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Protein Overview: zen-4

General Information:
Name(s) found: zen-4 / CE31717 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00006974 locus:zen-4 status:Confirmed UniProt:Q8MQ04 protein_id:CCD72299.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 777 amino acids

    Gene Ontology:
    Cellular Component: cleavage furrow [IDALink to PubMed article]
    microtubule associated complex [IEALink to PubMed article]
    Biological Process: embryonic cleavage [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    cytokinesis [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    microtubule-based movement [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article][ISSLink to PubMed article]
    microtubule motor activity [IEALink to PubMed article]
    plus-end-directed microtubule motor activity [ISSLink to PubMed article]
    microtubule binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSRKRGITP SRDQVRRKKL SIEETDSIEV VCRLCPYTGS TPSLIAIDEG SIQTVLPPAQ  60
   61 FRRENAPQVE KVFRFGRVFS ENDGQATVFE RTSVDLILNL LKGQNSLLFT YGVTGSGKTY 120
  121 TMTGKPTETG TGLLPRTLDV IFNSINNRVE KCIFYPSALN TFEIRATLDA HLKRHQMAAD 180
  181 RLSTSREITD RYCEAIKLSG YNDDMVCSVF VTYVEIYNNY CYDLLEDARN GSRVLTKREI 240
  241 RHDRQQQMYV DGAKDVEVSS SEEALEVFCL GEERRRVSST LLNKDSSRSH SVFTIKLVMA 300
  301 PRAYETKSVY PTMDSSQIIV SQLCLVDLAG SERAKRTQNV GERLAEANSI NQSLMTLRQC 360
  361 IEVLRRNQKS SSQNLEQVPY RQSKLTHLFK NYLEGNGKIR MVICVNPKPD DYDENMSALA 420
  421 FAEESQTIEV KKQVERMPSE RIPHSFFTQW NSELDGSVRM EDDGSREIPC PPTFCLTDCN 480
  481 DKDTVDSMYK YARKLSSLQN SSEEGPSSTL LTMIRQYMME ADYQRVEIAR LKDSLNDKDE 540
  541 EIKKLRGFCS RYKRENASMK ERIASCEQGE QENALVMEKL MEQKMEDRKI IQSQKKAMRN 600
  601 VRGIIDNPSP SVASLRSRFD QENVAHPTAP IQTPPPPYQT PGRAPVFKKR LEATTSTTVM 660
  661 SGSSSGGSGQ QGYVNPKYQR RSKSASRLLD HQPLHRVPTG TVLQSRTPAN AIRTTKPEMH 720
  721 QLNKSGEYRL THQEVDDEGN ISTNIVKGNV IPTVSGGTAV FFNDIERLTH ESPSTRK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..341] PSI-BLAST 72.69897 Kinesin
    2 View Details [342..777] PSI-BLAST 15.69897 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • microtubule motor activity
    		•  7.68336791348661 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  4.97507344344589 bayes_pls_golite062009
  • microfilament motor activity
    		•  4.176620576177 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  2.77140616759165 bayes_pls_golite062009
  • tubulin binding
    		•  2.67743463093593 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • microtubule binding
    		•  2.59155206524122 bayes_pls_golite062009
  • transporter activity
    		•  2.58140740499725 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.39695871109024 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.18396165590908 bayes_pls_golite062009
  • actin binding
    		•  1.75397031486306 bayes_pls_golite062009
  • hydrolase activity
    		•  1.57549510726226 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  1.36713729043205 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.29730375126024 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.07479235523606 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.906554174337376 bayes_pls_golite062009
  • helicase activity
    		•  0.79055709374547 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.777787753097919 bayes_pls_golite062009
  • actin filament binding
    		•  0.728264616959762 bayes_pls_golite062009
  • DNA binding
    		•  0.479412476059825 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.434775387083003 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.355466224802969 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312171320541728 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.294474570607914 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.282352478532746 bayes_pls_golite062009
  • GTPase activity
    		•  0.265618217985541 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.220608508617331 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.219533217661421 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.219157471322311 bayes_pls_golite062009
  • protein transporter activity
    		•  0.178442534411253 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.17029946873911 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.132012746266431 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.121792392568515 bayes_pls_golite062009
  • GTP binding
    		•  0.119757493758508 bayes_pls_golite062009
  • minus-end-directed microtubule motor activity
    		•  0.068779631341469 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0463883764000663 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0254369227200564 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle