YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|21466057
Organism:	Escherichia coli
Length:	281 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|21466057.

Description	E-value	Query Range	Subject Range
gi\|157163401, gi... - gi\|75197799\|ref\|ZP_00707869.1\| COG0580: Glycerol uptake facilitator and related permeases (Major Int...	244.0	[0..1]	[281..1]
gi\|81247687, gi\|... - gi\|82546276\|ref\|YP_410223.1\| facilitated diffusion of glycerol [Shigella boydii Sb227], gi\|81247687\|...	244.0	[0..1]	[281..1]
gi\|82778904, gi\|... - gi\|82778904\|ref\|YP_405253.1\| facilitated diffusion of glycerol [Shigella dysenteriae Sd197], gi\|8124...	244.0	[0..1]	[281..1]
GLPF_ECOL6 - Glycerol uptake facilitator protein OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) G... GLPF_ECO57 - Glycerol uptake facilitator protein OS=Escherichia coli O157:H7 GN=glpF PE=3 SV=1 gi\|188016785, gi... - gi\|188016785\|gb\|EDU54907.1\| glycerol uptake facilitator protein [Escherichia coli O157:H7 str. EC411... EG10396 - glycerol facilitator / Aquaglyceroporin; glycerol facilitator GLPF_ECOL6 - Glycerol uptake facilitator protein OS=Escherichia coli O6 GN=glpF PE=3 SV=1 gi\|15804516, gi\|... - gi\|15804516\|ref\|NP_290556.1\| facilitated diffusion of glycerol [Escherichia coli O157:H7 EDL933], gi... gi\|254795927, gi... - gi\|254795927\|ref\|YP_003080764.1\| glycerol facilitator [Escherichia coli O157:H7 str. TW14359], gi\|25... gi\|253975778, gi... - gi\|254163877\|ref\|YP_003046985.1\| glycerol facilitator [Escherichia coli B str. REL606], gi\|253975778... gi\|254039188, gi... - gi\|254039188\|ref\|ZP_04873238.1\| glycerol uptake facilitator protein [Escherichia sp. 1_1_43], gi\|226... gi\|253326478, gi... - gi\|254290628\|ref\|YP_003056376.1\| glycerol facilitator [Escherichia coli BL21(DE3)], gi\|253979935\|gb\|... gi\|251787190, gi... - gi\|251787190\|ref\|YP_003001494.1\| hypothetical protein B21_03761 [Escherichia coli BL21], gi\|24237946... gi\|238861357, gi... - gi\|238902993\|ref\|YP_002928789.1\| glycerol facilitator [Escherichia coli BW2952], gi\|238861357\|gb\|ACR... gi\|226902897, gi... - gi\|237702960\|ref\|ZP_04533441.1\| glycerol facilitator [Escherichia sp. 3_2_53FAA], gi\|226902897\|gb\|EE... gi\|195937569 - gi\|195937569\|ref\|ZP_03082951.1\| glycerol facilitator [Escherichia coli O157:H7 str. EC4024] gi\|227885331, gi... - gi\|227885331\|ref\|ZP_04003136.1\| MIP family major intrinsic protein channel protein [Escherichia coli... gi\|208808509, gi... - gi\|208808509\|ref\|ZP_03250846.1\| glycerol uptake facilitator protein [Escherichia coli O157:H7 str. E... gi\|208735501, gi... - gi\|208814224\|ref\|ZP_03255553.1\| glycerol uptake facilitator protein [Escherichia coli O157:H7 str. E... gi\|208820853, gi... - gi\|208820853\|ref\|ZP_03261173.1\| glycerol uptake facilitator protein [Escherichia coli O157:H7 str. E... gi\|209159190, gi... - gi\|209397790\|ref\|YP_002273445.1\| glycerol uptake facilitator protein [Escherichia coli O157:H7 str. ... gi\|209914666, gi... - gi\|209921407\|ref\|YP_002295491.1\| glycerol uptake facilitator protein [Escherichia coli SE11], gi\|209... gi\|217322252, gi... - gi\|217326031\|ref\|ZP_03442115.1\| glycerol uptake facilitator protein [Escherichia coli O157:H7 str. T... gi\|218363258, gi... - gi\|218556489\|ref\|YP_002389403.1\| glycerol facilitator [Escherichia coli IAI1], gi\|218363258\|emb\|CAR0... gi\|189367873, gi... - gi\|189367873\|gb\|EDU86289.1\| glycerol uptake facilitator protein [Escherichia coli O157:H7 str. EC450... gi\|168775239, gi... - gi\|187769200\|gb\|EDU33044.1\| glycerol uptake facilitator protein [Escherichia coli O157:H7 str. EC419... gi\|168780843, gi... - gi\|189001508\|gb\|EDU70494.1\| glycerol uptake facilitator protein [Escherichia coli O157:H7 str. EC407... gi\|168786782, gi... - gi\|189373228\|gb\|EDU91644.1\| glycerol uptake facilitator protein [Escherichia coli O157:H7 str. EC869... gi\|189378056, gi... - gi\|189378056\|gb\|EDU96472.1\| glycerol uptake facilitator protein [Escherichia coli O157:H7 str. EC508... gi\|170022062, gi... - gi\|170022062\|ref\|YP_001727016.1\| MIP family channel protein [Escherichia coli ATCC 8739], gi\|1697569... gi\|170083397, gi... - gi\|170083397\|ref\|YP_001732717.1\| glycerol facilitator [Escherichia coli str. K-12 substr. DH10B], gi... gi\|170681277, gi... - gi\|170681277\|ref\|YP_001746312.1\| glycerol uptake facilitator protein [Escherichia coli SMS-3-5], gi\|... EG10396 - glycerol facilitator / Aquaglyceroporin; glycerol facilitator gi\|193068076, gi... - gi\|75238370\|ref\|ZP_00722369.1\| COG0580: Glycerol uptake facilitator and related permeases (Major Int... gi\|75240320, gi\|... - gi\|75240320\|ref\|ZP_00724260.1\| COG0580: Glycerol uptake facilitator and related permeases (Major Int... gi\|194427503, gi... - gi\|75211259\|ref\|ZP_00711358.1\| COG0580: Glycerol uptake facilitator and related permeases (Major Int... gi\|190903498, gi... - gi\|75230448\|ref\|ZP_00716934.1\| COG0580: Glycerol uptake facilitator and related permeases (Major Int... gi\|117626194, gi... - gi\|117626194\|ref\|YP_859517.1\| glycerol uptake facilitator protein [Escherichia coli APEC O1], gi\|115... gi\|73857904, gi\|... - gi\|74314427\|ref\|YP_312846.1\| facilitated diffusion of glycerol [Shigella sonnei Ss046], gi\|73857904\|... gi\|124501290, gi... - gi\|124527588\|ref\|ZP_01699053.1\| MIP family channel proteins [Escherichia coli B], gi\|124501290\|gb\|EA... gi\|85676133, gi\|... - gi\|89110102\|ref\|AP_003882.1\| glycerol facilitator [Escherichia coli str. K-12 substr. W3110], gi\|856... gi\|75258090, gi\|... - gi\|75258090\|ref\|ZP_00729551.1\| COG0580: Glycerol uptake facilitator and related permeases (Major Int... gi\|188491535, gi... - gi\|75513887\|ref\|ZP_00736240.1\| COG0580: Glycerol uptake facilitator and related permeases (Major Int... gi\|194438294, gi... - gi\|83586229\|ref\|ZP_00924865.1\| COG0580: Glycerol uptake facilitator and related permeases (Major Int... gi\|157157499, gi... - gi\|75188662\|ref\|ZP_00701929.1\| COG0580: Glycerol uptake facilitator and related permeases (Major Int... GLPF_ECOLI - Glycerol uptake facilitator protein (Aquaglyceroporin) - Escherichia coli gi\|218367763, gi... - gi\|218560994\|ref\|YP_002393907.1\| glycerol facilitator [Escherichia coli S88], gi\|218367763\|emb\|CAR05... gi\|218692211, gi... - gi\|218692211\|ref\|YP_002400423.1\| glycerol facilitator [Escherichia coli ED1a], gi\|218429775\|emb\|CAR1... gi\|218354373, gi... - gi\|218697641\|ref\|YP_002405308.1\| glycerol facilitator [Escherichia coli 55989], gi\|218354373\|emb\|CAV... gi\|218707551, gi... - gi\|218707551\|ref\|YP_002415070.1\| glycerol facilitator [Escherichia coli UMN026], gi\|218434648\|emb\|CA... gi\|91075042, gi\|... - gi\|91213468\|ref\|YP_543454.1\| glycerol MIP channel [Escherichia coli UTI89], gi\|91075042\|gb\|ABE09923.... gi\|13364328, gi\|... - gi\|15834106\|ref\|NP_312879.1\| glycerol facilitator protein [Escherichia coli O157:H7 str. Sakai], gi\|... gi\|110644263, gi... - gi\|110644263\|ref\|YP_671993.1\| glycerol uptake facilitator protein [Escherichia coli 536], gi\|1103458...	244.0	[0..1]	[281..1]
gi\|187428545, gi... - gi\|75176686\|ref\|ZP_00696814.1\| COG0580: Glycerol uptake facilitator and related permeases (Major Int...	243.0	[0..1]	[281..1]
gi\|194418539, gi... - gi\|83569807\|ref\|ZP_00921256.1\| COG0580: Glycerol uptake facilitator and related permeases (Major Int...	242.0	[0..1]	[281..1]
GLPF_SHIFL - Glycerol uptake facilitator protein OS=Shigella flexneri GN=glpF PE=3 SV=2	242.0	[0..1]	[281..1]
gi\|537250 - gi\|537250\|gb\|AAA21363.1\| glycerol diffusion facilitator protein gi\|537250\|gb\|AAA... - glycerol diffusion facilitator protein	241.0	[0..1]	[281..1]

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Predicted Domain #1

Region A:
Residues: [1-281]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQTSTLKGQ CIAEFLGTGL LIFFGVGCVA ALKVAGASFG QWEISVIFGL GVAMAIYLTA  60
   61 GVSGAHLNPA VTIALWLFAC FDKRKVIPFI VSQVAGAFCA AALVYGLYYN LFFDFEQTHH 120
  121 IVRGSVESVD LAGTFSTYPN PHINFVQAFA VEMVITAILM GLILALTDDG NGVPRGPLAP 180
  181 LLIGLLIAVI GASMGPLTGT AMNPARDFGP KVFAWLAGWG NVAFTGGRDI PYFLVPLFGP 240
  241 IVGAIVGAFA YRKLIGRHLP CDICVVEEKE TTTPSEQKAS L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.522879
Match:	1fx8A
Description:	Glycerol uptake facilitator protein GlpF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
water transmembrane transporter activity	10.3414560257964	bayes_pls_golite062009
water channel activity	10.2169080705067	bayes_pls_golite062009
amide transmembrane transporter activity	8.22334514934522	bayes_pls_golite062009
urea channel activity	8.22334514934522	bayes_pls_golite062009
urea transmembrane transporter activity	8.22334514934522	bayes_pls_golite062009
glycerol transmembrane transporter activity	6.84984722645819	bayes_pls_golite062009
alcohol transmembrane transporter activity	6.65010837320829	bayes_pls_golite062009
polyol transmembrane transporter activity	6.65010837320829	bayes_pls_golite062009
transporter activity	5.23077472964938	bayes_pls_golite062009
pyrimidine transmembrane transporter activity	5.22583580934587	bayes_pls_golite062009
substrate-specific channel activity	5.0695479460357	bayes_pls_golite062009
substrate-specific transporter activity	5.06520190871345	bayes_pls_golite062009
channel activity	5.06054430984045	bayes_pls_golite062009
passive transmembrane transporter activity	5.06054430984045	bayes_pls_golite062009
transmembrane transporter activity	4.83314424546299	bayes_pls_golite062009
glycerol channel activity	4.65460547189577	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity	2.87423888562609	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.82456291801633	bayes_pls_golite062009
organic acid transmembrane transporter activity	1.57078059027065	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	1.57017437613762	bayes_pls_golite062009
nucleobase transmembrane transporter activity	1.34339324336864	bayes_pls_golite062009
purine transmembrane transporter activity	1.34339324336864	bayes_pls_golite062009
binding	1.29002883661034	bayes_pls_golite062009
amine transmembrane transporter activity	1.16825682067665	bayes_pls_golite062009
ion transmembrane transporter activity	0.516648340085278	bayes_pls_golite062009
active transmembrane transporter activity	0.315342449421593	bayes_pls_golite062009
protein binding	0.279304481542405	bayes_pls_golite062009
structural molecule activity	0.180281371901848	bayes_pls_golite062009
cation transmembrane transporter activity	0.141210715822635	bayes_pls_golite062009
metal ion transmembrane transporter activity	0.0368961725897963	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: