YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|9955273
Organism:	Homo sapiens
Length:	86 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|9955273.

Description	E-value	Query Range	Subject Range
gi\|114585545, gi... - gi\|114585547\|ref\|XP_001158643.1\| PREDICTED: nuclear receptor subfamily 2, group C, member 2 isoform ...	135.0	[0..1]	[83..130]
gi\|168278006 - gi\|168278006\|dbj\|BAG10981.1\| orphan nuclear receptor TR4 [synthetic construct] gi\|36950991, gi\|... - gi\|36950991\|ref\|NP_003289.2\| nuclear receptor subfamily 2, group C, member 2 [Homo sapiens], gi\|1195...	135.0	[0..1]	[83..130]
gi\|109098035 - gi\|109098035\|ref\|XP_001091445.1\| PREDICTED: nuclear receptor subfamily 2, group C, member 2 [Macaca ...	134.0	[0..1]	[83..196]
gi\|73984965 - gi\|73984965\|ref\|XP_541755.2\| PREDICTED: similar to nuclear receptor subfamily 2, group C, member 2 [...	134.0	[0..1]	[83..148]
gi\|2143463, gi\|9... - gi\|912822\|gb\|AAB33314.1\| type II zinc finger DNA binding transcription factor [Mus sp.], gi\|2143463\|... gi\|148666900 - gi\|148666900\|gb\|EDK99316.1\| nuclear receptor subfamily 2, group C, member 2, isoform CRA_a [Mus musc...	134.0	[0..1]	[83..144]
NR2C2_MOUSE - Nuclear receptor subfamily 2 group C member 2 OS=Mus musculus GN=Nr2c2 PE=1 SV=1	133.0	[0..1]	[83..111]
NR2C2_RAT - Nuclear receptor subfamily 2 group C member 2 OS=Rattus norvegicus GN=Nr2c2 PE=1 SV=1	133.0	[0..1]	[83..111]

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Predicted Domain #1

Region A:
Residues: [1-86]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRIYKPCFVC QDKSSGYHYG VSACEGCKGF FRRSIQKNMV YTCHRDKNCI INKVTRNRCQ  60
   61 YCRLQKCFEV GMSKESVRND RNKKKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.69897
Match:	1dszA
Description:	Retinoic acid receptor DNA-binding domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.00967542385368	bayes_pls_golite062009
DNA binding	3.60745514727532	bayes_pls_golite062009
nucleic acid binding	3.47256374293954	bayes_pls_golite062009
binding	2.96409924710655	bayes_pls_golite062009
transcription activator activity	2.9532663930699	bayes_pls_golite062009
transcription factor activity	2.90769972671972	bayes_pls_golite062009
sequence-specific DNA binding	2.72967350701574	bayes_pls_golite062009
protein binding	2.44501340584871	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.40923942043513	bayes_pls_golite062009
ligand-dependent nuclear receptor activity	1.49515149729803	bayes_pls_golite062009
transcription factor binding	1.38523780690867	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.26452462867497	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.68943696300126	bayes_pls_golite062009
transcription cofactor activity	0.58115018700114	bayes_pls_golite062009
transcription repressor activity	0.256420113528322	bayes_pls_golite062009
catalytic activity	0.101795606736461	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: