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Protein Overview: ken-PA

General Information:
Name(s) found: ken-PA / FBpp0072038 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • The gene ken and barbie is referred to in FlyBase by the symbol Dmel\ken (CG5575, FBgn0011236). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19757798..19764965. It has the cytological map location 60A6-60A7. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity; protein binding; nucleic acid binding. There is experimental evidence that it is involved in the biological process</span>: imaginal disc-derived female genitalia development; female analia development; male analia development; insemination; imaginal disc-derived male genitalia development; regulation of JAK-STAT cascade; phagocytosis, engulfment. 28 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; region of integument; adult; adult segment; antennal segment; embryonic/larval tracheal system; larval abdominal segment; female genitalia; spiracle; vulva; imaginal precursor; integumentary specialisation. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 601 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    Biological Process: phagocytosis, engulfment [IMP]
    male analia development [IMP]
    female analia development [IMP]
    copulation [NAS]
    regulation of JAK-STAT cascade [IMP]
    insemination [IMP]
    imaginal disc-derived male genitalia development [IMP]
    imaginal disc-derived female genitalia development [IMP]
    Molecular Function: nucleic acid binding [ISS]
    transcription factor activity [ISS]
    zinc ion binding [IEA]
    protein binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKEFQRMLML QYSKHGECIL KEIGAAFRGE HPADLTIVCE NKVKLHAHKL VLAAASPLIR  60
   61 NLLEDTHLSD CSTTVYFPDV NATYFKFLLD FLYSGQTCIT SRDVNYLHDL LLLLQIKSDS 120
  121 WKTTDSAYLS SKCGGLRDRA DRRKQQYTSP QNLEPDQTLK YEVDSVDESR NAADFSSAFN 180
  181 SNDNCESAAE CERSGGHNNK EEDEDDCTHK DNKSDKDTDE IVNLSNAPPS GTSGSNSNIS 240
  241 TSSNHQQQQH HHHHHHNHNN NNNNNNNNSS SSTINPVNLS LDLRTKSENS ASRTLGSGSD 300
  301 HSGIDLAVTA SESTKRKGLF FDSHKDVMKP LSDGSDINSS PENYVVTPHR KRRPGFHNTQ 360
  361 SDNQPFTSYP HSLLEELRLA KSTTSPISGF GSEKNMLAHL EDGALNGDTL TPDRKHLLEA 420
  421 QRNRAQSPEI PMHLGPQFVY QWQSNQNAAM SAMPNLQSRL SSLSHISLNL DHPEGRSGSA 480
  481 SGSGANLAGS NTHASSVREY RCEYCGKQFG MSWNLKTHLR VHTGEKPFAC RLCVAMFKQK 540
  541 AHLLKHLCSV HRNVITTTNG ADTENRYSCC FCSMCFESVQ ELVRHLSGHH NNLLLTKNLR 600
  601 E

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..124] PSI-BLAST 20.0 Crystal Structure of the B-Cell Lymphoma 6 (BCL6) BTB domain to 2.2 Angstrom
    2 View Details [125..245] FFAS03 1.11 No description for 2nysA was found.
    3 View Details [246..354] FFAS03 1.03 Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition
    4 View Details [355..601] PSI-BLAST 50.30103 No description for 2i13A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.03732153795237 bayes_pls_golite062009
  • DNA binding
    		•  3.50992893425527 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.39650042677839 bayes_pls_golite062009
  • transcription factor activity
    		•  2.77967244868934 bayes_pls_golite062009
  • binding
    		•  2.73171412378045 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.75044607782554 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.71028791830657 bayes_pls_golite062009
  • potassium channel activity
    		•  1.68568289502644 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  1.67964164378029 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.66275525611257 bayes_pls_golite062009
  • channel activity
    		•  1.66275525611257 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  1.66093274320162 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.65957499707356 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.65796419411359 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  1.65136812234746 bayes_pls_golite062009
  • cation channel activity
    		•  1.64020362040847 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  1.61906922892749 bayes_pls_golite062009
  • ion channel activity
    		•  1.61117213305435 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.60140834290891 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.59790228592718 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.54524970679069 bayes_pls_golite062009
  • gated channel activity
    		•  1.51274292313764 bayes_pls_golite062009
  • protein binding
    		•  1.38558174459188 bayes_pls_golite062009
  • transporter activity
    		•  0.55148533463451 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.44590765905907 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.278232864316812 bayes_pls_golite062009
  • catalytic activity
    		•  0.112500532859479 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.0258832038493364 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  2.42989701113001 bayes_pls_golite062009
  • transcription activator activity
    		•  0.394409337150498 bayes_pls_golite062009
  • catalytic activity
    		•  0.288440397080378 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle