YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|170082468, gi...
Organism:	Escherichia coli str. K-12 substr. DH10B
Length:	441 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|170082468, gi....

Description	E-value	Query Range	Subject Range
gi\|81242475, gi\|... - gi\|82778327\|ref\|YP_404676.1\| proline aminopeptidase P II [Shigella dysenteriae Sd197], gi\|81242475\|g...	432.0	[0..1]	[441..1]
gi\|192930878, gi... - gi\|75258508\|ref\|ZP_00729930.1\| COG0006: Xaa-Pro aminopeptidase [Escherichia coli E22], gi\|193063601\|... gi\|75227226, gi\|... - gi\|75227226\|ref\|ZP_00714026.1\| COG0006: Xaa-Pro aminopeptidase [Escherichia coli B7A], gi\|191169456\|... gi\|194426199, gi... - gi\|75212477\|ref\|ZP_00712501.1\| COG0006: Xaa-Pro aminopeptidase [Escherichia coli B171], gi\|194426199... gi\|218362224, gi... - gi\|218555456\|ref\|YP_002388369.1\| proline aminopeptidase P II [Escherichia coli IAI1], gi\|218362224\|e...	431.0	[0..1]	[441..1]
gi\|30042476, gi\|... - gi\|30064219\|ref\|NP_838390.1\| proline aminopeptidase P II [Shigella flexneri 2a str. 2457T], gi\|30042...	430.0	[0..1]	[441..1]
gi\|227888458, gi... - gi\|227888458\|ref\|ZP_04006263.1\| proline aminopeptidase P II [Escherichia coli 83972], gi\|227834727\|g... gi\|26249325, gi\|... - gi\|26249325\|ref\|NP_755365.1\| proline aminopeptidase P II [Escherichia coli CFT073], gi\|26109733\|gb\|A...	430.0	[0..1]	[441..1]
gi\|24053302, gi\|... - gi\|24114161\|ref\|NP_708671.1\| proline aminopeptidase P II [Shigella flexneri 2a str. 301], gi\|2405330...	429.0	[0..1]	[441..1]
gi\|82545470, gi\|... - gi\|82545470\|ref\|YP_409417.1\| proline aminopeptidase P II [Shigella boydii Sb227], gi\|81246881\|gb\|ABB... gi\|187730091, gi... - gi\|75178801\|ref\|ZP_00698837.1\| COG0006: Xaa-Pro aminopeptidase [Shigella boydii BS512], gi\|187730091...	429.0	[0..1]	[441..1]
gi\|253323295, gi... - gi\|254289580\|ref\|YP_003055328.1\| proline aminopeptidase P II [Escherichia coli BL21(DE3)], gi\|253978... gi\|242378439, gi... - gi\|251786166\|ref\|YP_003000470.1\| hypothetical protein B21_02703 [Escherichia coli BL21], gi\|24237843... gi\|253974721, gi... - gi\|254162820\|ref\|YP_003045928.1\| proline aminopeptidase P II [Escherichia coli B str. REL606], gi\|25... gi\|188494686, gi... - gi\|75515308\|ref\|ZP_00737492.1\| COG0006: Xaa-Pro aminopeptidase [Escherichia coli 53638], gi\|18849468... gi\|192956131, gi... - gi\|75234636\|ref\|ZP_00718967.1\| COG0006: Xaa-Pro aminopeptidase [Escherichia coli E110019], gi\|193070... gi\|75196860, gi\|... - gi\|75196860\|ref\|ZP_00706930.1\| COG0006: Xaa-Pro aminopeptidase [Escherichia coli HS], gi\|157162368\|r... gi\|75187624, gi\|... - gi\|75187624\|ref\|ZP_00700891.1\| COG0006: Xaa-Pro aminopeptidase [Escherichia coli E24377A], gi\|157158...	429.0	[0..1]	[441..1]
gi\|75239251, gi\|... - gi\|75239251\|ref\|ZP_00723224.1\| COG0006: Xaa-Pro aminopeptidase [Escherichia coli F11], gi\|191173252\|... gi\|110643056, gi... - gi\|110643056\|ref\|YP_670786.1\| proline aminopeptidase P II [Escherichia coli 536], gi\|110344648\|gb\|AB...	429.0	[0..1]	[441..1]
gi\|110616358, gi... - gi\|110806810\|ref\|YP_690330.1\| proline aminopeptidase P II [Shigella flexneri 5 str. 8401], gi\|110616...	429.0	[0..1]	[441..1]
gi\|218366669, gi... - gi\|218559900\|ref\|YP_002392813.1\| proline aminopeptidase P II [Escherichia coli S88], gi\|218366669\|em... gi\|237706445, gi... - gi\|237706445\|ref\|ZP_04536926.1\| xaa-Pro aminopeptidase [Escherichia sp. 3_2_53FAA], gi\|226899485\|gb\|... gi\|91212287, gi\|... - gi\|91212287\|ref\|YP_542273.1\| proline aminopeptidase P II [Escherichia coli UTI89], gi\|91073861\|gb\|AB... gi\|115514262, gi... - gi\|117625138\|ref\|YP_854126.1\| proline aminopeptidase P II [Escherichia coli APEC O1], gi\|115514262\|g...	428.0	[0..1]	[441..1]

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Predicted Domain #1

Region A:
Residues: [1-441]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEISRQEFQ RRRQALVEQM QPGSAALIFA APEVTRSADS EYPYRQNSDF WYFTGFNEPE  60
   61 AVLVLIKSDD THNHSVLFNR VRDLTAEIWF GRRLGQDAAP EKLGVDRALA FSEINQQLYQ 120
  121 LLNGLDVVYH AQGEYAYADV IVNSALEKLR KGSRQNLTAP ATMIDWRPVV HEMRLFKSPE 180
  181 EIAVLRRAGE ITAMAHTRAM EKCRPGMFEY HLEGEIHHEF NRHGARYPSY NTIVGSGENG 240
  241 CILHYTENEC EMRDGDLVLI DAGCEYKGYA GDITRTFPVN GKFTQAQREI YDIVLESLET 300
  301 SLRLYRPGTS ILEVTGEVVR IMVSGLVKLG ILKGDVDELI AQNAHRPFFM HGLSHWLGLD 360
  361 VHDVGVYGQD RSRILEPGMV LTVEPGLYIA PDAEVPEQYR GIGIRIEDDI VITETGNENL 420
  421 TASVVKKPEE IEALMVAARK Q

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	119.0
Match:	1a16A
Description:	AMINOPEPTIDASE P FROM E. COLI WITH THE INHIBITOR PRO-LEU
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	2.13673980333304	bayes_pls_golite062009
metallopeptidase activity	1.75829852010848	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	1.72257981533668	bayes_pls_golite062009
hydrolase activity	1.67276591010352	bayes_pls_golite062009
protein binding	1.09505761344036	bayes_pls_golite062009
aminopeptidase activity	0.89399203910285	bayes_pls_golite062009
binding	0.863418237728554	bayes_pls_golite062009
exopeptidase activity	0.762255574851485	bayes_pls_golite062009
nucleic acid binding	0.478507702690501	bayes_pls_golite062009
transcription regulator activity	0.151893946259744	bayes_pls_golite062009
catalytic activity	0.148551873544128	bayes_pls_golite062009
DNA binding	0.146627179138465	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: