YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|165990377, gi...
Organism:	Yersinia pestis biovar Antiqua str. E1979001
Length:	341 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|165990377, gi....

Description	E-value	Query Range	Subject Range
gi\|167038831, gi... - gi\|167038831\|ref\|YP_001661816.1\| periplasmic binding protein/LacI transcriptional regulator [Thermoa... gi\|242258204, gi... - gi\|242258204\|ref\|ZP_04803030.1\| transcriptional regulator, LacI family [Thermoanaerobacter sp. X513]...	4.0E-93	[2..332]	[3..333]
gi\|20515183, gi\|... - gi\|20806727\|ref\|NP_621898.1\| transcriptional regulator [Thermoanaerobacter tengcongensis MB4], gi\|20... gi\|20806727 - gi\|20806727\|ref\|NP_621898.1\| Transcriptional regulator [Thermoanaerobacter tengcongensis MB4] gi\|254478068, gi... - gi\|254478068\|ref\|ZP_05091451.1\| Periplasmic binding proteins and sugar binding domain of the LacI fa...	8.0E-93	[2..332]	[3..333]
PURR_YERPA - HTH-type transcriptional repressor PurR OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=purR PE=3... gi\|167049637, gi... - gi\|167400784\|ref\|ZP_02306290.1\| purine nucleotide synthesis repressor [Yersinia pestis biovar Antiqu...	3.0E-92	[1..341]	[1..341]
gi\|238719809, gi... - gi\|77961722\|ref\|ZP_00825554.1\| COG1609: Transcriptional regulators [Yersinia mollaretii ATCC 43969],...	4.0E-92	[1..341]	[1..341]
gi\|77959193, gi\|... - gi\|77959193\|ref\|ZP_00823215.1\| COG1609: Transcriptional regulators [Yersinia bercovieri ATCC 43970],...	4.0E-92	[1..341]	[1..341]
PURR_SHIFL - HTH-type transcriptional repressor PurR OS=Shigella flexneri GN=purR PE=3 SV=2 PURR_ECOLI - HTH-type transcriptional repressor purR (Purine nucleotide synthesis repressor) (Pur regulon repress... gi\|30063174, gi\|... - gi\|30063174\|ref\|NP_837345.1\| DNA-binding transcriptional repressor PurR [Shigella flexneri 2a str. 2... PURR_ECO57 - HTH-type transcriptional repressor PurR OS=Escherichia coli O157:H7 GN=purR PE=3 SV=2 PURR_SHIBS - HTH-type transcriptional repressor PurR OS=Shigella boydii serotype 4 (strain Sb227) GN=purR PE=3 SV... EG10800 - transcriptional repressor, hypoxanthine-binding / Purine regulon repressor gi\|15802072, gi\|... - gi\|15802072\|ref\|NP_288094.1\| DNA-binding transcriptional repressor PurR [Escherichia coli O157:H7 ED... PURR_ECOHS - HTH-type transcriptional repressor PurR OS=Escherichia coli O9:H4 (strain HS) GN=purR PE=3 SV=1 gi\|189364893, gi... - gi\|189364893\|gb\|EDU83309.1\| transcriptional repressor PurR [Escherichia coli O157:H7 str. EC4501], g... gi\|187768723, gi... - gi\|187768723\|gb\|EDU32567.1\| transcriptional repressor PurR [Escherichia coli O157:H7 str. EC4196], g... gi\|188998787, gi... - gi\|188998787\|gb\|EDU67773.1\| transcriptional repressor PurR [Escherichia coli O157:H7 str. EC4076], g... PURR_ECOSM - HTH-type transcriptional repressor PurR OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=purR PE=3 SV... gi\|188013794, gi... - gi\|188013794\|gb\|EDU51916.1\| transcriptional repressor PurR [Escherichia coli O157:H7 str. EC4113], g... gi\|254288510, gi... - gi\|254288510\|ref\|YP_003054258.1\| DNA-binding transcriptional repressor, hypoxanthine-binding [Escher... gi\|253973622, gi... - gi\|254161721\|ref\|YP_003044829.1\| DNA-binding transcriptional repressor, hypoxanthine-binding [Escher... PURR_ECOLC - HTH-type transcriptional repressor PurR OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) G... PURR_ECOBW - HTH-type transcriptional repressor PurR OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=purR P... gi\|242377388, gi... - gi\|251785115\|ref\|YP_002999419.1\| hypothetical protein B21_01618 [Escherichia coli BL21], gi\|24237738... PURR_ECOSE - HTH-type transcriptional repressor PurR OS=Escherichia coli (strain SE11) GN=purR PE=3 SV=1 gi\|217318213, gi... - gi\|217328866\|ref\|ZP_03444947.1\| transcriptional repressor PurR [Escherichia coli O157:H7 str. TW1458... PURR_ECO8A - HTH-type transcriptional repressor PurR OS=Escherichia coli O8 (strain IAI1) GN=purR PE=3 SV=1 gi\|254793277, gi... - gi\|254793277\|ref\|YP_003078114.1\| DNA-binding transcriptional repressor, hypoxanthine-binding [Escher... PURR_ECO55 - HTH-type transcriptional repressor PurR OS=Escherichia coli (strain 55989 / EAEC) GN=purR PE=3 SV=1 gi\|208724905, gi... - gi\|208810389\|ref\|ZP_03252265.1\| transcriptional repressor PurR [Escherichia coli O157:H7 str. EC4206... gi\|208731102, gi... - gi\|208816759\|ref\|ZP_03257879.1\| transcriptional repressor PurR [Escherichia coli O157:H7 str. EC4045... gi\|208738523, gi... - gi\|208818400\|ref\|ZP_03258720.1\| transcriptional repressor PurR [Escherichia coli O157:H7 str. EC4042... PURR_ECO5E - HTH-type transcriptional repressor PurR OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=purR P... gi\|193070277, gi... - gi\|193070277\|ref\|ZP_03051221.1\| transcriptional repressor PurR [Escherichia coli E110019], gi\|192956... gi\|194416008, gi... - gi\|194425953\|ref\|ZP_03058509.1\| transcriptional repressor PurR [Escherichia coli B171], gi\|194416008... gi\|194434708, gi... - gi\|194434708\|ref\|ZP_03066961.1\| transcriptional repressor PurR [Shigella dysenteriae 1012], gi\|19441... gi\|195940238 - gi\|195940238\|ref\|ZP_03085620.1\| DNA-binding transcriptional repressor PurR [Escherichia coli O157:H7... PURR_SHIB3 - HTH-type transcriptional repressor PurR OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) ... gi\|188492354, gi... - gi\|188492354\|ref\|ZP_02999624.1\| transcriptional regulator, lacI family [Escherichia coli 53638], gi\|... gi\|190904045, gi... - gi\|191165914\|ref\|ZP_03027751.1\| transcriptional repressor PurR [Escherichia coli B7A], gi\|190904045\|... gi\|193064944, gi... - gi\|193064944\|ref\|ZP_03046020.1\| transcriptional repressor PurR [Escherichia coli E22], gi\|192927431\|... PURR_SHIF8 - HTH-type transcriptional repressor PurR OS=Shigella flexneri serotype 5b (strain 8401) GN=purR PE=3 ... gi\|1742731, gi\|8... - gi\|89108500\|ref\|AP_002280.1\| DNA-binding transcriptional repressor, hypoxanthine-binding [Escherichi... gi\|13361834, gi\|... - gi\|15831621\|ref\|NP_310394.1\| DNA-binding transcriptional repressor PurR [Escherichia coli O157:H7 st... gi\|124498465, gi... - gi\|124531610\|ref\|ZP_01701821.1\| transcriptional regulator, LacI family [Escherichia coli B], gi\|1244... PURR_ECO7I - HTH-type transcriptional repressor PurR OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=purR PE=... PURR_ECOLU - HTH-type transcriptional repressor PurR OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=p... EG10800 - transcriptional repressor, hypoxanthine-binding / Purine regulon repressor	5.0E-92	[1..341]	[1..341]
gi\|77975299, gi\|... - gi\|77975299\|ref\|ZP_00830835.1\| COG1609: Transcriptional regulators [Yersinia frederiksenii ATCC 3364...	7.0E-92	[1..341]	[1..341]
PURR_ECOUT - HTH-type transcriptional repressor PurR OS=Escherichia coli (strain UTI89 / UPEC) GN=purR PE=3 SV=1 PURR_ECOL5 - HTH-type transcriptional repressor PurR OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=purR P... PURR_ECOK1 - HTH-type transcriptional repressor PurR OS=Escherichia coli O1:K1 / APEC GN=purR PE=3 SV=1 gi\|191173444, gi... - gi\|191173444\|ref\|ZP_03034972.1\| transcriptional repressor PurR [Escherichia coli F11], gi\|190906286\|... PURR_ECO27 - HTH-type transcriptional repressor PurR OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=purR... PURR_ECO45 - HTH-type transcriptional repressor PurR OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=purR PE=3... PURR_ECO81 - HTH-type transcriptional repressor PurR OS=Escherichia coli O81 (strain ED1a) GN=purR PE=3 SV=1 gi\|226900363, gi... - gi\|237705606\|ref\|ZP_04536087.1\| purine nucleotide synthesis repressor [Escherichia sp. 3_2_53FAA], g... sp\|B7URZ9\|PURR_ECO27 - HTH-type transcriptional repressor purR OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=purR...	7.0E-92	[1..341]	[1..341]
PURR_SHIDS - HTH-type transcriptional repressor PurR OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=purR PE...	1.0E-91	[1..341]	[1..341]

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Predicted Domain #1

Region A:
Residues: [1-341]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATIKDVAKH AGVSTTTVSH VINKTRFVAE NTKAAVWAAI KELHYSPSAV ARSLKVNHTK  60
   61 SIGLLATSSE APYFAEVIEA VENSCYSKGY TLILCNSHNN LDKQKAYLAM LAQKRVDGLL 120
  121 VMCSEYPDQL LGMLEDYRNI PMVVMDWGTA RGDFTDSIID NAFEGGYLAG RYLIERGHRD 180
  181 IGAIPGQLAR NTGGGRHQGF LKALEEANIP VREEWIVQGD FEPESGYKAM HQILTQKHRP 240
  241 TAVFCGGDIM AMGAICAADE LGLRVPQDIS VIGYDNVRNA RYFSPALTTI HQPKERLGET 300
  301 AFAMLLDRIV SKREDPQTIE VHPKLVERRS VADGPFRDYR R

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	92.69897
Match:	1vpwA
Description:	Purine repressor (PurR), N-terminal domain; Purine repressor (PurR), C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.56046382984539	bayes_pls_golite062009
DNA binding	2.83896385348242	bayes_pls_golite062009
nucleic acid binding	2.80027597752699	bayes_pls_golite062009
transcription factor activity	2.66587775072853	bayes_pls_golite062009
binding	2.28053989162516	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.39285787026752	bayes_pls_golite062009
sequence-specific DNA binding	1.24210127552529	bayes_pls_golite062009
transporter activity	0.69447727045719	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	0.613419400163686	bayes_pls_golite062009
receptor activity	0.581432737510315	bayes_pls_golite062009
transmembrane transporter activity	0.537625088427333	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	0.370742156532721	bayes_pls_golite062009
transmembrane receptor activity	0.244777496593902	bayes_pls_golite062009
protein binding	0.186782087158009	bayes_pls_golite062009
G-protein coupled receptor activity	0.1760601003859	bayes_pls_golite062009
transcription factor binding	0.1642679595723	bayes_pls_golite062009
transcription cofactor activity	0.0349218665655747	bayes_pls_golite062009
substrate-specific transporter activity	0.00441561491566994	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: