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View Structure Prediction Details

Protein: Axn-PA, Axn-PB
Organism: Drosophila melanogaster
Length: 745 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Axn-PA, Axn-PB.

Description E-value Query
Range
Subject
Range
Axn-PC, FBpp0306758 - The gene Axin is referred to in FlyBase by the symbol Dmel\Axn (CG7926, FBgn0026597). It is a protei...
596.0 [0..1] [745..1]

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Predicted Domain #1
Region A:
Residues: [1-184]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGHPSGIRK HDDNECSGPR PPVPGEESRV KKMTEGVADT SKNSSPSYLN WARTLNHLLE  60
   61 DRDGVELFKK YVEEEAPAYN DHLNFYFACE GLKQQTDPEK IKQIIGAIYR FLRKSQLSIS 120
  121 DDLRAQIKAI KTNPEIPLSP HIFDPMQRHV EVTIRDNIYP TFLCSEMYIL YIQQMSAQQE 180
  181 RCTS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.221849
Match: 1agrE
Description: Regulator of G-protein signalling 4, RGS4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase regulator activity 1.92987277493861 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.90800479999702 bayes_pls_golite062009
GTPase activator activity 1.87534424848905 bayes_pls_golite062009
beta-catenin binding 1.80347214616493 bayes_pls_golite062009
binding 1.71250041369331 bayes_pls_golite062009
enzyme activator activity 1.62073651679221 bayes_pls_golite062009
enzyme regulator activity 1.49796137854909 bayes_pls_golite062009
protein binding 1.34804002381061 bayes_pls_golite062009
armadillo repeat domain binding 0.461171601616737 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [185-277]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGATGSGSAG SSGSGGSSLA GACALPPTTA SGKQQLPQLV PPGAFINLPV SSVSGPPAGT  60
   61 CSASGSVYGP STSASSSGSI SATDTLPRSS TLP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [278-468]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLHEDSVLSL CDDFEKVQMQ EGGGSLGSGS VGAGARAPDY PIRLTRDLLI ATQKRRLEIR  60
   61 PPGAHGYVYN PSTTNTSYVP NSRVDSERAS VSSGGRTDSD TMSISSCSMD GRPYIQRRHS 120
  121 STESKAIRQS AMANKETNTF QVIPRTQRLH SNEHRPLKEE ELVSLLIPKL EEVKRKRDLE 180
  181 ERARERNPGA A

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [469-664]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLTNERSSAS DRAFAEAIRE KFALDEDNDQ DILDQHVSRV WKDQTPHRSP GTMSPCPPIP  60
   61 SRRRTATHDS GMVSDGAMSL SGHSMKHSKS MPDHSSCSRK LTNKWPSMNT DSGISMFSAD 120
  121 TVTKYKDASS RSGSSTASKL EEAKRRLEDE PRRSRRYAQP PMQHLSQQPL ASFSSSSSGG 180
  181 SISLPHQPPP LPAKPP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [665-745]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETIVVFSFCE EPVPYRIKIP GTQPTLRQFK DYLPRRGHFR FFFKTHCEDP DSPVIQEEIV  60
   61 NDSDILPLFG DKAMGLVKPS D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.221849
Match: 1wspA
Description: Crystal structure of axin dix domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle