YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|34811453, gi\|...
Organism:	Geobacillus stearothermophilus
Length:	226 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|34811453, gi|....

Description	E-value	Query Range	Subject Range
gi\|34811270 - gi\|34811270\|pdb\|1P59\|A Chain A, Structure Of A Non-Covalent Endonuclease Iii-Dna Complex	259.0	[0..1]	[226..1]
gi\|27366367, gi\|... - gi\|27366367\|ref\|NP_761895.1\| endonuclease III [Vibrio vulnificus CMCP6], gi\|27362568\|gb\|AAO11422.1\|A...	258.0	[0..5]	[217..1]
gi\|126097154, gi... - gi\|126208362\|ref\|YP_001053587.1\| endonuclease III [Actinobacillus pleuropneumoniae L20], gi\|12609715... gi\|190150214, gi... - gi\|190150214\|ref\|YP_001968739.1\| endonuclease III [Actinobacillus pleuropneumoniae serovar 7 str. AP... gi\|32033526 - gi\|32033526\|ref\|ZP_00133853.1\| COG0177: Predicted EndoIII-related endonuclease [Actinobacillus pleur...	258.0	[0..5]	[213..1]
gi\|37679370, gi\|... - gi\|37679370\|ref\|NP_933979.1\| EndoIII-related endonuclease [Vibrio vulnificus YJ016], gi\|37198113\|dbj...	258.0	[0..5]	[217..1]
gi\|15602246, gi\|... - gi\|15602246\|ref\|NP_245318.1\| hypothetical protein PM0381 [Pasteurella multocida subsp. multocida str...	258.0	[0..5]	[214..1]
gi\|113461208, gi... - gi\|23467008\|ref\|ZP_00122593.1\| COG0177: Predicted EndoIII-related endonuclease [Haemophilus somnus 1... gi\|168825935, gi... - gi\|170717806\|ref\|YP_001784869.1\| endonuclease III [Haemophilus somnus 2336], gi\|168825935\|gb\|ACA3130...	257.0	[0..5]	[214..1]
gi\|28898882, gi\|... - gi\|28898882\|ref\|NP_798487.1\| endonuclease III [Vibrio parahaemolyticus RIMD 2210633], gi\|28807101\|db... gi\|28807101 - gi\|28807101\|dbj\|BAC60371.1\| endonuclease III [Vibrio parahaemolyticus RIMD 2210633]	257.0	[0..5]	[217..1]
gi\|150841122, gi... - gi\|75437253\|ref\|ZP_00733403.1\| endonuclease III [Actinobacillus succinogenes 130Z], gi\|74275861\|gb\|E...	257.0	[0..5]	[216..1]
gi\|77868355, gi\|... - gi\|77952798\|ref\|ZP_00817211.1\| Endonuclease III/Nth [Marinobacter aquaeolei VT8], gi\|77868355\|gb\|EAO...	256.0	[0..5]	[215..1]
gi\|88777366, gi\|... - gi\|88799935\|ref\|ZP_01115507.1\| endonuclease III [Reinekea sp. MED297], gi\|88777366\|gb\|EAR08569.1\| en...	255.0	[0..5]	[214..1]

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Predicted Domain #1

Region A:
Residues: [1-226]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSHMLTKQQI RYCLDEMAKM FPDAHCELVH RNPFELLIAV VLSAQCTDAL VNKVTKRLFE  60
   61 KYRTPHDYIA VPLEELEQDI RSIGLYRNKA RNIQKLCAML IDKYNGEVPR DRDELMKLPG 120
  121 VGRKTANVVV SVAFGVPAIA VDTHVERVSK RLGFCRWDDS VLEVEKTLMK IIPKEEWSIT 180
  181 HHRMIFFGRY HCKAQSPQCP SCPLLHLCRE GKKRMRKREE KAANQK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.30103
Match:	1p59A
Description:	Endonuclease III
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA N-glycosylase activity	4.8124964619976	bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds	4.26870112679392	bayes_pls_golite062009
DNA-(apurinic or apyrimidinic site) lyase activity	3.71152530486175	bayes_pls_golite062009
oxidized base lesion DNA N-glycosylase activity	2.49872706126491	bayes_pls_golite062009
hydrolase activity	2.39042189031819	bayes_pls_golite062009
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	2.21048599823382	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	2.18053745735048	bayes_pls_golite062009
catalytic activity	2.13345932727422	bayes_pls_golite062009
damaged DNA binding	2.00388798014411	bayes_pls_golite062009
alkylbase DNA N-glycosylase activity	1.5832578018127	bayes_pls_golite062009
DNA binding	1.44394874535958	bayes_pls_golite062009
nucleic acid binding	1.36800347239439	bayes_pls_golite062009
oxidized purine base lesion DNA N-glycosylase activity	1.32985950765371	bayes_pls_golite062009
oxidized pyrimidine base lesion DNA N-glycosylase activity	1.2016453685638	bayes_pls_golite062009
binding	1.15752946565805	bayes_pls_golite062009
DNA-3-methyladenine glycosylase I activity	1.06383943982125	bayes_pls_golite062009
uracil DNA N-glycosylase activity	0.879508131574476	bayes_pls_golite062009
structure-specific DNA binding	0.85419760398899	bayes_pls_golite062009
purine-specific mismatch base pair DNA N-glycosylase activity	0.68578837518217	bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity	0.661651574677137	bayes_pls_golite062009
double-stranded DNA binding	0.57099109384393	bayes_pls_golite062009
transcription regulator activity	0.493252955870142	bayes_pls_golite062009
protein binding	0.0921713980805489	bayes_pls_golite062009
carbon-oxygen lyase activity	0.0676784802238829	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: