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Protein Overview: rad16

General Information:
Name(s) found: rad16 / SPCC970.01 [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • DNA repair endonuclease XPF [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 892 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article][IDALink to PubMed article]
    nucleotide-excision repair complex [ISSLink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    Biological Process: nucleotide-excision repair, DNA incision, 5'-to lesion [TASLink to PubMed article]
    meiotic gene conversion [IMPLink to PubMed article]
    nucleotide-excision repair [IGILink to PubMed article]
    gene conversion at mating-type locus [IMPLink to PubMed article]
    Molecular Function: DNA binding [ISSLink to PubMed article]
    protein heterodimerization activity [IPILink to PubMed article]
    single-stranded DNA specific endodeoxyribonuclease activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METKVHLPLA YQQQVFNELI EEDGLCVIAP GLSLLQIAAN VLSYFAVPGS LLLLVGANVD  60
   61 DIELIQHEME SHLEKKLITV NTETMSVDKR EKSYLEGGIF AITSRILVMD LLTKIIPTEK 120
  121 ITGIVLLHAD RVVSTGTVAF IMRLYRETNK TGFIKAFSDD PEQFLMGINA LSHCLRCLFL 180
  181 RHVFIYPRFH VVVAESLEKS PANVVELNVN LSDSQKTIQS CLLTCIESTM RELRRLNSAY 240
  241 LDMEDWNIES ALHRSFDVIV RRQLDSVWHR VSPKTKQLVG DLSTLKFLLS ALVCYDCVSF 300
  301 LKLLDTLVLS VNVSSYPSNA QPSPWLMLDA ANKMIRVARD RVYKESEGPN MDAIPILEEQ 360
  361 PKWSVLQDVL NEVCHETMLA DTDAETSNNS IMIMCADERT CLQLRDYLST VTYDNKDSLK 420
  421 NMNSKLVDYF QWREQYRKMS KSIKKPEPSK EREASNTTSR KGVPPSKRRR VRGGNNATSR 480
  481 TTSDNTDAND SFSRDLRLEK ILLSHLSKRY EPEVGNDAFE VIDDFNSIYI YSYNGERDEL 540
  541 VLNNLRPRYV IMFDSDPNFI RRVEVYKATY PKRSLRVYFM YYGGSIEEQK YLFSVRREKD 600
  601 SFSRLIKERS NMAIVLTADS ERFESQESKF LRNVNTRIAG GGQLSITNEK PRVRSLYLMF 660
  661 ICIKTLKVIV DLREFRSSLP SILHGNNFSV IPCQLLVGDY ILSPKICVER KSIRDLIQSL 720
  721 SNGRLYSQCE AMTEYYEIPV LLIEFEQHQS FTSPPFSDLS SEIGKNDVQS KLVLLTLSFP 780
  781 NLRIVWSSSA YVTSIIFQDL KAMEQEPDPA SAASIGLEAG QDSTNTYNQA PLDLLMGLPY 840
  841 ITMKNYRNVF YGGVKDIQEA SETSERKWSE LIGPEAGRRL YSFFRKQLKD YE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..514] PSI-BLAST 56.39794 Crystal structure of Pyrococcus furiosus Hef helicase domain
    2 View Details [515..626] FFAS03 2.64 Crystal structure of Pyrococcus furiosus Hef helicase domain
    3 View Details [627..892] PSI-BLAST 39.0 XPF from Aeropyrum pernix, complex with DNA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • single-stranded DNA specific endodeoxyribonuclease activity
    		•  12.5797089932289 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  7.65460057398582 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  6.8949486660401 bayes_pls_golite062009
  • endonuclease activity
    		•  6.81743235298471 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  4.48421726286311 bayes_pls_golite062009
  • DNA helicase activity
    		•  4.45575761476577 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  3.51692202399009 bayes_pls_golite062009
  • excinuclease ABC activity
    		•  3.48615352002265 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  3.44605832131927 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  3.37084035853131 bayes_pls_golite062009
  • damaged DNA binding
    		•  2.98078816242626 bayes_pls_golite062009
  • DNA binding
    		•  2.97855002479178 bayes_pls_golite062009
  • helicase activity
    		•  2.83648239124034 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.79236389919005 bayes_pls_golite062009
  • nuclease activity
    		•  2.20113675721212 bayes_pls_golite062009
  • binding
    		•  2.17324322139334 bayes_pls_golite062009
  • hydrolase activity
    		•  2.07039693890326 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.69645042781713 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.26255690081743 bayes_pls_golite062009
  • transposase activity
    		•  1.10140160488189 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.05548921907953 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.02983374615445 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.01049916010827 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.00920723797259 bayes_pls_golite062009
  • catalytic activity
    		•  0.816447099398022 bayes_pls_golite062009
  • protein binding
    		•  0.71091195096997 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.76

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle