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Any process that modulates the frequency, rate or extent of a signaling pathway. Any process that modulates the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. Any process that modulates the frequency or rate of activation of JAK protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it. Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway. Any process by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. Any process that stops, prevents or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity. A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: regulation of JAK-STAT cascade
Acc: GO:0046425
Aspect: Biological Process
Desc: Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway.
Proteins in PDR annotated with:
   This term: 24 [Search]
   Term or descendants: 99 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0046425 - regulation of JAK-STAT cascade (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle