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View Structure Prediction Details

Protein: Axn-PA, Axn-PB
Organism: Drosophila melanogaster
Length: 745 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Axn-PA, Axn-PB.

Description E-value Query
Range
Subject
Range
Axn-PC, FBpp0306758 - The gene Axin is referred to in FlyBase by the symbol Dmel\Axn (CG7926, FBgn0026597). It is a protei...
596.0 [0..1] [745..1]

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Predicted Domain #1
Region A:
Residues: [1-184]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGHPSGIRK HDDNECSGPR PPVPGEESRV KKMTEGVADT SKNSSPSYLN WARTLNHLLE  60
   61 DRDGVELFKK YVEEEAPAYN DHLNFYFACE GLKQQTDPEK IKQIIGAIYR FLRKSQLSIS 120
  121 DDLRAQIKAI KTNPEIPLSP HIFDPMQRHV EVTIRDNIYP TFLCSEMYIL YIQQMSAQQE 180
  181 RCTS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.221849
Match: 1agrE
Description: Regulator of G-protein signalling 4, RGS4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase regulator activity 1.92987277493861 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.90800479999702 bayes_pls_golite062009
GTPase activator activity 1.87534424848905 bayes_pls_golite062009
beta-catenin binding 1.80347214616493 bayes_pls_golite062009
binding 1.71250041369331 bayes_pls_golite062009
enzyme activator activity 1.62073651679221 bayes_pls_golite062009
enzyme regulator activity 1.49796137854909 bayes_pls_golite062009
protein binding 1.34804002381061 bayes_pls_golite062009
armadillo repeat domain binding 0.461171601616737 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [185-277]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGATGSGSAG SSGSGGSSLA GACALPPTTA SGKQQLPQLV PPGAFINLPV SSVSGPPAGT  60
   61 CSASGSVYGP STSASSSGSI SATDTLPRSS TLP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [278-468]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLHEDSVLSL CDDFEKVQMQ EGGGSLGSGS VGAGARAPDY PIRLTRDLLI ATQKRRLEIR  60
   61 PPGAHGYVYN PSTTNTSYVP NSRVDSERAS VSSGGRTDSD TMSISSCSMD GRPYIQRRHS 120
  121 STESKAIRQS AMANKETNTF QVIPRTQRLH SNEHRPLKEE ELVSLLIPKL EEVKRKRDLE 180
  181 ERARERNPGA A

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [469-664]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLTNERSSAS DRAFAEAIRE KFALDEDNDQ DILDQHVSRV WKDQTPHRSP GTMSPCPPIP  60
   61 SRRRTATHDS GMVSDGAMSL SGHSMKHSKS MPDHSSCSRK LTNKWPSMNT DSGISMFSAD 120
  121 TVTKYKDASS RSGSSTASKL EEAKRRLEDE PRRSRRYAQP PMQHLSQQPL ASFSSSSSGG 180
  181 SISLPHQPPP LPAKPP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [665-745]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETIVVFSFCE EPVPYRIKIP GTQPTLRQFK DYLPRRGHFR FFFKTHCEDP DSPVIQEEIV  60
   61 NDSDILPLFG DKAMGLVKPS D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.221849
Match: 1wspA
Description: Crystal structure of axin dix domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle