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Protein Overview: CG6255-PA

General Information:
Name(s) found: CG6255-PA / FBpp0083183 [FlyBase]
Description(s) found:
Found 35 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG6255 (CG6255, FBgn0038708). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:15287601..15288788. It has the cytological map location 92A5. Based on sequence similarity, it is predicted to have molecular function</span>: succinate-CoA ligase (GDP-forming) activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: metabolic process. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 342 amino acids

    Gene Ontology:
    Cellular Component: succinate-CoA ligase complex (GDP-forming) [ISS]
    Biological Process: metabolic process [IEA]
    Molecular Function: succinate-CoA ligase (GDP-forming) activity [ISS]
    ATP citrate synthase activity [IEA]
    binding [IEA]
    succinate-CoA ligase (ADP-forming) activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLNRGSKML LRALTPQILR RGKADYGKTV CNLKINKATK VLVQGFTGKQ ATFHSEESIK  60
   61 YGTNIVGGVN PKKGGTEHLG KPVFKSVAEA VEKAKPDATV IFIPPPSAAE GICAAIESEI 120
  121 GLIVAITEGI PQADMVRISQ MLNCQEKSRL LGPNCPGIIS PDQCKIGIMP GDIHKRGVVG 180
  181 IVSRSGTLTY ESVHQTTNVG LGQALCVGLG GDPFNGTSFI DALKVFLSDK EIKGIVMIGE 240
  241 IGGSAEEEAA DFLKEKNTGC EAKPVVGFIA GQTAPPGRRM GHAGAIISGG KGAAKDKVAA 300
  301 LEKAGVRMTA NPCHLGSTLL EEMIRLKLVP KPNKKKAQAG KK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..342] PSI-BLAST 85.69897 Succinyl-CoA synthetase, alpha-chain, N-terminal (CoA-binding) domain; Succinyl-CoA synthetase, alpha-chain, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • succinate-CoA ligase activity
    		•  11.5979130191209 bayes_pls_golite062009
  • succinate-CoA ligase (GDP-forming) activity
    		•  10.9659410855563 bayes_pls_golite062009
  • CoA-ligase activity
    		•  10.4192804448897 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  10.243481928473 bayes_pls_golite062009
  • ligase activity, forming carbon-sulfur bonds
    		•  9.48706872092269 bayes_pls_golite062009
  • succinate-CoA ligase (ADP-forming) activity
    		•  9.35325976720833 bayes_pls_golite062009
  • malate dehydrogenase activity
    		•  4.38786524125089 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  3.07329302783164 bayes_pls_golite062009
  • ligase activity
    		•  2.30626698552338 bayes_pls_golite062009
  • catalytic activity
    		•  1.90735517755117 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  1.70038641098437 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • malic enzyme activity
    		•  1.2147813077436 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.15639517822408 bayes_pls_golite062009
  • L-malate dehydrogenase activity
    		•  1.02646414923682 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.99118526697655 bayes_pls_golite062009
  • ATP citrate synthase activity
    		•  0.917482134347073 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.576163737662951 bayes_pls_golite062009
  • malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
    		•  0.120195861875768 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.0913823272876781 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.00644214957417527 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle