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View Structure Prediction Details

Protein: WNK5_ARATH
Organism: Arabidopsis thaliana
Length: 549 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for WNK5_ARATH.

Description E-value Query
Range		 Subject
Range
gi|11358499, gi|... - gi|6580145|emb|CAB63149.1| MAP kinase [Arabidopsis thaliana], gi|20302602|dbj|BAB91128.1| Ser/Thr ki...
 408.0 [0..3] [549..1]

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Predicted Domain #1
Region A:
Residues: [1-297] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYMEISSASD DSIAYVETDP SGRYGRFREV LGKGAMKTVY KAFDQVLGME VAWNQVKLNE  60
   61 VFRSPEPLQR LYSEVHLLKN LNHESIIRYC TSWIDVNRRT FNFITELFTS GTLREYRRKY 120
  121 QKVDIRAIKS WARQILNGLA YLHGHDPPVI HRDLKCDNIF VNGHLGQVKI GDLGLAAILR 180
  181 GSQNAHSVIG TPEFMAPELY EEDYNELVDI YSFGMCVLEM LTGEYPYSEC TNPAQIYKKV 240
  241 TSGKLPDSFH LIQHTEAQRF VGKCLETVSR RLPAKELLAD PFLAATDERD LAPLFRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.69897
Match: 1t4hA
Description: Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein kinase activity 5.4586557943719 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 5.04467222534257 bayes_pls_golite062009
kinase activity 4.85903980916957 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.63692708178478 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.26787750561728 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.7769021678395 bayes_pls_golite062009
transmembrane receptor activity 1.6878868450299 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
receptor activity 1.57112777506542 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 1.4571078357189 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.02011129825141 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
cytoskeletal protein binding 0.748533008006377 bayes_pls_golite062009
MAP kinase kinase activity 0.610230065465794 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
insulin binding 0.326213234151689 bayes_pls_golite062009
kinase binding 0.26752427107238 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.26602283402868 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.26602283402868 bayes_pls_golite062009
growth factor binding 0.0526340287295695 bayes_pls_golite062009
tubulin binding 0.0510156114567444 bayes_pls_golite062009
PTB domain binding 0.0449060071013108 bayes_pls_golite062009
protein kinase binding 0.00674998152095019 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [298-412] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQQLAIQNLA ANGTVVEHLP STTDPTRTTD MSITGKMNSE DHTIFLQVQI LDGDGHMRNI  60
   61 QFPFNILSDT PLEVALEMVK ELEITDWDPL EIAAMIENEI SLLVPNWRAN DSSIR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.5
Match: 2v3sA
Description: No description for 2v3sA was found.

Predicted Domain #3
Region A:
Residues: [413-549] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HESFGHEDDE DNGDTEGRTR LFSSASSSHD SPVAVRENND DSSNDVIPDM DDGNRSSNRL  60
   61 LNSSTYHYSP AIDDDQNQQQ RRRVRLQQKM RSLVDTRTQV LHRSLMELIN KRRGRGFDPN 120
  121 TNELQPQPSS TDFIRRC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.522879
Match: 2v8qA
Description: No description for 2v8qA was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle