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View Structure Prediction Details

Protein: gi|42572301
Organism: Arabidopsis thaliana
Length: 466 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|42572301.

Description E-value Query
Range
Subject
Range
gi|19909132 - gi|19909132|gb|AAM03126.1|AF489530_1 GTP cyclohydrolase I [Arabidopsis thaliana]
577.0 [0..1] [466..1]

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Predicted Domain #1
Region A:
Residues: [1-244]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTKDEGCLN LELDIGMKNG CIELAFEHQP ETLAIQDAVK LLLQGLHEDV NREGIKKTPF  60
   61 RVAKALREGT RGYKQKVKDY VQSALFPEAG LDEGVGQAGG VGGLVVVRDL DHYSYCESCL 120
  121 LPFHVKCHIG YVPSGQRVLG LSKFSRVTDV FAKRLQDPQR LADDICSALQ HWVKPAGVAV 180
  181 VLECSHIHFP SLDLDSLNLS SHRGFVKLLV SSGSGVFEDE SSNLWGEFQS FLMFKGVKTQ 240
  241 ALCR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 8.41
Match: 1wm9A
Description: Structure of GTP cyclohydrolase I from Thermus thermophilus HB8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTP cyclohydrolase I activity 4.58215881457764 bayes_pls_golite062009
cyclohydrolase activity 3.1225900680321 bayes_pls_golite062009
GTP cyclohydrolase activity 2.816522292063 bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity 2.34489533040902 bayes_pls_golite062009
catalytic activity 2.02879677696451 bayes_pls_golite062009
dihydroneopterin aldolase activity 1.4000306436633 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1.2538657804327 bayes_pls_golite062009
binding 1.23408359924301 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.627364990614658 bayes_pls_golite062009
protein binding 0.316566321438364 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [245-466]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGSSVKEWCP SVKSSSKLSP EVDPEMVSAV VSILKSLGED PLRKELIATP TRFLKWMLNF  60
   61 QRTNLEMKLN SFNPAKVNGE VKEKRLHCEL NMPFWSMCEH HLLPFYGVVH IGYFCAEGSN 120
  121 PNPVGSSLMK AIVHFYGFKL QVQERMTRQI AETLSPLVGG DVIVVAEAGH TCMISRGIEK 180
  181 FGSSTATIAV LGRFSSDNSA RAMFLDKIHT TNALKTESSS PF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.39794
Match: 1is7A
Description: GTP cyclohydrolase I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTP cyclohydrolase I activity 5.27071565931386 bayes_pls_golite062009
cyclohydrolase activity 3.66553359909123 bayes_pls_golite062009
GTP cyclohydrolase activity 3.44912994722205 bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity 2.94513271787536 bayes_pls_golite062009
catalytic activity 2.20788162511962 bayes_pls_golite062009
dihydroneopterin aldolase activity 1.96466418682643 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1.73101699306211 bayes_pls_golite062009
binding 1.19587307204017 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.974891318710762 bayes_pls_golite062009
protein binding 0.298277659609786 bayes_pls_golite062009
urate oxidase activity 0.0294957696532921 bayes_pls_golite062009

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