YRC Public Data Repository - Protein Structure Prediction

Protein:	SAS2_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	338 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SAS2_YEAST.

Description	E-value	Query Range	Subject Range
gi\|123979960, gi... - gi\|208966822\|dbj\|BAG73425.1\| MYST histone acetyltransferase 2 [synthetic construct], gi\|123994723\|gb... ENSPTRT00000017211 - null MYST2 - MYST histone acetyltransferase 2 gi\|149723942 - gi\|149723942\|ref\|XP_001502556.1\| PREDICTED: MYST histone acetyltransferase 2 isoform 1 [Equus caball...	0.0	[10..331]	[261..599]
gi\|7271813 - gi\|7271813\|gb\|AAF44628.1\| histone acetyltransferase [Drosophila melanogaster]	0.0	[3..335]	[445..797]
KAT8_MOUSE - Histone acetyltransferase KAT8 OS=Mus musculus GN=Kat8 PE=1 SV=1	0.0	[3..328]	[136..432]
SAS2 - Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acet... gi\|190408356 - gi\|190408356\|gb\|EDV11621.1\| histone acetyltransferase SAS2 [Saccharomyces cerevisiae RM11-1a] SAS2_YEAST - Histone acetyltransferase SAS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SAS2 PE=1...	0.0	[1..338]	[1..338]
gi\|162461408, gi... - gi\|194702096\|gb\|ACF85132.1\| unknown [Zea mays], gi\|17017390\|gb\|AAL33649.1\|AF440220_1 histone aceytl-...	0.0	[5..325]	[116..423]

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Predicted Domain #1

Region A:
Residues: [1-123]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARSLSQSLT ATTQKLKGKK NGGKGKNKPS AKIKKTQKEM LYGILNERNI RQIQFGLNKK  60
   61 FSTWYGSAVY FDPETKRLGC SETKGQLSSV SNSQYWLDTL FVCEYCFKYT DDQTRFVGHV 120
  121 ASC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	387.134302
Match:	1fy7A_
Description:	Histone acetyltransferase ESA1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
N-acetyltransferase activity	10.330867741687	bayes_pls_golite062009
histone acetyltransferase activity	10.2385402730839	bayes_pls_golite062009
lysine N-acetyltransferase activity	10.2385402730839	bayes_pls_golite062009
N-acyltransferase activity	10.2097972775096	bayes_pls_golite062009
acetyltransferase activity	9.5414870492393	bayes_pls_golite062009
acyltransferase activity	8.84144467104026	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	8.80032457938662	bayes_pls_golite062009
transferase activity, transferring acyl groups	8.58458341779614	bayes_pls_golite062009
	7.30820970670781	bayes_pls_golite062009
	5.06036596455843	bayes_pls_golite062009
transferase activity	2.87429355361226	bayes_pls_golite062009
transcription regulator activity	2.24760844790231	bayes_pls_golite062009
nucleic acid binding	2.13750665291344	bayes_pls_golite062009
catalytic activity	1.97933499002461	bayes_pls_golite062009
transcription repressor activity	1.31507488567214	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.30526320413082	bayes_pls_golite062009
binding	1.22537494136129	bayes_pls_golite062009
transcription coactivator activity	1.2180007740195	bayes_pls_golite062009
transcription factor binding	1.13174003342838	bayes_pls_golite062009
transcription activator activity	0.891911076312861	bayes_pls_golite062009
glycylpeptide N-tetradecanoyltransferase activity	0.774009286200155	bayes_pls_golite062009
myristoyltransferase activity	0.774009286200155	bayes_pls_golite062009
H3 histone acetyltransferase activity	0.710926740598251	bayes_pls_golite062009
histone binding	0.582104626133107	bayes_pls_golite062009
transcription cofactor activity	0.31196049232138	bayes_pls_golite062009
protein binding	0.075825416385311	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [124-236]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFQYRVPGKI KYKSPEYTIR RVKGSKYQLF CQCLCLFTKL YLDNKSMYFK VDHYEFYIVY  60
   61 ETGSTKPMGF FSKDLVSYQQ NNLACILIFP PYQRRGLGLL LIEFSYKLSQ LEG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	387.134302
Match:	1fy7A_
Description:	Histone acetyltransferase ESA1
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [237-338]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VISGPEVPLS PFGLIGYLKY WSQILCWHLI EGDLAHYDKV TLEDLSIVTG MRVNDVILTL  60
   61 KHLNCIGENN QIYLQSLNSW LKLHGTKRNW FKLKDEYLLI DD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	387.134302
Match:	1fy7A_
Description:	Histone acetyltransferase ESA1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: