YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|24372020, gi\|...
Organism:	Shewanella oneidensis MR-1
Length:	677 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24372020, gi|....

Description	E-value	Query Range	Subject Range
gi\|160877157, gi... - gi\|160877157\|ref\|YP_001556473.1\| pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase [...	490.0	[0..1]	[677..1]
gi\|68519158, gi\|... - gi\|68543114\|ref\|ZP_00582829.1\| Dihydrolipoamide acetyltransferase [Shewanella baltica OS155], gi\|685...	490.0	[0..1]	[677..1]
gi\|88772180, gi\|... - gi\|88796489\|ref\|ZP_01112157.1\| pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyl...	482.0	[0..1]	[677..1]
gi\|113968773, gi... - gi\|82497172\|ref\|ZP_00882730.1\| Dihydrolipoamide acetyltransferase [Shewanella sp. MR-4], gi\|82404761...	482.0	[0..1]	[677..1]
gi\|117918884, gi... - gi\|78688057\|ref\|ZP_00852782.1\| Dihydrolipoamide acetyltransferase [Shewanella sp. ANA-3], gi\|7850420...	481.0	[0..1]	[677..1]
gi\|114049085, gi... - gi\|78690758\|ref\|ZP_00855397.1\| Dihydrolipoamide acetyltransferase [Shewanella sp. MR-7], gi\|78509814...	481.0	[0..1]	[677..1]
gi\|76874269, gi\|... - gi\|77359358\|ref\|YP_338933.1\| pyruvate dehydrogenase dihydrolipoyltransacetylase subunit [Pseudoalter...	480.0	[0..1]	[677..1]
gi\|120557451, gi... - gi\|82742202\|ref\|ZP_00904902.1\| Dihydrolipoamide acetyltransferase [Shewanella sp. W3-18-1], gi\|82720... gi\|145566191, gi... - gi\|77813920\|ref\|ZP_00813191.1\| Dihydrolipoamide acetyltransferase [Shewanella putrefaciens CN-32], g...	477.0	[0..1]	[677..1]
gi\|114564928, gi... - gi\|114564928\|ref\|YP_752442.1\| pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase [She...	474.0	[0..1]	[677..1]
gi\|90438550, gi\|... - gi\|90580248\|ref\|ZP_01236055.1\| dihydrolipoamide acetyltransferase [Vibrio angustum S14], gi\|90438550...	472.0	[0..5]	[677..3]

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Predicted Domain #1

Region A:
Residues: [1-92]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAELKEVFVP DIGGDEVQVI EICAAVGDTL AAEESILTVE SDKATMDIPA PFAGVLAELK  60
   61 VAVGDKVSEG TLIALIQAAG ASAQAAAPVA QA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.69897
Match:	1qjoA
Description:	Ipoyl domain of dihydrolipoamide acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydrolipoyllysine-residue acetyltransferase activity	7.74877411346968	bayes_pls_golite062009
S-acetyltransferase activity	7.59642806209362	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	7.45508609960612	bayes_pls_golite062009
pyruvate dehydrogenase activity	7.05950875585975	bayes_pls_golite062009
S-acyltransferase activity	5.24395351180663	bayes_pls_golite062009
acetyltransferase activity	3.55333192628786	bayes_pls_golite062009
acetyl-CoA carboxylase activity	3.31123635155865	bayes_pls_golite062009
CoA carboxylase activity	2.82233689048595	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	2.53708026587542	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.22092493760605	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	1.71180073191487	bayes_pls_golite062009
acyltransferase activity	1.67824287219851	bayes_pls_golite062009
catalytic activity	1.39099902011318	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.629490807878017	bayes_pls_golite062009
ligase activity	0.56894584941056	bayes_pls_golite062009
aminomethyltransferase activity	0.377624262164477	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	0.0222922933292004	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	0.0222922933292004	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [93-235]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAPAPAPVQA APAPVVAAPA TGATKLVEAK VVEISVPDIG GDTDVSVIEV LVAAGDKIEV  60
   61 DAGLITLETD KATMDVPSPF AGVVKEVKVA VGDKVSQGSL VIMLEVGGAA PAAAPQANAP 120
  121 AASAPVAQAA PAAAVAPVAA VPV

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	4.57
Match:	1zy8K
Description:	The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [236-312]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAVKEIQVPD IGDASNVDVI EVLVSVGDMI SADQGLITLE TDKATMEVPA PFAGKLLSLT  60
   61 VKVGDKVSQG SVIATIE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	12.69897
Match:	1o78A
Description:	Biotin carboxyl carrier domain of transcarboxylase (TC 1.3S)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydrolipoyllysine-residue acetyltransferase activity	7.74877411346968	bayes_pls_golite062009
S-acetyltransferase activity	7.59642806209362	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	7.45508609960612	bayes_pls_golite062009
pyruvate dehydrogenase activity	7.05950875585975	bayes_pls_golite062009
S-acyltransferase activity	5.24395351180663	bayes_pls_golite062009
acetyltransferase activity	3.55333192628786	bayes_pls_golite062009
acetyl-CoA carboxylase activity	3.31123635155865	bayes_pls_golite062009
CoA carboxylase activity	2.82233689048595	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	2.53708026587542	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.22092493760605	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	1.71180073191487	bayes_pls_golite062009
acyltransferase activity	1.67824287219851	bayes_pls_golite062009
catalytic activity	1.39099902011318	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.629490807878017	bayes_pls_golite062009
ligase activity	0.56894584941056	bayes_pls_golite062009
aminomethyltransferase activity	0.377624262164477	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	0.0222922933292004	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	0.0222922933292004	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [313-437]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTSVATVSAG AATAPVAQAA APAPVAQEAA PAPVAAAPSR PPVPHHPSAG APVSTGAVHA  60
   61 SPAVRRLARE FGVDLTQVTG SGRKGRIMKE DVQAYVKYEL SRPKATAATS VATGNGGGLQ 120
  121 VIAAP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	21.522879
Match:	1zy8K
Description:	The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [438-677]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVDFSKFGEV EEIPLSRIQK ISGPNLHRNW VTIPHVTQFD EADITEMEEF RKQQNDAAAK  60
   61 KKADYKITPL VFMMKAVAKT LQQFPVFNSS LSSDGESLIQ KKYFHIGVAV DTPNGLVVPV 120
  121 VRDVDKKGII ELSRELADIS IRARDGKLKS ADMQGSCFTI SSLGGIGGTA FTPIVNYPDV 180
  181 AILGVSKSEI KPKWNGKEFE PKLMLPLSLS YDHRVIDGAM AARFSVTLSG ILSDIRTLIL 240
  241

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.39794
Match:	1dpcA
Description:	CRYSTALLOGRAPHIC AND ENZYMATIC INVESTIGATIONS ON THE ROLE OF SER558, HIS610 AND ASN614 IN THE CATALYTIC MECHANISM OF AZOTOBACTER VINELANDII DIHYDROLIPOAMIDE ACETYLTRANSFERASE (E2P)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydrolipoyllysine-residue acetyltransferase activity	9.65061123545754	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	9.64995677986911	bayes_pls_golite062009
S-acetyltransferase activity	9.49696044977584	bayes_pls_golite062009
S-acyltransferase activity	8.45313874919036	bayes_pls_golite062009
pyruvate dehydrogenase activity	8.17557182322815	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	6.40483178382327	bayes_pls_golite062009
acetyltransferase activity	6.08159176722072	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.93985773477717	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	5.74314131636952	bayes_pls_golite062009
acyltransferase activity	5.72047003788767	bayes_pls_golite062009
transferase activity, transferring acyl groups	4.60481199262496	bayes_pls_golite062009
S-succinyltransferase activity	4.47883105509359	bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity	4.47883105509359	bayes_pls_golite062009
carnitine O-acyltransferase activity	2.87366177129153	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.54513901872655	bayes_pls_golite062009
succinyltransferase activity	2.08404693277798	bayes_pls_golite062009
catalytic activity	1.51562638409295	bayes_pls_golite062009
O-acyltransferase activity	1.33852311685118	bayes_pls_golite062009
O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
carnitine O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
transferase activity	1.08341671157927	bayes_pls_golite062009
carnitine O-acetyltransferase activity	1.00868366840715	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	0.79135670574828	bayes_pls_golite062009
O-acetyltransferase activity	0.54660034926676	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions: