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View Structure Prediction Details

Protein: ken-PA
Organism: Drosophila melanogaster
Length: 601 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ken-PA.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
614.0 [0..42] [593..2316]

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Predicted Domain #1
Region A:
Residues: [1-124]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKEFQRMLML QYSKHGECIL KEIGAAFRGE HPADLTIVCE NKVKLHAHKL VLAAASPLIR  60
   61 NLLEDTHLSD CSTTVYFPDV NATYFKFLLD FLYSGQTCIT SRDVNYLHDL LLLLQIKSDS 120
  121 WKTT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.0
Match: 1r28A
Description: Crystal Structure of the B-Cell Lymphoma 6 (BCL6) BTB domain to 2.2 Angstrom
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.03732153795237 bayes_pls_golite062009
DNA binding 3.50992893425527 bayes_pls_golite062009
nucleic acid binding 3.39650042677839 bayes_pls_golite062009
transcription factor activity 2.77967244868934 bayes_pls_golite062009
binding 2.73171412378045 bayes_pls_golite062009
substrate-specific transporter activity 1.75044607782554 bayes_pls_golite062009
transcription repressor activity 1.71028791830657 bayes_pls_golite062009
potassium channel activity 1.68568289502644 bayes_pls_golite062009
voltage-gated cation channel activity 1.67964164378029 bayes_pls_golite062009
passive transmembrane transporter activity 1.66275525611257 bayes_pls_golite062009
channel activity 1.66275525611257 bayes_pls_golite062009
voltage-gated ion channel activity 1.66093274320162 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.65957499707356 bayes_pls_golite062009
substrate-specific channel activity 1.65796419411359 bayes_pls_golite062009
voltage-gated channel activity 1.65136812234746 bayes_pls_golite062009
cation channel activity 1.64020362040847 bayes_pls_golite062009
voltage-gated potassium channel activity 1.61906922892749 bayes_pls_golite062009
ion channel activity 1.61117213305435 bayes_pls_golite062009
ion transmembrane transporter activity 1.60140834290891 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.59790228592718 bayes_pls_golite062009
cation transmembrane transporter activity 1.54524970679069 bayes_pls_golite062009
gated channel activity 1.51274292313764 bayes_pls_golite062009
protein binding 1.38558174459188 bayes_pls_golite062009
transporter activity 0.55148533463451 bayes_pls_golite062009
transmembrane transporter activity 0.44590765905907 bayes_pls_golite062009
sequence-specific DNA binding 0.278232864316812 bayes_pls_golite062009
catalytic activity 0.112500532859479 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.0258832038493364 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [125-245]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSAYLSSKCG GLRDRADRRK QQYTSPQNLE PDQTLKYEVD SVDESRNAAD FSSAFNSNDN  60
   61 CESAAECERS GGHNNKEEDE DDCTHKDNKS DKDTDEIVNL SNAPPSGTSG SNSNISTSSN 120
  121 H

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.11
Match: 2nysA
Description: No description for 2nysA was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.42989701113001 bayes_pls_golite062009
transcription activator activity 0.394409337150498 bayes_pls_golite062009
catalytic activity 0.288440397080378 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [246-354]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQQHHHHHH HNHNNNNNNN NNNSSSSTIN PVNLSLDLRT KSENSASRTL GSGSDHSGID  60
   61 LAVTASESTK RKGLFFDSHK DVMKPLSDGS DINSSPENYV VTPHRKRRP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.03
Match: 1yx4A
Description: Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [355-601]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFHNTQSDNQ PFTSYPHSLL EELRLAKSTT SPISGFGSEK NMLAHLEDGA LNGDTLTPDR  60
   61 KHLLEAQRNR AQSPEIPMHL GPQFVYQWQS NQNAAMSAMP NLQSRLSSLS HISLNLDHPE 120
  121 GRSGSASGSG ANLAGSNTHA SSVREYRCEY CGKQFGMSWN LKTHLRVHTG EKPFACRLCV 180
  181 AMFKQKAHLL KHLCSVHRNV ITTTNGADTE NRYSCCFCSM CFESVQELVR HLSGHHNNLL 240
  241 LTKNLRE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.30103
Match: 2i13A
Description: No description for 2i13A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle