YRC Public Data Repository - Protein Structure Prediction

Protein:	WTM1_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	437 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for WTM1_YEAST.

Description	E-value	Query Range	Subject Range
gi\|17225208 - gi\|17225208\|gb\|AAL37300.1\|AF323584_1 beta transducin-like protein HET-E2C*40 [Podospora anserina]	0.0	[1..434]	[807..1251]
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=... gi\|25530855 - pir\|\|AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)	8.0E-93	[23..435]	[981..1443]
RBBP4 - retinoblastoma binding protein 4 RBBP4_MOUSE - Histone-binding protein RBBP4 OS=Mus musculus GN=Rbbp4 PE=1 SV=5 ENSCJAT00000001857 - null gi\|73949954, gi\|... - gi\|73949954\|ref\|XP_864445.1\| PREDICTED: similar to retinoblastoma binding protein 4 isoform 8 [Canis... gi\|123998073, gi... - gi\|60655333\|gb\|AAX32230.1\| retinoblastoma binding protein 4 [synthetic construct], gi\|60655331\|gb\|AA... ENSPTRT00000000953 - null RBBP4_BOVIN - Histone-binding protein RBBP4 OS=Bos taurus GN=RBBP4 PE=1 SV=3 gi\|157817007, gi... - gi\|197246471\|gb\|AAI68994.1\| Rbbp4 protein [Rattus norvegicus], gi\|157817007\|ref\|NP_001101382.1\| reti... gi\|449692 - gi\|449692\|prf\|\|1919423A retinoblastoma-binding protein tr\|M3WS50\|M3WS50... - RB binding protein 4, chromatin remodeling factor OS=Felis catus GN=RBBP4 PE=4 SV=1 gi\|126330240 - gi\|126330240\|ref\|XP_001366492.1\| PREDICTED: similar to retinoblastoma binding protein [Monodelphis d... gi\|109001615, gi... - gi\|109001618\|ref\|XP_001104493.1\| PREDICTED: retinoblastoma binding protein 4 isoform 7 [Macaca mulat...	7.0E-83	[4..431]	[22..404]
RBBP4_CHICK - Histone-binding protein RBBP4 OS=Gallus gallus GN=RBBP4 PE=1 SV=3	9.0E-83	[4..431]	[22..404]

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Predicted Domain #1

Region A:
Residues: [1-74]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKKVWKSST PSTYEHISSL RPKFVSRVDN VLHQRKSLTF SNVVVPDKKN NTLTSSVIYS  60
   61 QGSDIYEIDF AVPL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.859	0.004	transcription corepressor activity	b.3.2	Carboxypeptidase D, a regulatory domain

Predicted functions:

Term	Confidence	Notes
binding	2.42570478946173	bayes_pls_golite062009
transcription regulator activity	2.3610959773142	bayes_pls_golite062009
nucleic acid binding	2.30918780727915	bayes_pls_golite062009
protein binding	2.26925404328312	bayes_pls_golite062009
DNA binding	1.71685536470455	bayes_pls_golite062009
transcription activator activity	1.23969853550045	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.21305848427711	bayes_pls_golite062009
cytoskeletal protein binding	1.19593750149343	bayes_pls_golite062009
transcription factor activity	1.08768505897883	bayes_pls_golite062009
	0.88172763425403	bayes_pls_golite062009
transporter activity	0.692270256454453	bayes_pls_golite062009
histone binding	0.685319917508843	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.676924760416604	bayes_pls_golite062009
transcription repressor activity	0.658573452658359	bayes_pls_golite062009
DNA-dependent ATPase activity	0.612501046529002	bayes_pls_golite062009
actin binding	0.529861581509437	bayes_pls_golite062009
transcription factor binding	0.489473003915035	bayes_pls_golite062009
histone methyltransferase activity	0.311523647180993	bayes_pls_golite062009
transcription cofactor activity	0.30761651528651	bayes_pls_golite062009
structural molecule activity	0.254012051644049	bayes_pls_golite062009
protein kinase activity	0.229242350006544	bayes_pls_golite062009
transcription corepressor activity	0.182612389752591	bayes_pls_golite062009
chromatin binding	0.151977098745772	bayes_pls_golite062009
substrate-specific transporter activity	0.121183207943714	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.00585398682921312	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [75-437]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEAASEPVKD YGDAFEGIEN TSLSPKFVYQ GETVSKMAYL DKTGETTLLS MSKNGSLAWF  60
   61 KEGIKVPIHI VQELMGPATS YASIHSLTRP GDLPEKDFSL AISDFGISND TETIVKSQSN 120
  121 GDEEDSILKI IDNAGKPGEI LRTVHVPGTT VTHTVRFFDN HIFASCSDDN ILRFWDTRTS 180
  181 DKPIWVLGEP KNGKLTSFDC SQVSNNLFVT GFSTGIIKLW DARAAEAATT DLTYRQNGED 240
  241 PIQNEIANFY HAGGDSVVDV QFSATSSSEF FTVGGTGNIY HWNTDYSLSK YNPDDTIAPP 300
  301 QDATEESQTK SLRFLHKGGS RRSPKQIGRR NTAAWHPVIE NLVGTVDDDS LVSIYKPYTE 360
  361 ESE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	68.69897
Match:	1gg2B_
Description:	beta1-subunit of the signal-transducing G protein heterotrimer
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: