YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: HOC1

General Information:
Name(s) found: HOC1 / YJR075W [SGD]
Description(s) found:
Found 33 descriptions.
SHOW ALL
  • Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 396 amino acids

    Gene Ontology:
    Cellular Component: alpha-1,6-mannosyltransferase complex [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: cell wall mannoprotein biosynthetic process [TASLink to PubMed article]
    substituted mannan metabolic process [TASLink to PubMed article]
    Molecular Function: transferase activity, transferring glycosyl groups [ISSLink to PubMed article]
    alpha-1,6-mannosyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKTTKRASS FRRLMIFAII ALISLAFGVR YLFHNSNATD LQKILQNLPK EISQSINSAN  60
   61 NIQSSDSDLV QHFESLAQEI RHQQEVQAKQ FDKQRKILEK KIQDLKQTPP EATLRERIAM 120
  121 TFPYDSHVKF PAFIWQTWSN DEGPERVQDI KGMWESKNPG FAHEVLNHDV INALVHHYFY 180
  181 SIPEILETYE ALPSIILKID FFKYLILLVH GGVYADIDTF PVQPIPNWIP EELSPSDIGL 240
  241 IVGVEEDAQR ADWRTKYIRR LQFGTWIIQA KPGHPVLREI ISRIIETTLQ RKRDDQLNVN 300
  301 LRNDLNIMSW TGSGLWTDTI FTYFNDFMRS GVREKVTWKL FHNLNQPKLL SDVLVFPKFS 360
  361 FNCPNQIDND DPHKKFYFIT HLASQFWKNT PKVEQK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ANP1 HOC1 MNN10 MNN11 MNN9
    View Details Gavin AC, et al. (2006) ANP1 HOC1 MNN10 MNN11 MNN9
    View Details Qiu et al. (2008) ANP1 GNT1 HOC1 MNN10 MNN11 MNN5 MNN9 OCH1 VAN1 VRG4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX13 - trans-SNARE complex forms but fusion is blocked. Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ROM2 HOC1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HOC1 and ANP1 Huh WK, et al. (2003)
    View Data HOC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..328] MSA 7.042971 View MSA. No confident structure predictions are available.
    2 View Details [329..396] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • UDP-glycosyltransferase activity
    		•  6.01354989568484 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  5.98555597307566 bayes_pls_golite062009
  • acetylgalactosaminyltransferase activity
    		•  5.66606808201136 bayes_pls_golite062009
  • alpha-1,2-mannosyltransferase activity
    		•  5.62955108548526 bayes_pls_golite062009
  • polypeptide N-acetylgalactosaminyltransferase activity
    		•  5.60505224219681 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  5.1732667004955 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  4.02812104984198 bayes_pls_golite062009
  • transferase activity
    		•  2.3313878748424 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.79751747857925 bayes_pls_golite062009
  • catalytic activity
    		•  1.73979371332125 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.47767908405723 bayes_pls_golite062009
  • N-acetyllactosamine synthase activity
    		•  0.925872529464618 bayes_pls_golite062009
  • lactose synthase activity
    		•  0.925872529464618 bayes_pls_golite062009
  • cytidylyltransferase activity
    		•  0.450701661234496 bayes_pls_golite062009
  • alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
    		•  0.386636074342689 bayes_pls_golite062009
  • binding
    		•  0.165472828059574 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle