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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 8 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
GCD1
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • GCD11
  • multi-eIF complex
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • GCD2
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • enzyme regulator activity
  • GCD6
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • GCD7
  • mitochondrion
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • enzyme regulator activity
  • GCN3
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • enzyme regulator activity
  • SUI2
  • multi-eIF complex
  • cytoplasm
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • SUI3
  • multi-eIF complex
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    eukaryotic translation initiation factor 2B complex 6.8252E-16 8 5 5 6292
    guanyl-nucleotide exchange factor complex 1.4322E-14 8 7 5 6292
    eukaryotic translation initiation factor 2 complex 1.3495E-9 8 3 3 6292
    multi-eIF complex 7.5348E-8 8 8 3 6292
    protein complex 1.1143E-6 8 1137 8 6292
    macromolecular complex 2.0527E-5 8 1635 8 6292
    cytoplasmic part 5.8228E-4 8 2482 8 6292
    ribosome 4.565E-3 8 290 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translational initiation 1.946E-18 8 42 8 6292
    regulation of translational initiation 3.1457E-13 8 11 5 6292
    translation 1.5155E-10 8 376 8 6292
    regulation of translation 2.7991E-9 8 57 5 6292
    posttranscriptional regulation of gene expression 3.9707E-9 8 61 5 6292
    regulation of cellular protein metabolic process 6.938E-9 8 68 5 6292
    regulation of protein metabolic process 1.0696E-8 8 74 5 6292
    cellular protein metabolic process 7.0519E-7 8 1074 8 6292
    protein metabolic process 1.1064E-6 8 1136 8 6292
    cellular macromolecule biosynthetic process 1.5738E-6 8 1187 8 6292
    macromolecule biosynthetic process 1.5953E-6 8 1189 8 6292
    gene expression 2.9372E-6 8 1283 8 6292
    cellular biosynthetic process 1.4602E-5 8 1567 8 6292
    biosynthetic process 1.7431E-5 8 1602 8 6292
    regulation of gene expression 8.1056E-5 8 445 5 6292
    regulation of macromolecule biosynthetic process 9.1208E-5 8 456 5 6292
    regulation of cellular biosynthetic process 1.0772E-4 8 472 5 6292
    regulation of biosynthetic process 1.0883E-4 8 473 5 6292
    regulation of macromolecule metabolic process 1.2649E-4 8 488 5 6292
    regulation of primary metabolic process 1.6235E-4 8 514 5 6292
    regulation of cellular metabolic process 1.9849E-4 8 536 5 6292
    regulation of metabolic process 2.1877E-4 8 547 5 6292
    cellular macromolecule metabolic process 3.0018E-4 8 2285 8 6292
    macromolecule metabolic process 3.7455E-4 8 2349 8 6292
    regulation of cellular process 1.2889E-3 8 796 5 6292
    regulation of biological process 1.5139E-3 8 824 5 6292
    primary metabolic process 2.0036E-3 8 2896 8 6292
    cellular metabolic process 2.9013E-3 8 3033 8 6292
    metabolic process 3.9991E-3 8 3157 8 6292
    biological regulation 8.8033E-3 8 1213 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation initiation factor activity 3.6603E-20 8 27 8 6292
    translation factor activity, nucleic acid binding 2.9221E-18 8 44 8 6292
    guanyl-nucleotide exchange factor activity 3.3811E-10 8 38 5 6292
    nucleic acid binding 1.5174E-8 8 666 8 6292
    GTPase regulator activity 2.0416E-8 8 84 5 6292
    nucleoside-triphosphatase regulator activity 3.8147E-8 8 95 5 6292
    enzyme regulator activity 1.8981E-6 8 207 5 6292
    binding 3.1454E-6 8 1294 8 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle