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View Structure Prediction Details

Protein: gi|24079969
Organism: Homo sapiens
Length: 406 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24079969.

Description E-value Query
Range
Subject
Range
TFDP1 - transcription factor Dp-1
gi|123987073, gi... - gi|123999056|gb|ABM87113.1| transcription factor Dp-1 [synthetic construct], gi|123987073|gb|ABM8379...
0.0 [1..390] [5..394]
TFDP1_MOUSE - Transcription factor Dp-1 OS=Mus musculus GN=Tfdp1 PE=1 SV=1
0.0 [1..390] [5..394]
gi|73989562 - gi|73989562|ref|XP_849597.1| PREDICTED: similar to Transcription factor Dp-1 (E2F dimerization partn...
0.0 [1..390] [21..410]
TFDP1_BOVIN - Transcription factor Dp-1 OS=Bos taurus GN=TFDP1 PE=2 SV=1
0.0 [1..390] [5..394]
gi|50730508 - gi|50730508|ref|XP_416938.1| PREDICTED: similar to transcription factor [Gallus gallus]
0.0 [1..390] [5..395]
gi|114688131 - gi|114688131|ref|XP_521363.2| PREDICTED: similar to E2F-related transcription factor [Pan troglodyte...
0.0 [1..390] [5..393]
gi|52354615, gi|... - gi|52354615|gb|AAH82841.1| LOC494744 protein [Xenopus laevis], gi|148222844|ref|NP_001088050.1| hypo...
0.0 [1..389] [5..395]

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Predicted Domain #1
Region A:
Residues: [1-105]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGLIEANGEL KVFIDQNLSP GKGVVSLVAV HPSTVNPLGK QLLPKTFGQS NVNIAQQVVI  60
   61 GTPQRPAASN TLVVGSPHTP STHFASQNQP SDSSPWSAGK RNRKG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [106-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKNGKGLRHF SMKVCEKVQR KGTTSYNEVA DELVAEFSAA DNHILPNESA YDQKNIRRRV  60
   61 YDALNVLMAM NIISKEKKEI KWIGL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.69897
Match: 1cf7B
Description: Cell cycle transcription factor DP-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription activator activity 3.70589483230587 bayes_pls_golite062009
sequence-specific DNA binding 3.58179858678904 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
protein binding 1.80415286835431 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.2723726467408 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.23177057841536 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [191-406]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTNSAQECQN LEVERQRRLE RIKQKQSQLQ ELILQQIAFK NLVQRNRHAE QQASRPPPPN  60
   61 SVIHLPFIIV NTSKKTVIDC SISNDKFEYL FNFDNTFEIH DDIEVLKRMG MACGLESGSC 120
  121 SAEDLKMARS LVPKALEPYV TEMAQGTVGG VFITTAGSTS NGTRFSASDL TNGADGMLAT 180
  181 SSNGSQYSGS RVETPVSYVG EDDEEDDDFN ENDEDD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 70.154902
Match: 2azeA
Description: Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle