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Protein Overview: CIR1

General Information:
Name(s) found: CIR1 / YGR207C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Protein that interacts with frataxin (Yfh1p); putative homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 261 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAKQQLRIL VPVKRVVDFQ IKPRVNKTLT GIETSGIKFS INPFDDIAVE EAIRIKEKNK  60
   61 SLVESTHAVS IGSAKAQDIL RNCLAKGIDT CSLIDSVGKE NIEPLAIAKI LKAVVEKKGS 120
  121 NLVLMGKQAI DDDCNNTGQM LAGLLNWPQA TNAAKVEFLD NGRVQVTREI DDGEEVIEAS 180
  181 LPMVITTDLR LNTPRYVGLP KLMKAKKKPI EKLDIAKDFP EINIEPQLKI VSMEEPKTKS 240
  241 PGVKLNSVDE LIEKLKEVKA I

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) AIM45 ALD4 CIR1 CIR2 CIT1 CYB2 DLD1 FUM1 GUT2 MDH1 NDE1 NDE2 NDI1 SDH1
    View Details Krogan NJ, et al. (2006) BIO3 CIR1 NEJ1 ROD1 SOL4
    View Details Qiu et al. (2008) CIR1 NDE1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CIR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..261] PSI-BLAST 650.124002 Small, beta subunit of electron transfer flavoprotein ETFP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.91619517870463 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.38436645708366 bayes_pls_golite062009
  • DNA binding
    		•  1.35936746868519 bayes_pls_golite062009
  • ligase activity
    		•  1.13489674466232 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.883268134837366 bayes_pls_golite062009
  • catalytic activity
    		•  0.828867994386867 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.724532065311415 bayes_pls_golite062009
  • electron carrier activity
    		•  0.40873603017227 bayes_pls_golite062009
  • transferase activity
    		•  0.40273889227698 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle