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Protein Overview: AIM45

General Information:
Name(s) found: AIM45 / YPR004C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Protein with similarity to mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 344 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: electron carrier activity [NASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKSLAAVLP RASKAKFLQK NYASTLAFIE SSKDGSVSRS SLSLLAAAQK LSNPITAVIT  60
   61 GSKAEKTAEA LKSSYSCSNL EKLVIFEDSK LDTCLPEQLT PLLVKLLKGG DYSHFVVSNS 120
  121 SVGKSVLPRV GALLDVQPVC EVTVIKDPKT FIRPIYAGNI ISTIECQAEK KLLIIRASAF 180
  181 PPIAEGSMDS VTIEKRTDIP PCDLNVTWVK TILTKSERPE LTSAQNVVTG GRALKDKETF 240
  241 EKLLSPLADV LHAAIGATRA SVDNGLCDNS LQIGQTGKVV APNLYIAIGV SGAVQHLAGM 300
  301 KDSKVIVAIN NDPDAPIFNV ADYGLQGDLY KIVPELTEKL GKYK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) AIM45 ALD4 CIR1 CIR2 CIT1 CYB2 DLD1 FUM1 GUT2 MDH1 NDE1 NDE2 NDI1 SDH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data AIM45 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..212] PSI-BLAST 827.533179 Large, alpha subunit of electron transfer flavoprotein ETFP, N-terminal domain; C-terminal domain of the electron transfer flavoprotein alpha subunit
    2 View Details [213..344] PSI-BLAST 827.533179 Large, alpha subunit of electron transfer flavoprotein ETFP, N-terminal domain; C-terminal domain of the electron transfer flavoprotein alpha subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrogen ion transmembrane transporter activity
    		•  4.33384561938284 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  4.17090195647007 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.43050424621229 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.14018048674666 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.86768332627553 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.45193593399776 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.3220778881858 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  2.31136100530959 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  1.78592865044375 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  1.78592865044375 bayes_pls_golite062009
  • histone deacetylase activity
    		•  1.78491508784517 bayes_pls_golite062009
  • protein deacetylase activity
    		•  1.78342765644164 bayes_pls_golite062009
  • electron carrier activity
    		•  1.52362724809555 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  1.45879345100257 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  1.4419048058443 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.38926599384969 bayes_pls_golite062009
  • binding
    		•  1.19942441653074 bayes_pls_golite062009
  • deacetylase activity
    		•  1.06362010083501 bayes_pls_golite062009
  • ligase activity
    		•  1.02544349488516 bayes_pls_golite062009
  • GMP synthase (glutamine-hydrolyzing) activity
    		•  0.800567195533497 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • transcription factor binding
    		•  0.53102732418854 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.511639683598669 bayes_pls_golite062009
  • protein binding
    		•  0.498410485514887 bayes_pls_golite062009
  • DNA binding
    		•  0.42016159460068 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.401471604772125 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.38398632593091 bayes_pls_golite062009
  • transferase activity
    		•  0.105059877056256 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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