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Protein Overview: Dscam-PAD

General Information:
Name(s) found: Dscam-PAD / FBpp0110344 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2017 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    neuronal cell body [IDA]
    axon [IDA]
    Biological Process: mushroom body development [IMP]
    dendrite self-avoidance [IDA][IMP]
    phagocytosis [IMP]
    axon guidance [IGI][IMP][TAS]
    peripheral nervous system development [IMP]
    neuron development [IMP]
    central nervous system morphogenesis [IMP]
    axonal fasciculation [IMP]
    axon extension involved in axon guidance [IMP]
    Molecular Function: protein binding [IDA]
    protein homodimerization activity [IPI]
    axon guidance receptor activity [IMP][NAS]
    bacterial cell surface binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVNQF YGADILMEYV IRGNAAVLKC SIPSFVADFV RVESWIDEEG 180
  181 TELRPSENYD GKYLVLPSGE LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE 240
  241 PVGSVAPKIS VENRLKNAEA RIGSTFTLFC PGQAYPVPFF RWYKFIEGTT RKQAVVLNDR 300
  301 VKQVSGTLII KDAVVEDSGK YLCVVNNSVG GESVETVLTV TAPLSAKIDP PTQTVDFGRP 360
  361 AVFTCQYTGN PIKTVSWMKD GKAIGHSEPV LRIESVKKED KGMYQCFVRN DQESAEASAE 420
  421 LKLGGRFDPP VIRQAFQEET MEPGPSVFLK CVAGGNPTPE ISWELDGKKI ANNDRYQVGQ 480
  481 YVTVNGDVVS YLNITSVHAN DGGLYKCIAK SKVGVAEHSA KLNVYGLPYI RQMEKKAIVA 540
  541 GETLIVTCPV AGYPIDSIVW ERDNRALPIN RKQKVFPNGT LIIENVERNS DQATYTCVAK 600
  601 NQEGYSARGS LEVQVMVAPK IAPFDFGDEP SNFGESASVQ CLVTSGDFPV SFAWLFNGRE 660
  661 INENVYDVSM VKLGKKISAL SIDIVRDHHA GNYTCVAVNR ATSVNFTAEL VVNVPPRWIL 720
  721 EPTDKAFAQG SDAKVECKAD GFPKPQVTWK KAVGDTPGEY KDLKKSDNIR VEEGTLHVDN 780
  781 IQKTNEGYYL CEAINGIGSG LSAVIMISVQ APPEFTEKLR NQTARRGEPA VLQCEAKGEK 840
  841 PIGILWNMNN MRLDPKNDNR YTIREEILST GVMSSLSIKR TERSDSALFT CVATNAFGSD 900
  901 DASINMIVQE VPEMPYALKV LDKSGRSVQL SWAQPYDGNS PLDRYIIEFK RSRASWSEID 960
  961 RVIVPGHTTE AQVQKLSPAT TYNIRIVAEN AIGTSQSSEA VTIITAEEAP SGKPQNIKVE1020
 1021 PVNQTTMRVT WKPPPRTEWN GEILGYYVGY KLSNTNSSYV FETINFITEE GKEHNLELQN1080
 1081 LRVYTQYSVV IQAFNKIGAG PLSEEEKQFT AEGTPSQPPS DTACTTLTSQ TIRVGWVSPP1140
 1141 LESANGVIKT YKVVYAPSDE WYDETKRHYK KTASSDTVLH GLKKYTNYTM QVLATTAGGD1200
 1201 GVRSVPIHCQ TEPDVPEAPT DVKALVMGNA AILVSWRPPA QPNGIITQYT VYSKAEGAET1260
 1261 ETKTQKVPHY QMSFEATELE KNKPYEFWVT ASTTIGEGQQ SKSIVAMPSD QVPAKIASFD1320
 1321 DTFTATFKED AKMPCLAVGA PQPEITWKIK GVEFSANDRM RVLPDGSLLI KSVNRQDAGD1380
 1381 YSCHAENSIA KDSITHKLIV LAPPQSPHVT LSATTTDALT VKLKPHEGDT APLHGYTLHY1440
 1441 KPEFGEWETS EVSVDSQKHN IEGLLCGSRY QVYATGFNNI GAGEASDILN TRTKGQKPKL1500
 1501 PEKPRFIEVS SNSVSLHFKA WKDGGCPMSH FVVESKKRDQ IEWNQISNNV KPDNNYVVLD1560
 1561 LEPATWYNLR ITAHNSAGFT VAEYDFATLT VTGGTIAPSR DLPELSAEDT IRIILSNLNL1620
 1621 VVPVVAALLV IIIAIIVICI LRSKGNHHKD DVVYNQTMGP GATLDKRRPD LRDELGYIAP1680
 1681 PNRKLPPVPG SNYNTCDRIK RGRGGLRSNH STWDPRRNPN LYEELKAPPV PMHGNHYGHA1740
 1741 HGNAECHYRH PGMEDEICPY ATFHLLGFRE EMDPTKAMNF QTFPHQNGHA GPVPGHAGTM1800
 1801 LPPGHPGHVH SRSGSQSMPR ANRYQRKNSQ GGQSSIYTPA PEYDDPANCA EEDQYRRYTR1860
 1861 VNSQGGSLYS GPGPEYDDPA NCAPEEDQYG SQYGGPYGQP YDHYGSRGSM GRRSIGSARN1920
 1921 PGNGSPEPPP PPPRNHDMSN SSFNDSKESN EISEAECDRD HGPRGNYGAV KRSPQPKDQR1980
 1981 TTEEMRKLIE RNETGPKQLQ LQQANGAGFT AYDTMAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..151] PSI-BLAST 78.09691 No description for 2v5sA was found.
    2 View Details [152..817] PSI-BLAST 55.69897 Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
    3 View Details [818..896] PSI-BLAST 37.154902 No description for 2nziA was found.
    4 View Details [897..1005] PSI-BLAST 10.39794 Solution Structure of The First Fibronectin Type III Domain of Human KIAA0343 protein
    5 View Details [1006..1115] PSI-BLAST 9.69897 No description for 2edxA was found.
    6 View Details [1116..1214] PSI-BLAST 13.39794 The solution structure of the third fibronectin type III domain of human Neogenin
    7 View Details [1215..1311] PSI-BLAST 8.39794 The fourth FN3 domain of human sidekick-2
    8 View Details [1312..1664] PSI-BLAST 22.69897 No description for 2v5yA was found.
    9 View Details [1665..1831] deduced N/A No confident structure predictions are available.
    10 View Details [1832..1938] MSA 2.132993 View MSA. No confident structure predictions are available.
    11 View Details [1939..2017] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • pattern binding
    		•  0.82756944920828 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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