regulator [Sus scrofa], gi|47523414|ref|NP_9993...
7.0E-48 [1..291] [1..291]
PIT1_BOVIN - Pituitary-specific positive transcription factor 1 OS=Bos taurus GN=POU1F1 PE=2 SV=1
9.0E-48 [1..291] [1..291]
PIT1_SHEEP - Pituitary-specific positive transcription factor 1 OS=Ovis aries GN=POU1F1 PE=2 SV=1
2.0E-47 [1..291] [1..291]

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Predicted Domain #1
Region A:
Residues: [1-137]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSCQAFTSAD TFIPLNSDAS ATLPLIMHHS AAECLPVSNH ATNVMSTATG LHYSVPSCHY  60
   61 GNQPSTYGVM AGSLTPCLYK FPDHTLSHGF PPIHQPLLAE DPTAADFKQE LRRKSKLVEE 120
  121 PIDMDSPEIR ELEKFAN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [138-291]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFKVRRIKLG YTQTNVGEAL AAVHGSEFSQ TTICRFENLQ LSFKNACKLK AILSKWLEEA  60
   61 EQVGALYNEK VGANERKRKR RTTISIAAKD ALERHFGEQN KPSSQEIMRM AEELNLEKEV 120
  121 VRVWFCNRRQ REKRVKTSLN QSLFSISKEH LECR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.39794
Match: 1au7A
Description: Pit-1 POU homeodomain; Pit-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 5.51228466689923 bayes_pls_golite062009
nucleic acid binding 5.37468811865033 bayes_pls_golite062009
transcription regulator activity 5.05236457497789 bayes_pls_golite062009
transcription factor activity 3.89464979825638 bayes_pls_golite062009
binding 3.66501723413351 bayes_pls_golite062009
sequence-specific DNA binding 3.25218945600666 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22754992035091 bayes_pls_golite062009
transcription activator activity 3.15886611325686 bayes_pls_golite062009
transcription repressor activity 1.75958281319075 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
protein binding 1.55649304400241 bayes_pls_golite062009
chromatin binding 1.2739759748489 bayes_pls_golite062009
transcription factor binding 1.02788976342343 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.92393807212912 bayes_pls_golite062009
transcription cofactor activity 0.8718993114781 bayes_pls_golite062009
transcription coactivator activity 0.81316180547536 bayes_pls_golite062009
promoter binding 0.22765608166458 bayes_pls_golite062009
catalytic activity 0.00446472034106909 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle