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Protein Overview: BCH1

General Information:
Name(s) found: BCH1 / YMR237W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 724 amino acids

    Gene Ontology:
    Cellular Component: ribosome [IDALink to PubMed article]
    clathrin-coated vesicle [IDALink to PubMed article]
    Biological Process: Golgi to plasma membrane transport [IGILink to PubMed article]
    cell wall chitin biosynthetic process [IGILink to PubMed article][IPILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSQTSIPEV KEDVIGYALH QRRARVGQFQ DLGPPDLITL IKSLPSSSST TTATASANDN  60
   61 GATSNINGQD PTTIVTELHS HDKLKGQIGT FFYCMGIDTS DPTSITIFAK KITDLFLDTP 120
  121 QIWFGKKKHF HVSKISISSW NAFRKYDVNI IVHIPGTVQT YIINSDGEQS QLPSVAEASS 180
  181 GRNSQDLNVN MIWAETFMSG IVRDIMIMKD NRADGESQNL VETLIFNPFT SGELEDVANN 240
  241 FIKLFPLVYE KGVYLDAPTH VLNPSLTNNY LVETLVEIVR LTKSLEACRK MLKKLIEIHP 300
  301 EAVIILIRVY FACDLEIDAV DLINEQLNSP SSFLADDSKT SHIQLIFKSE LLSIQSEFLL 360
  361 DVKRDYKLAK EVAMEAVNCA PNEFKTWYLL TRIYIKLNDM SNALLSLNAC PMSQVKEKYV 420
  421 LRRIAPITSD ENLHLPLPLD ASIEEISSLN PMDVQLEQKS ADPNLVNLSA SSLKSTFQLA 480
  481 YKLLTEIVQI TGWEQLLKYR SKIFVMEDEY QGSTSSIDEA EVRGNDISKM RSKRLCERWL 540
  541 DNLFMLLYED LKTYTDWQSE QLYFDAQNSK YHKLTVEWEL FGLCAKRLGH LPEAAKAFQI 600
  601 GLSQRFSPVC AKNLLQFYID EHKRIRRDSV SANSELTSSQ ILSSINDIDS SIIDLVVKIC 660
  661 CWNHRWYIEF SIILIDALSV AVQDMGITKV HNEIASRFSD PVAQLIDDNI LNFLKNFTND 720
  721 TFDN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BCH1 BCH2 CHS5
    View Details Krogan NJ, et al. (2006) BCH1 BCH2 CHS5 LAP2 MAE1
    View Details Gavin AC, et al. (2006) BCH1 BUD7 CHS5 CHS6
    View Details Qiu et al. (2008) BCH1 BCH2 CHS6 ENT3 YOS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data BCH1 Huh WK, et al. (2003)
    View Data BCH1 and CHC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..415] deduced N/A No confident structure predictions are available.
    2 View Details [416..724] MSA 1.008926 View MSA. No confident structure predictions are available.
    3 View Details [637..724] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • drug binding
    		•  1.97908029685084 bayes_pls_golite062009
  • binding
    		•  1.52138759558575 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.27878246750316 bayes_pls_golite062009
  • isomerase activity
    		•  1.19192091517095 bayes_pls_golite062009
  • catalytic activity
    		•  0.838457647933563 bayes_pls_golite062009
  • transporter activity
    		•  0.741927397485699 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.489382802264305 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.18557772671331 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  0.161213797497172 bayes_pls_golite062009
  • protein binding
    		•  0.104527660115896 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  0.102982189630575 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle