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Protein Overview: Axn-PA, Axn-PB

General Information:
Name(s) found: Axn-PB / FBpp0084921 [FlyBase]
Axn-PA / FBpp0084919 [FlyBase]
Description(s) found:
Found 38 descriptions.
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  • The gene Axin is referred to in FlyBase by the symbol Dmel\Axn (CG7926, FBgn0026597). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:25848566..25861033. It has the cytological map location 99D2-99D3. It is reported to have molecular function</span>: beta-catenin binding. There is experimental evidence that it is involved in the biological process</span>: eye-antennal disc morphogenesis; negative regulation of Wnt receptor signaling pathway; oogenesis; Wnt receptor signaling pathway; phagocytosis, engulfment. 36 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; adult segment; thoracic segment; portion of tissue; cuticle; embryonic/larval tracheal system; adult; peripheral nervous system; nervous system; embryonic/larval dorsal branch; tracheal system; external compound sense organ. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
  • The gene Axin is referred to in FlyBase by the symbol Dmel\Axn (CG7926, FBgn0026597). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:25848566..25861033. It has the cytological map location 99D2-99D3. It is reported to have molecular function</span>: beta-catenin binding. There is experimental evidence that it is involved in the biological process</span>: eye-antennal disc morphogenesis; negative regulation of Wnt receptor signaling pathway; oogenesis; Wnt receptor signaling pathway; phagocytosis, engulfment. 36 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; adult segment; thoracic segment; portion of tissue; cuticle; embryonic/larval tracheal system; adult; peripheral nervous system; nervous system; embryonic/larval dorsal branch; tracheal system; external compound sense organ. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 745 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [NAS]
    intracellular [IEA]
    Biological Process: phagocytosis, engulfment [IMP]
    oogenesis [IMP]
    Wnt receptor signaling pathway [IGI][ISS]
    eye-antennal disc morphogenesis [IMP]
    negative regulation of Wnt receptor signaling pathway [IDA][NAS]
    Molecular Function: beta-catenin binding [NAS]
    signal transducer activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGHPSGIRK HDDNECSGPR PPVPGEESRV KKMTEGVADT SKNSSPSYLN WARTLNHLLE  60
   61 DRDGVELFKK YVEEEAPAYN DHLNFYFACE GLKQQTDPEK IKQIIGAIYR FLRKSQLSIS 120
  121 DDLRAQIKAI KTNPEIPLSP HIFDPMQRHV EVTIRDNIYP TFLCSEMYIL YIQQMSAQQE 180
  181 RCTSSGATGS GSAGSSGSGG SSLAGACALP PTTASGKQQL PQLVPPGAFI NLPVSSVSGP 240
  241 PAGTCSASGS VYGPSTSASS SGSISATDTL PRSSTLPTLH EDSVLSLCDD FEKVQMQEGG 300
  301 GSLGSGSVGA GARAPDYPIR LTRDLLIATQ KRRLEIRPPG AHGYVYNPST TNTSYVPNSR 360
  361 VDSERASVSS GGRTDSDTMS ISSCSMDGRP YIQRRHSSTE SKAIRQSAMA NKETNTFQVI 420
  421 PRTQRLHSNE HRPLKEEELV SLLIPKLEEV KRKRDLEERA RERNPGAALL TNERSSASDR 480
  481 AFAEAIREKF ALDEDNDQDI LDQHVSRVWK DQTPHRSPGT MSPCPPIPSR RRTATHDSGM 540
  541 VSDGAMSLSG HSMKHSKSMP DHSSCSRKLT NKWPSMNTDS GISMFSADTV TKYKDASSRS 600
  601 GSSTASKLEE AKRRLEDEPR RSRRYAQPPM QHLSQQPLAS FSSSSSGGSI SLPHQPPPLP 660
  661 AKPPETIVVF SFCEEPVPYR IKIPGTQPTL RQFKDYLPRR GHFRFFFKTH CEDPDSPVIQ 720
  721 EEIVNDSDIL PLFGDKAMGL VKPSD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..184] PSI-BLAST 45.221849 Regulator of G-protein signalling 4, RGS4
    2 View Details [185..277] deduced N/A No confident structure predictions are available.
    3 View Details [278..468] MSA 5.111996 View MSA. No confident structure predictions are available.
    4 View Details [469..664] MSA 2.090985 View MSA. No confident structure predictions are available.
    5 View Details [665..745] PSI-BLAST 36.221849 Crystal structure of axin dix domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • GTPase regulator activity
    		•  1.92987277493861 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.90800479999702 bayes_pls_golite062009
  • GTPase activator activity
    		•  1.87534424848905 bayes_pls_golite062009
  • beta-catenin binding
    		•  1.80347214616493 bayes_pls_golite062009
  • binding
    		•  1.71250041369331 bayes_pls_golite062009
  • enzyme activator activity
    		•  1.62073651679221 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.49796137854909 bayes_pls_golite062009
  • protein binding
    		•  1.34804002381061 bayes_pls_golite062009
  • armadillo repeat domain binding
    		•  0.461171601616737 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle