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View Structure Prediction Details

Protein: gi|24079969
Organism: Homo sapiens
Length: 406 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24079969.

Description E-value Query
Range
Subject
Range
TFDP1 - transcription factor Dp-1
gi|123987073, gi... - gi|123999056|gb|ABM87113.1| transcription factor Dp-1 [synthetic construct], gi|123987073|gb|ABM8379...
0.0 [1..390] [5..394]
TFDP1_MOUSE - Transcription factor Dp-1 OS=Mus musculus GN=Tfdp1 PE=1 SV=1
0.0 [1..390] [5..394]
gi|73989562 - gi|73989562|ref|XP_849597.1| PREDICTED: similar to Transcription factor Dp-1 (E2F dimerization partn...
0.0 [1..390] [21..410]
TFDP1_BOVIN - Transcription factor Dp-1 OS=Bos taurus GN=TFDP1 PE=2 SV=1
0.0 [1..390] [5..394]
gi|50730508 - gi|50730508|ref|XP_416938.1| PREDICTED: similar to transcription factor [Gallus gallus]
0.0 [1..390] [5..395]
gi|114688131 - gi|114688131|ref|XP_521363.2| PREDICTED: similar to E2F-related transcription factor [Pan troglodyte...
0.0 [1..390] [5..393]
gi|52354615, gi|... - gi|52354615|gb|AAH82841.1| LOC494744 protein [Xenopus laevis], gi|148222844|ref|NP_001088050.1| hypo...
0.0 [1..389] [5..395]

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Predicted Domain #1
Region A:
Residues: [1-105]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGLIEANGEL KVFIDQNLSP GKGVVSLVAV HPSTVNPLGK QLLPKTFGQS NVNIAQQVVI  60
   61 GTPQRPAASN TLVVGSPHTP STHFASQNQP SDSSPWSAGK RNRKG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [106-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKNGKGLRHF SMKVCEKVQR KGTTSYNEVA DELVAEFSAA DNHILPNESA YDQKNIRRRV  60
   61 YDALNVLMAM NIISKEKKEI KWIGL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.69897
Match: 1cf7B
Description: Cell cycle transcription factor DP-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription activator activity 3.70589483230587 bayes_pls_golite062009
sequence-specific DNA binding 3.58179858678904 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
protein binding 1.80415286835431 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.2723726467408 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.23177057841536 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [191-406]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTNSAQECQN LEVERQRRLE RIKQKQSQLQ ELILQQIAFK NLVQRNRHAE QQASRPPPPN  60
   61 SVIHLPFIIV NTSKKTVIDC SISNDKFEYL FNFDNTFEIH DDIEVLKRMG MACGLESGSC 120
  121 SAEDLKMARS LVPKALEPYV TEMAQGTVGG VFITTAGSTS NGTRFSASDL TNGADGMLAT 180
  181 SSNGSQYSGS RVETPVSYVG EDDEEDDDFN ENDEDD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 70.154902
Match: 2azeA
Description: Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle