YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 23 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ISA2
  • mitochondrial intermembrane space
  • mitochondrion
  • iron ion transport
  • response to drug
  • biotin biosynthetic process
  • molecular_function
  • PUF4
  • cytoplasm
  • loss of chromatin silencing involved in replicative cell aging
  • protein localization
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL12B, RPL12A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • regulation of translation
  • translational termination
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL18A, RPL18B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL21A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL29
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL9A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS14A
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS22A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • telomere maintenance
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS5
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • small ribosomal subunit
  • 90S preribosome
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 7.1591E-27 23 101 17 6292
    cytosolic part 2.2548E-25 23 122 17 6292
    ribosomal subunit 3.1397E-22 23 183 17 6292
    cytosolic large ribosomal subunit 1.4348E-21 23 60 13 6292
    cytosol 6.6296E-19 23 284 17 6292
    ribosome 9.5031E-19 23 290 17 6292
    large ribosomal subunit 6.8327E-18 23 110 13 6292
    ribonucleoprotein complex 4.5383E-16 23 514 18 6292
    non-membrane-bounded organelle 4.6243E-10 23 959 17 6292
    intracellular non-membrane-bounded organelle 4.6243E-10 23 959 17 6292
    macromolecular complex 2.2652E-7 23 1635 18 6292
    cytosolic small ribosomal subunit 9.2267E-6 23 38 4 6292
    organelle part 4.726E-5 23 2282 18 6292
    intracellular organelle part 4.726E-5 23 2282 18 6292
    small ribosomal subunit 1.2499E-4 23 73 4 6292
    cytoplasmic part 1.7085E-4 23 2482 18 6292
    cytoplasm 3.2262E-4 23 3552 21 6292
    stress granule 3.6554E-3 23 1 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 2.671E-24 23 376 21 6292
    cellular macromolecule biosynthetic process 1.8717E-15 23 1187 22 6292
    macromolecule biosynthetic process 1.9423E-15 23 1189 22 6292
    gene expression 1.0325E-14 23 1283 22 6292
    cellular protein metabolic process 1.1402E-14 23 1074 21 6292
    cellular biosynthetic process 1.1521E-14 23 1567 23 6292
    biosynthetic process 1.9216E-14 23 1602 23 6292
    protein metabolic process 3.662E-14 23 1136 21 6292
    cellular macromolecule metabolic process 2.964E-9 23 2285 22 6292
    macromolecule metabolic process 5.3764E-9 23 2349 22 6292
    ribosomal subunit assembly 3.0372E-8 23 55 6 6292
    cellular metabolic process 4.9214E-8 23 3033 23 6292
    ribosome assembly 7.6919E-8 23 64 6 6292
    organelle assembly 1.2156E-7 23 69 6 6292
    metabolic process 1.241E-7 23 3157 23 6292
    primary metabolic process 4.7706E-7 23 2896 22 6292
    ribonucleoprotein complex assembly 6.8525E-7 23 92 6 6292
    ribosomal large subunit assembly 1.2567E-5 23 41 4 6292
    cellular macromolecular complex assembly 3.6131E-5 23 182 6 6292
    ribosomal large subunit biogenesis 7.9268E-5 23 65 4 6292
    cellular macromolecular complex subunit organization 2.5645E-4 23 259 6 6292
    cellular process 3.0112E-4 23 4426 23 6292
    macromolecular complex assembly 3.9879E-4 23 281 6 6292
    regulation of translation 1.0978E-3 23 57 3 6292
    ribosomal small subunit assembly 1.1326E-3 23 14 2 6292
    ribosome biogenesis 1.2026E-3 23 346 6 6292
    posttranscriptional regulation of gene expression 1.3375E-3 23 61 3 6292
    macromolecular complex subunit organization 1.4152E-3 23 357 6 6292
    ribonucleoprotein complex biogenesis 1.7998E-3 23 374 6 6292
    regulation of cellular protein metabolic process 1.8317E-3 23 68 3 6292
    cellular component assembly 2.0884E-3 23 385 6 6292
    regulation of protein metabolic process 2.3356E-3 23 74 3 6292
    response to cycloalkane 3.6554E-3 23 1 1 6292
    response to organic cyclic substance 3.6554E-3 23 1 1 6292
    response to cycloheximide 3.6554E-3 23 1 1 6292
    ribosomal small subunit biogenesis 3.9386E-3 23 26 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 1.061E-29 23 212 21 6292
    structural molecule activity 2.881E-25 23 339 21 6292
    RNA binding 1.6328E-3 23 367 6 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle