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View Structure Prediction Details

Protein: gi|49258498
Organism: Homo sapiens
Length: 237 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|49258498.

Description E-value Query
Range
Subject
Range
gi|114627460 - gi|114627460|ref|XP_520345.2| PREDICTED: hypothetical protein [Pan troglodytes]
238.0 [0..1] [236..361]
gi|94366203 - gi|94366203|ref|XP_995211.1| PREDICTED: similar to Retinoic acid receptor RXR-alpha (Retinoid X rece...
236.0 [0..1] [236..229]
gi|83026436 - gi|83026436|gb|ABB96254.1| retinoid X receptor, alpha [Homo sapiens]
233.0 [0..1] [236..212]
gi|148747360, gi... - gi|149039209|gb|EDL93429.1| retinoid X receptor alpha, isoform CRA_a [Rattus norvegicus], gi|1487473...
233.0 [0..1] [236..227]
gi|68396885 - gi|68396885|ref|XP_683221.1| PREDICTED: similar to retinoid X receptor-alpha [Danio rerio]
233.0 [0..1] [236..295]

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Predicted Domain #1
Region A:
Residues: [1-237]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSYELASLPS INALLQAEVL SRQITSPVSG INGDIRAKKI ASIADVCESM KEQLLVLVEW  60
   61 AKYIPAFCEL PLDDQVALLR AHAGEHLLLG ATKRSMVFKD VLLLGNDYIV PRHCPELAEM 120
  121 SRVSIRILDE LVLPFQELQI DDNEYAYLKA IIFFDPDAKG LSDPGKIKRL RSQVQVSLED 180
  181 YINDRQYDSR GRFGELLLLL PTLQSITWQM IEQIQFIKLF GMAKIDNLLQ EMLLGGS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.39794
Match: 1pzlA
Description: Crystal structure of HNF4a LBD in complex with the ligand and the coactivator SRC-1 peptide
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.96722324965091 bayes_pls_golite062009
DNA binding 3.25939553877631 bayes_pls_golite062009
nucleic acid binding 3.16396885393239 bayes_pls_golite062009
transcription activator activity 2.6892852470567 bayes_pls_golite062009
transcription factor activity 2.56099230851339 bayes_pls_golite062009
binding 2.51356324019445 bayes_pls_golite062009
protein binding 2.49676963514373 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 2.20144353900307 bayes_pls_golite062009
sequence-specific DNA binding 2.1684625121246 bayes_pls_golite062009
signal transducer activity 1.57315744720763 bayes_pls_golite062009
molecular transducer activity 1.57315744720763 bayes_pls_golite062009
receptor activity 1.28597420456904 bayes_pls_golite062009
transcription factor binding 0.78455053961808 bayes_pls_golite062009
steroid hormone receptor activity 0.71366308307673 bayes_pls_golite062009
transcription repressor activity 0.49585672359082 bayes_pls_golite062009
catalytic activity 0.477341996033689 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.36233153809872 bayes_pls_golite062009
retinoic acid receptor activity 0.26050147400703 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle