YRC Public Data Repository - Protein Structure Prediction

Protein:	ENSMMUT000000444...
Organism:	Macaca mulatta
Length:	484 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ENSMMUT000000444....

Description	E-value	Query Range	Subject Range
gi\|114583561 - gi\|114583561\|ref\|XP_001165390.1\| PREDICTED: paired box gene 3 isoform 6 [Pan troglodytes] gi\|31563344, gi\|... - gi\|31563344\|ref\|NP_852124.1\| paired box 3 isoform PAX3e [Homo sapiens], gi\|119591202\|gb\|EAW70796.1\| ...	2.0E-73	[1..484]	[1..484]
gi\|109477586, gi... - gi\|109477586\|ref\|XP_001071787.1\| PREDICTED: similar to paired box gene 7 [Rattus norvegicus], gi\|109...	9.0E-71	[1..484]	[1..476]
gi\|109101202 - gi\|109101202\|ref\|XP_001107628.1\| PREDICTED: paired box gene 3 (Waardenburg syndrome 1) isoform 7 [Ma...	3.0E-70	[1..484]	[1..484]
PAX7_MOUSE - Paired box protein Pax-7 OS=Mus musculus GN=Pax7 PE=1 SV=2 gi\|162319578, gi... - gi\|162319578\|gb\|AAI56885.1\| Paired box gene 7 [synthetic construct], gi\|162318458\|gb\|AAI56073.1\| Pai...	3.0E-70	[1..484]	[1..476]
gi\|114583573 - gi\|114583573\|ref\|XP_001165215.1\| PREDICTED: paired box gene 3 isoform 2 [Pan troglodytes]	3.0E-69	[1..484]	[1..481]

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Predicted Domain #1

Region A:
Residues: [1-200]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTLAGAVPR MMRPGPGQNY PRSGFPLEVS TPLGQGRVNQ LGGVFINGRP LPNHIRHKIV  60
   61 EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA IGGSKPKQVT TPDVEKKIEE 120
  121 YKRENPGMFS WEIRDKLLKD AVCDRNTVPS VSSISRILRS KFGKGEEEEA DLERKEAEES 180
  181 EKKAKHSIDG ILSERASAPQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	37.0
Match:	1k78A
Description:	Pax-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	5.13863038737912	bayes_pls_golite062009
DNA binding	4.66369707598026	bayes_pls_golite062009
nucleic acid binding	4.51452285155271	bayes_pls_golite062009
transcription factor activity	4.06706589695599	bayes_pls_golite062009
transcription repressor activity	3.55154985983449	bayes_pls_golite062009
sequence-specific DNA binding	3.5139760613123	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.16896789933192	bayes_pls_golite062009
transcription activator activity	3.10621734076555	bayes_pls_golite062009
binding	3.02779747447702	bayes_pls_golite062009
protein binding	1.88087411289001	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.73068440195944	bayes_pls_golite062009
chromatin binding	1.68956710349366	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.62096064323298	bayes_pls_golite062009
transcription corepressor activity	1.49423102874486	bayes_pls_golite062009
transcription factor binding	1.40653841901929	bayes_pls_golite062009
transcription cofactor activity	0.84983974758882	bayes_pls_golite062009
transcription coactivator activity	0.2679415219517	bayes_pls_golite062009
protein deacetylase activity	0.0943601066056998	bayes_pls_golite062009
histone deacetylase activity	0.0802156998596484	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [201-302]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDEGSDIDSE PDLPLKRKQR RSRTTFTAEQ LEELERAFER THYPDIYTRE ELAQRAKLTE  60
   61 ARVQVWFSNR RARWRKQAGA NQLMAFNHLI PGGFPPTAMP TL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	17.30103
Match:	1fjlA
Description:	Paired protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	5.13863038737912	bayes_pls_golite062009
DNA binding	4.66369707598026	bayes_pls_golite062009
nucleic acid binding	4.51452285155271	bayes_pls_golite062009
transcription factor activity	4.06706589695599	bayes_pls_golite062009
transcription repressor activity	3.55154985983449	bayes_pls_golite062009
sequence-specific DNA binding	3.5139760613123	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.16896789933192	bayes_pls_golite062009
transcription activator activity	3.10621734076555	bayes_pls_golite062009
binding	3.02779747447702	bayes_pls_golite062009
protein binding	1.88087411289001	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.73068440195944	bayes_pls_golite062009
chromatin binding	1.68956710349366	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.62096064323298	bayes_pls_golite062009
transcription corepressor activity	1.49423102874486	bayes_pls_golite062009
transcription factor binding	1.40653841901929	bayes_pls_golite062009
transcription cofactor activity	0.84983974758882	bayes_pls_golite062009
transcription coactivator activity	0.2679415219517	bayes_pls_golite062009
protein deacetylase activity	0.0943601066056998	bayes_pls_golite062009
histone deacetylase activity	0.0802156998596484	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [303-484]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTYQLSETSY QPTSIPQAVS DPSSTVHRPQ PLPPSTVHQS TIPSNPDSSS AYCLPSTRHG  60
   61 FSSYTDSFVP PSGPSNPMNP TIGNGLSPQV MGLLTNHGGV PHQPQTDYAL SPLTGGLEPT 120
  121 TTVSASCSQR LDHMKSLDSL PTSQSYCPPT YSTTGYSMDP VTGYQYGQYG QSAFHYLKPD 180
  181 IA

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: